Gendron Thibault

Département de chimie (sciences) > Chimie organique-nucléaire

GIGA Platforms - In Vivo Imaging

See author's contact details
ORCID
0000-0002-2162-3704
Main Referenced Co-authors
Sander, Kerstin (19)
Årstad, Erik (13)
Cybulska, Klaudia (8)
Davioud-Charvet, Elisabeth (8)
Arstad, Erik (7)
Main Referenced Keywords
Organic Chemistry (8); Positron-Emission Tomography (8); Drug Discovery (6); Fluorine Radioisotopes (5); Molecular Medicine (5);
Main Referenced Unit & Research Centers
FARAH. Médecine vétérinaire comparée - ULiège (3)
Department of Chemistry, University College London (2)
European School of Chemistry, Polymers and Materials, Bioorganic and Medicinal Chemistry, UMR CNRS 7509 (2)
Institute of Nuclear Medicine, University College London (2)
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège (1)
Main Referenced Disciplines
Chemistry (34)
Radiology, nuclear medicine & imaging (13)
Veterinary medicine & animal health (4)
Immunology & infectious disease (2)
Cardiovascular & respiratory systems (1)

Publications (total 39)

The most downloaded
226 downloads
Sander, K., Gendron, T., Cybulska, K. A., Sirindil, F., Zhou, J., Kalber, T. L., Lythgoe, M. F., Kurzawinski, T. R., Brown, M. J., Williams, B., & Årstad, E. (08 July 2021). Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism. Journal of Medicinal Chemistry, 64 (13), 9321 - 9329. doi:10.1021/acs.jmedchem.1c00539 https://hdl.handle.net/2268/296923

The most cited

185 citations (OpenAlex)

Sander, K., Lashley, T., Gami, P., Gendron, T., Lythgoe, M. F., Rohrer, J. D., Schott, J. M., Revesz, T., Fox, N. C., & Årstad, E. (November 2016). Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 12 (11), 1116 - 1124. doi:10.1016/j.jalz.2016.01.003 https://hdl.handle.net/2268/304411

Rizzoli, E., Bahri, M. A., Dammicco, S., Degueldre, C., Tutunaru, A.-C., Garigliany, M.-M., Gérardy, M., Bolen, G., Withofs, N., Gendron, T., & Clercx, C. (15 January 2026). Evaluation of [18F]FAPI-74 PET/CT in healthy dogs and in West Highland white terriers with canine idiopathic pulmonary fibrosis: a pilot study. Veterinary Journal, 315, 106565. doi:10.1016/j.tvjl.2026.106565
Peer Reviewed verified by ORBi

Storms, W., Celen, S., Maes, J., Serdons, K., Goffin, K., De Groot, T., Trump, L., Warnier, C., Gendron, T., Gérardy, R., Van Laere, K., Deroose, C. M., Kleynhans, J., & Cleeren, F. (14 December 2025). cGMP-compliant high-yield automated production of [18F]AlF-FAPI-74: optimization of quality control and evaluation of molar dose impact. EJNMMI Radiopharmacy and Chemistry, 11 (1), 3. doi:10.1186/s41181-025-00411-1
Peer Reviewed verified by ORBi

Kribii, R., Lê, D., Dammicco, S., & Gendron, T. (04 December 2025). Synthesis of Radiotracers to Image Neuroinflammation in Alzheimer’s Disease [Poster presentation]. Merck Organic Chemistry Symposium 2025, Blankenberge, Belgium.

Farooq, R., Gendron, T., Edwards, R. S., & Witney, T. H. (17 January 2025). Compact and cGMP-compliant automated synthesis of [18F]FSPG on the Trasis AllinOne™. EJNMMI Radiopharmacy and Chemistry, 10 (1), 2. doi:10.1186/s41181-024-00322-7
Peer Reviewed verified by ORBi

Rizzoli, E., Bahri, M. A., Dammicco, S., Degueldre, C., Legrand, M., Tutunaru, A.-C., Bolen, G., Withofs, N., Gendron, T., & Clercx, C. (19 December 2024). [18F]FAPI-74 PET/CT in dogs with idiopathic pulmonary fibrosis [Paper presentation]. 11th FARAH Day, Liège, Belgium.
Peer reviewed

Rizzoli, E., Bahri, M. A., Dammicco, S., Degueldre, C., Tutunaru, A.-C., Legrand, M., Bolen, G., Withofs, N., Gendron, T., & Clercx, C. (19 November 2024). [18F]FAPI-74 PET/CT in dogs with idiopathic pulmonary fibrosis [Paper presentation]. Veterinary Comparative Respiratory Society Symposium, Levi, Finland.
Peer reviewed

