[en] This chapter reviews the current state of knowledge about pharmacological treatments acting on the recovery of consciousness in patients with severe brain injury. Potential pharmacological agents (amantadine, apomorphine, levodopa, methylphenidate, bromocriptine, modafinil, selegiline, zolpidem, and baclofen) and their underlying mechanisms are examined. Clinical considerations, off-label use of specific medication, limitations of current research, and future directions are also outlined. Finally, we discuss the potential of whole-brain computational modelling to test treatments in-silico whilst also driving forward the understanding of the mechanisms of consciousness.
Disciplines :
Neurology
Author, co-author :
Szymkowicz, Emilie ✱; Université de Liège - ULiège > GIGA ; CHU Liège - Central University Hospital of Liege [BE] > Centre du Cerveau2
Alnagger, Naji ✱; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Central University Hospital of Liege [BE] > Centre du Cerveau2
Seyfzadehdarabad, Fatemeh ; Université de Liège - ULiège > GIGA ; CHU Liège - Central University Hospital of Liege [BE] > Centre du Cerveau2
Cardone, Paolo ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Central University Hospital of Liege [BE] > Centre du Cerveau2
Whyte, John; Moss Rehabilitation Research Institute and MossRehab,
Gosseries, Olivia ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Central University Hospital of Liege [BE] > Centre du Cerveau2
✱ These authors have contributed equally to this work.
Language :
English
Title :
Pharmacological treatments
Publication date :
2023
Main work title :
Coma and Disorders of Consciousness
Author, co-author :
Laureys, Steven ; Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau² ; Université de Liège - ULiège > GIGA > GIGA Consciousness
