Article (Scientific journals)
Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes
Llucià-Carol, Laia; Elena Muiño; Natalia Cullell et al.
2023In International Journal of Molecular Sciences, 24 (17)
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Keywords :
COVID-19; ischaemic stroke; GWAS; local genetic correlation; PRS
Abstract :
[en] We aimed to analyse whether patients with ischaemic stroke (IS) occurring within eight days after the onset of COVID-19 (IS-COV) are associated with a specific aetiology of IS. We used SUPERGNOVA to identify genome regions that correlate between the IS-COV cohort (73 IS-COV cases vs. 701 population controls) and different aetiological subtypes. Polygenic risk scores (PRSs) for each subtype were generated and tested in the IS-COV cohort using PRSice-2 and PLINK to find genetic associations. Both analyses used the IS-COV cohort and GWAS from MEGASTROKE (67,162 stroke patients vs. 454,450 population controls), GIGASTROKE (110,182 vs. 1,503,898), and the NINDS Stroke Genetics Network (16,851 vs. 32,473). Three genomic regions were associated (p-value < 0.05) with large artery atherosclerosis (LAA) and cardioembolic stroke (CES). We found four loci targeting the genes PITX2 (rs10033464, IS-COV beta = 0.04, p-value = 2.3 × 10−2, se = 0.02), previously associated with CES, HS6ST1 (rs4662630, IS-COV beta = −0.04, p-value = 1.3 × 10−3, se = 0.01), TMEM132E (rs12941838 IS-COV beta = 0.05, p-value = 3.6 × 10−4, se = 0.01), and RFFL (rs797989 IS-COV beta = 0.03, p-value = 1.0 × 10−2, se = 0.01). A statistically significant PRS was observed for LAA. Our results suggest that IS-COV cases are genetically similar to LAA and CES subtypes. Larger cohorts are needed to assess if the genetic factors in IS-COV cases are shared with the general population or specific to viral infection
Disciplines :
Genetics & genetic processes
Author, co-author :
Llucià-Carol, Laia
Elena Muiño
Natalia Cullell
Jara Cárcel-Márquez
Miquel Lledós
Cristina Gallego-Fabrega
Jesús Martin-Campos
Joan Martí-Fàbregas
Ana Aguilera-Simón
Anna M. Planas
Marta L. DeDiego
Alicia de Felipe Mimbrera
Jaime Masjuan
Sebastián García-Madrona
Tomás Segura
Esther González-Villar
Gemma Serrano-Heras
Ana Domínguez Mayoral
Paloma Menéndez-Valladares
Joan Montaner
Isabelle Migeotte
Rahmouni, Souad  ;  Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Darcis, Gilles ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne ; Université de Liège - ULiège > Département des sciences cliniques ; Université de Liège - ULiège > Département des sciences cliniques > GIGA-R : Immunopathologie - Maladies infectieuses et médecine interne générale
David Bernardo
Silvia Rojo
Eva C. Schulte
Ulrike Protzer
Lisa Fricke
Christof Winter
Mari E. K. Niemi
Mattia Cordioli
Pilar Delgado
Israel Fernández-Cadenas
More authors (23 more) Less
Language :
English
Title :
Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes
Publication date :
30 August 2023
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Special issue title :
Molecular and Genetic Aspects of SARS-CoV-2 Infection and COVID-19 Disease 2.0
Volume :
24
Issue :
17
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 September 2023

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