Rizzoli, E., Bahri, M. A., Dammicco, S., Degueldre, C., Legrand, M., Tutunaru, A.-C., Bolen, G., Withofs, N., Gendron, T., & Clercx, C. (12 October 2024). [18F]FAPI-74 PET/CT in dogs with idiopathic pulmonary fibrosis [Poster presentation]. 22nd International Colloquium on Lung and Airway Fibrosis, Athènes, Greece.
Peer reviewed

Gendron, T., Lanfranchi, D. A., Wenzel, N. I., Kessedjian, H., Jannack, B., Maes, L., Cojean, S., Müller, T. J. J., Loiseau, P. M., & Davioud-Charvet, E. (04 April 2024). Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones. Molecules, 29 (7), 1620. doi:10.3390/molecules29071620
Peer Reviewed verified by ORBi

Paty, L.-P., Degueldre, S., Provost, C., Schmitt, C., Trump, L., Fouque, J., Vriamont, C., Valla, F., Gendron, T., & Madar, O. (2024). Development of a versatile [68Ga]Ga-FAPI-46 automated synthesis suitable to multi-elutions of germanium-68/gallium-68 generators. Frontiers in Chemistry, 12, 1411312. doi:10.3389/fchem.2024.1411312
Peer Reviewed verified by ORBi

Pacelli, A., Zarrad, F., Warnier, C., Gendron, T., Otabashi, M., Vriamont, C., Jackson, A., Fendler, W. P., Herrmann, K., & Nader, M. (19 July 2023). Fully Automated, High-Dose Radiosynthesis of [18F]PARPi. Pharmaceuticals, 16 (7), 1024. doi:10.3390/ph16071024
Peer reviewed

Gendron, T., Destro, G., Straathof, N. J. W., Sap, J. B. I., Guibbal, F., Vriamont, C., Caygill, C., Atack, J. R., Watkins, A. J., Marshall, C., Hueting, R., Warnier, C., Gouverneur, V., & Tredwell, M. (20 March 2022). Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination. EJNMMI Radiopharmacy and Chemistry, 7 (1), 5. doi:10.1186/s41181-022-00158-z
Peer Reviewed verified by ORBi

Galovic, M., Erlandsson, K., Fryer, T. D., Hong, Y. T., Manavaki, R., Sari, H., Chetcuti, S., Thomas, B. A., Fisher, M., Sephton, S., Canales, R., Russell, J. J., Sander, K., Årstad, E., Aigbirhio, F. I., Groves, A. M., Duncan, J. S., Thielemans, K., Hutton, B. F., ... Gendron, T. (15 August 2021). Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain. NeuroImage, 237, 118194. doi:10.1016/j.neuroimage.2021.118194
Peer Reviewed verified by ORBi

Sander, K., Gendron, T., Cybulska, K. A., Sirindil, F., Zhou, J., Kalber, T. L., Lythgoe, M. F., Kurzawinski, T. R., Brown, M. J., Williams, B., & Årstad, E. (08 July 2021). Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism. Journal of Medicinal Chemistry, 64 (13), 9321 - 9329. doi:10.1021/acs.jmedchem.1c00539
Peer Reviewed verified by ORBi

Gendron, T., Pereira, R., Abdi, H. Y., Witney, T. H., & Årstad, E. (03 January 2020). Iron(II)/Persulfate Mediated Newman-Kwart Rearrangement. Organic Letters, 22 (1), 274 - 278. doi:10.1021/acs.orglett.9b04280
Peer Reviewed verified by ORBi

Glaser, M., Rajkumar, V., Diocou, S., Gendron, T., Yan, R., Sin, P. K. B., Sander, K., Carroll, L., Pedley, R. B., Aboagye, E. O., Witney, T. H., & Årstad, E. (17 December 2019). One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer. Scientific Reports, 9 (1), 19299. doi:10.1038/s41598-019-55992-0
Peer Reviewed verified by ORBi

