Article (Scientific journals)
Structural and functional characterization of the locus coeruleus in young and late middle-aged individuals
Berger, Alexandre; Koshmanova, Ekaterina; Beckers, Elise et al.
2023In Frontiers in Neuroimaging, 2
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Abstract :
[en] IntroductionThe brainstem locus coeruleus (LC) influences a broad range of brain processes, including cognition. The so-called LC contrast is an accepted marker of the integrity of the LC that consists of a local hyperintensity on specific Magnetic Resonance Imaging (MRI) structural images. The small size of the LC has, however, rendered its functional characterization difficult in humans, including in aging. A full characterization of the structural and functional characteristics of the LC in healthy young and late middle-aged individuals is needed to determine the potential roles of the LC in different medical conditions. Here, we wanted to determine whether the activation of the LC in a mismatch negativity task changes in aging and whether the LC functional response was associated to the LC contrast.MethodsWe used Ultra-High Field (UHF) 7-Tesla functional MRI (fMRI) to record brain response during an auditory oddball task in 53 healthy volunteers, including 34 younger (age: 22.15y ± 3.27; 29 women) and 19 late middle-aged (age: 61.05y ± 5.3; 14 women) individuals.ResultsWhole-brain analyses confirmed brain responses in the typical cortical and subcortical regions previously associated with mismatch negativity. When focusing on the brainstem, we found a significant response in the rostral part of the LC probability mask generated based on individual LC images. Although bilateral, the activation was more extensive in the left LC. Individual LC activity was not significantly different between young and late middle-aged individuals. Importantly, while the LC contrast was higher in older individuals, the functional response of the LC was not significantly associated with its contrast.DiscussionThese findings may suggest that the age-related alterations of the LC structural integrity may not be related to changes in its functional response. The results further suggest that LC responses may remain stable in healthy individuals aged 20 to 70.
Research center :
CRC - Centre de Recherches du Cyclotron - ULiège [BE]
Disciplines :
Neurology
Author, co-author :
Berger, Alexandre
Koshmanova, Ekaterina ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Beckers, Elise  ;  Université de Liège - ULiège > GIGA
Sharifpour, Roya  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Paparella, Ilenia  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Campbell, Islay ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Mortazavi, Nasrin ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Balda Aizpurua, Fermin  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Yi, Yeo-Jin
Lamalle, Laurent ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Dricot, Laurence
Phillips, Christophe  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Jacobs, Heidi I. L.
Talwar, Puneet ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
El Tahry, Riëm
Sherif, Siya
Vandewalle, Gilles  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
More authors (7 more) Less
Language :
English
Title :
Structural and functional characterization of the locus coeruleus in young and late middle-aged individuals
Publication date :
21 June 2023
Journal title :
Frontiers in Neuroimaging
eISSN :
2813-1193
Publisher :
Frontiers Media SA
Volume :
2
Peer reviewed :
Peer reviewed
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FWB - Fédération Wallonie-Bruxelles [BE]
FRA - Fondation pour la Recherche sur la Maladie d'Alzheimer [FR]
Waalse Gewest [BE]
European Union. Marie Skłodowska-Curie Actions [BE]
WELBIO - Walloon Excellence in Life Sciences and Biotechnology [BE]
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since 12 July 2023

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