Drug Discovery; Pharmaceutical Science; Molecular Medicine
Abstract :
[en] [18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit the starting activity. The automation of the previously reported protocol for [18F]PARPi synthesis is challenging, as it requires transferring microvolumes of reagents, which many platforms cannot accommodate. We report a revised, high yield, and automated protocol for the radiosynthesis of [18F]PARPi, with final doses of over 20 GBq.
Warnier, Corentin ; Trasis, Rue Gilles Magnee 90, 4430 Ans, Belgium
Gendron, Thibault ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique-nucléaire ; Trasis, Rue Gilles Magnee 90, 4430 Ans, Belgium
Otabashi, Muhammad; Trasis, Rue Gilles Magnee 90, 4430 Ans, Belgium
Vriamont, Charles; Trasis, Rue Gilles Magnee 90, 4430 Ans, Belgium
Jackson, Alex ; Theragnostics Ltd., 1 Sans Walk, London EC1R 0LT, UK
Fendler, Wolfgang P; Klinik für Nuklearmedizin, Universitätsklinikum Essen (AöR), Hufelandstraße 55, D-45147 Essen, Germany