Bascuñana, P.* , Gendron, T.* , Sander, K., Jahreis, I., Polyak, A., Ross, T. L., Bankstahl, M., Arstad, E., & Bankstahl, J. P. (November 2019). Ex vivo characterization of neuroinflammatory and neuroreceptor changes during epileptogenesis using candidate positron emission tomography biomarkers. Epilepsia, 60 (11), 2325 - 2333. doi:10.1111/epi.16353
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Gendron, T., Sander, K., Cybulska, K., Benhamou, L., Sin, P. K. B., Khan, A., Wood, M., Porter, M. J., & Årstad, E. (14 June 2019). Dibenzothiophene sulfonium salts as novel leaving groups for aromatic 18F-fluorination [Paper presentation]. Royal Society of Chemistry Radiochemistry Group Young Researchers Meeting, London, United Kingdom.
Peer reviewed

Greenwood, H. E., McCormick, P. N., Gendron, T., Glaser, M., Pereira, R., Maddocks, O. D. K., Sander, K., Zhang, T., Koglin, N., Lythgoe, M. F., Årstad, E., Hochhauser, D., & Witney, T. H. (15 April 2019). Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography. Clinical Cancer Research, 25 (8), 2471 - 2482. doi:10.1158/1078-0432.CCR-18-3423
Peer Reviewed verified by ORBi

McCormick, P. N., Greenwood, H. E., Glaser, M., Maddocks, O. D. K., Gendron, T., Sander, K., Gowrishankar, G., Hoehne, A., Zhang, T., Shuhendler, A. J., Lewis, D. Y., Berndt, M., Koglin, N., Lythgoe, M. F., Gambhir, S. S., Årstad, E., & Witney, T. H. (15 February 2019). Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc - Activity. Cancer Research, 79 (4), 853 - 863. doi:10.1158/0008-5472.CAN-18-2634
Peer Reviewed verified by ORBi

Pereira, R., Gendron, T., Sanghera, C., Greenwood, H. E., Newcombe, J., McCormick, P. N., Sander, K., Topf, M., Årstad, E., & Witney, T. H. (11 February 2019). Mapping Aldehyde Dehydrogenase 1A1 Activity using an [18F]Substrate-Based Approach. Chemistry, 25 (9), 2345 - 2351. doi:10.1002/chem.201805473
Peer Reviewed verified by ORBi

Gendron, T., Sander, K., Cybulska, K., Benhamou, L., Sin, P. K. B., Khan, A., Wood, M., Porter, M. J., & Årstad, E. (12 November 2018). Dibenzothiophene sulfonium salts as novel leaving groups for aromatic 18F-fluorination [Paper presentation]. Preclinical Nuclear Imaging Symposium (PNI), London, United Kingdom.
Peer reviewed

Gendron, T., Sander, K., Cybulska, K., Benhamou, L., Sin, P., Khan, A., Wood, M., Porter, M., & Årstad, E. (August 2018). Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18F-Fluorination. Journal of the American Chemical Society, 140 (35), 11125–11132. doi:10.1021/jacs.8b06730
Peer Reviewed verified by ORBi

Glaser, M., Gendron, T., McCormick, P., Berndt, M., Koglin, N., Sander, K., Witney, T., & Arstad, E. (14 May 2017). Automated Radiosynthesis and Biological Evaluation of [18F]FSPG. Journal of Labelled Compounds and Radiopharmaceuticals, 60, 7-110. doi:10.1002/jlcr.3507
Peer Reviewed verified by ORBi

Ellen Forty, Ilan Azuelos, Tammy Kalber, Gendron, T., May Zaw-Thin, Giovanni Vitulli, John Barrett, Dimitrios Anastasiou, Paul Mercer, Andy Blanchard, & Rachel Chambers. (2017). LSC - 2017 - Targeting glucose metabolism in experimental lung injury and fibrosis. European Respiratory Journal, 50 (suppl 61), 3470. doi:10.1183/1393003.congress-2017.PA3470
Peer Reviewed verified by ORBi

Sander, K., Lashley, T., Gami, P., Gendron, T., Lythgoe, M. F., Rohrer, J. D., Schott, J. M., Revesz, T., Fox, N. C., & Årstad, E. (November 2016). Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias. Alzheimer's and Dementia: the Journal of the Alzheimer's Association, 12 (11), 1116 - 1124. doi:10.1016/j.jalz.2016.01.003
Peer Reviewed verified by ORBi

Gendron, T., Sander, K., & Arstad, E. (26 October 2016). Tracer Development for MAO-B Imaging of Epileptogenesis – An Update [Paper presentation]. EPITARGET General Assembly Meeting, Marseilles, France.

