Article (Scientific journals)
An integrated measure of GABA to characterize post-stroke plasticity.
Paparella, Ilenia; Vandewalle, Gilles; Stagg, Charlotte J et al.
2023In NeuroImage: Clinical, 39, p. 103463
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Keywords :
EEG; GABA; MRS; Stroke recovery; TMS; Cognitive Neuroscience; Neurology (clinical); Neurology; Radiology, Nuclear Medicine and imaging
Abstract :
[en] Stroke is a major cause of death and chronic neurological disability. Despite the improvements in stroke care, the number of patients affected by stroke keeps increasing and many stroke survivors are left permanently disabled. Current therapies are limited in efficacy. Understanding the neurobiological mechanisms underlying post-stroke recovery is therefore crucial to find new therapeutic options to address this medical burden. Long-lasting and widespread alterations of γ-aminobutyric acid (GABA) neurotransmission seem to play a key role in stroke recovery. In this review we first discuss a possible model of GABAergic modulation of post-stroke plasticity. We then overview the techniques currently available to non-invasively assess GABA in patients and the conclusions drawn from this limited body of work. Finally, we address the remaining open questions to clarify GABAergic changes underlying post-stroke recovery, we briefly review possible ways to modulate GABA post stroke and propose a novel approach to thoroughly quantify GABA in stroke patients, by integrating its concentration, the activity of its receptors and its link with microstructural changes.
Disciplines :
Neurology
Author, co-author :
Paparella, Ilenia  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Vandewalle, Gilles  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Stagg, Charlotte J;  Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Medical Research Council Brain Network Dynamics Unit, Oxford, UK
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Language :
English
Title :
An integrated measure of GABA to characterize post-stroke plasticity.
Publication date :
03 July 2023
Journal title :
NeuroImage: Clinical
eISSN :
2213-1582
Publisher :
Elsevier BV, Netherlands
Volume :
39
Pages :
103463
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 August 2023

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