Article (Scientific journals)
Successful multimodal management of a large hepatocellular carcinoma in a non-cirrhotic liver: a case report.
Bihain, Clara; Delwaide, Jean; Meunier, Paul et al.
2023In Acta Chirurgica Belgica, p. 1 - 5
Peer reviewed
 

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Keywords :
Liver; cancer; embolization; outcome; surgery; transplantation; General Medicine
Abstract :
[en] [en] BACKGROUND: Hepatocellular carcinoma (HCC) found in a non cirrhotic liver represents a minority of HCC cases and remains poorly studied. Due to its specific characteristics and evolution, this tumour requires a different management compared to HCC in a cirrhotic liver. CASE REPORT: The authors describe the case of a 68-year-old man diagnosed with a large giant and only mildly symptomatic HCC in a non-cirrhotic liver. The 23 cm HCC was discovered when a thoracoabdominal computed tomography was performed following mild abdominal pain. After a multidisciplinary discussion the tumour was judged to be borderline, but potentially resectable after neoadjuvant therapy and preparation for surgery. The patient underwent selective internal radiation therapy radioembolization of the right hepatic artery lobe with 5,5 GBq of 90Y-labeled glass microspheres. It was followed by extended right hepatectomy after preparation by embolization of the right portal and the right hepatic veins. Thirty months after surgical resection the patient showed neither clinical, radiological nor biological signs of HCC recurrence. DISCUSSION: HCC in non-cirrhotic liver is less common than in cirrhotic liver but has a better prognosis, thanks to a greater opportunity for surgical resection. The symptoms often emerge late and are unspecific, thus delaying the HCC diagnosis. Advances in surgical resection by laparotomy or laparoscopy, and neoadjuvant therapy in preparation for surgery, have proven to be effective. However, high mortality persists due to late diagnosis linked to the inability of identifying groups at risk of HCC in the non-cirrhotic population and inadequate screening.
Disciplines :
Gastroenterology & hepatology
Surgery
Oncology
Author, co-author :
Bihain, Clara;  Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege (CHU ULiege), Liege, Belgium
Delwaide, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Meunier, Paul ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
GERARD, Laurent ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Jadoul, Alexandre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Language :
English
Title :
Successful multimodal management of a large hepatocellular carcinoma in a non-cirrhotic liver: a case report.
Publication date :
23 July 2023
Journal title :
Acta Chirurgica Belgica
ISSN :
0001-5458
Publisher :
Informa UK Limited, England
Pages :
1 - 5
Peer reviewed :
Peer reviewed
Available on ORBi :
since 24 August 2023

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