Evidence in peroneal nerve entrapment: A scoping review

[en] Background and purpose: Daily management of patients with foot drop due to peroneal nerve entrapment varies between a purely conservative treatment and early surgery, with no high-quality evidence to guide current practice. Electrodiagnostic (EDX) prognostic features and the value of imaging in establishing and supplementing the diagnosis have not been clearly established. Methods: We performed a literature search in the online databases MEDLINE, Embase, and the Cochrane Library. Of the 42 unique articles meeting the eligibility criteria, 10 discussed diagnostic performance of imaging, 11 reported EDX limits for abnormal values and/or the value of EDX in prognostication, and 26 focused on treatment outcome. Results: Studies report high sensitivity and specificity of both ultrasound (varying respectively from 47.1% to 91% and from 53% to 100%) and magnetic resonance imaging (MRI; varying respectively from 31% to 100% and from 73% to 100%). One comparative trial favoured ultrasound over MRI. Variable criteria for a conduction block (>20%–≥50) were reported. A motor conduction block and any baseline compound motor action potential response were identified as predictors of good outcome. Based predominantly on case series, the percentage of patients with good outcome ranged 0%–100% after conservative treatment and 40%−100% after neurolysis. No study compared both treatments. Conclusions: Ultrasound and MRI have good accuracy, and introducing imaging in the standard diagnostic workup should be considered. Further research should focus on the role of EDX in prognostication. No recommendation on the optimal treatment strategy of peroneal nerve entrapment can be made, warranting future randomized controlled trials. © 2021 European Academy of Neurology

Disciplines :

Surgery

Author, co-author :

Oosterbos, C.; Research Group Experimental Neurosurgery and Neuroanatomy and Leuven Brain Institute, Catholic University of Leuven, Leuven, Belgium, Department of Neurosurgery, University Hospitals of Leuven, Leuven, Belgium

Decramer, T.; Research Group Experimental Neurosurgery and Neuroanatomy and Leuven Brain Institute, Catholic University of Leuven, Leuven, Belgium, Department of Neurosurgery, University Hospitals of Leuven, Leuven, Belgium

Rummens, S.; Department of Physical Medicine and Rehabilitation, University Hospitals of Leuven, Leuven, Belgium, Locomotor and Neurological Disorders, Catholic University of Leuven, Leuven, Belgium

Weyns, F.; Department of Neurosurgery, East Limburg Hospital, Genk, Belgium, Neurosciences, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium

Dubuisson, Annie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurochirurgie

Ceuppens, J.; Department of Neurosurgery, Groeninge General Hospital, Kortrijk, Belgium

Schuind, S.; Department of Neurosurgery, Erasme Hospital, Brussels, Belgium

Groen, J.; Nerve Centre, University of Leiden, Leiden, Netherlands

van Loon, J.; Research Group Experimental Neurosurgery and Neuroanatomy and Leuven Brain Institute, Catholic University of Leuven, Leuven, Belgium, Department of Neurosurgery, University Hospitals of Leuven, Leuven, Belgium

Rasulic, L.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia, Clinic for Neurosurgery, University Clinical Centre of Serbia, Belgrade, Serbia

Lemmens, R.; Department of Neurosciences, Experimental Neurology, Catholic University of Leuven, Leuven, Belgium, Centre for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium, Department of Neurology, University Hospitals of Leuven, Leuven, Belgium

Theys, T.; Research Group Experimental Neurosurgery and Neuroanatomy and Leuven Brain Institute, Catholic University of Leuven, Leuven, Belgium, Department of Neurosurgery, University Hospitals of Leuven, Leuven, Belgium

Language :

English

Title :

Evidence in peroneal nerve entrapment: A scoping review

Publication date :

2022

Journal title :

European Journal of Neurology

ISSN :

1351-5101

eISSN :

1468-1331

Publisher :

John Wiley and Sons Inc

Volume :

Issue :

Pages :

665 - 679

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 June 2023

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