Viira, B., Gendron, T., Lanfranchi, D. A., Cojean, S., Horvath, D., Marcou, G., Varnek, A., Maes, L., Maran, U., Loiseau, P. M., & Davioud-Charvet, E. (29 June 2016). In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids. Molecules, 21 (7), 853. doi:10.3390/molecules21070853
Peer reviewed

Gendron, T., Sander, K., Cybulska, K., Glaser, M., & Arstad, E. (23 September 2015). Development of Radiolabeled Tracers for Imaging of Epileptogenesis [Paper presentation]. EPITARGET General Assembly Meeting, Milano, Italy.

Gendron, T., Sander, K., Cybulska, K., Gray, V., & Arstad, E. (02 September 2015). Ring-closing synthesis of dibenzothiophene sulfonium salts and their use as precursors for aromatic [18F]fluorination – Application to direct labeling of the mGluR5 PET tracer [18F]FPEB [Paper presentation]. World Molecular Imaging Congress 2015, Honolulu, United States.
Peer reviewed

Sander, K., Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T. L., Badar, A., Robson, M., Johnson, S. P., Bauer, F., Mairinger, S., Stanek, J., Wanek, T., Kuntner, C., Kottke, T., Weizel, L., Dickens, D., Erlandsson, K., Hutton, B. F., ... Årstad, E. (13 August 2015). Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. Journal of Medicinal Chemistry, 58 (15), 6058 - 6080. doi:10.1021/acs.jmedchem.5b00652
Peer Reviewed verified by ORBi

Gendron, T., Sander, K., Cybulska, K., Gray, V., & Arstad, E. (21 May 2015). Dibenzothiophene sulfonium salts as leaving groups for aromatic [18F] fluorination-exemplified by highly efficient direct labeling of the mGluR5 PET tracer [18F] FPEB. Journal of Labelled Compounds and Radiopharmaceuticals, 58, 8-S8. doi:10.1002/jlcr.3302_1
Peer Reviewed verified by ORBi

Sander, K., Gendron, T., Yiannaki, E., Cybulska, K., Kalber, T. L., Lythgoe, M., & Arstad, E. (15 May 2015). Functionalized Triarylsulfonium Salts for Aromatic [18F] Fluorination of Drug-like Small Molecules. Journal of Labelled Compounds and Radiopharmaceuticals, 58, 4-S4.
Peer Reviewed verified by ORBi

Sander, K., Gendron, T., Yiannaki, E., Cybulska, K., Kalber, T., Lythgoe, M., & Årstad, E. (April 2015). Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18. Scientific Reports, 5 (1). doi:10.1038/srep09941
Peer Reviewed verified by ORBi

Gendron, T., Kessedjian, H., Davioud-Charvet, E., & Lanfranchi, D. A. (March 2015). Diastereoselective Synthesis of 2,6-Diaryltetrahydrothiopyran-4-ones by Phase-Transfer Catalysis. European Journal of Organic Chemistry, 2015 (8), 1790 - 1796. doi:10.1002/ejoc.201403516
Peer Reviewed verified by ORBi

Gendron, T., Lanfranchi, D. A., & Davioud-Charvet, E. (2013). Redox-Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase-based System to Fight Kinetoplastidal Parasites. In Trypanosomatid Diseases: Molecular Routes to Drug Discovery. Wiley-VCH. doi:10.1002/9783527670383.ch22
Editorial reviewed

Gendron, T., Lanfranchi, D. A., & Davioud-Charvet, E. (07 February 2013). Synthèse et évaluation de prodrogues de diarylidèneacétones à activité antiparasitaire [Paper presentation]. Young Research Fellow Meeting, Romainville, France.
Peer reviewed

Gendron, T., Davioud-Charvet, E., & Müller, T. J. J. (19 November 2012). Versatile synthesis of dissymmetric diarylideneacetones via a palladium-catalyzed coupling-isomerization reaction. Synthesis, 44 (24), 3829 - 3835. doi:10.1055/s-0032-1316811
Peer Reviewed verified by ORBi

Gendron, T., Lanfranchi, D. A., & Davioud-Charvet, E. (29 March 2012). Synthèse diastéréosélective de tetrahydrothiopyran-4-ones comme prodrogues de dibenzylidènes acétones à activité antiparasitaire [Paper presentation]. SCF Grand Est, Reims, France.
Peer reviewed

Gendron, T., Lanfranchi, D. A., & Davioud-Charvet, E. (22 November 2010). Discovery and optimization of a new palladium-catalyzed methodology for the synthesis of substituted dibenzylidenacetones [Paper presentation]. New Trends in Infectious Disease Research, Ellwangen, Germany.

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