[en] The induction of thymic lymphomas by inoculation of the Radiation Leukemia Virus (RadLV) requires interactions between RadLV, lymphoid cells and thymus microenvironment. The possible localization of this interaction within the peculiar lymphoepithelial complexes called 'thymic nurse cells' (TNCs) has been investigated. Electron microscopic studies, as well as in vitro experiments using a very sensitive infectious centre detection assay demonstrated that most of the first virus producing cells after RadLV inoculation are located within the TNCs. Most of these structures belong to the thymus subcapsular zone. They contain lymphoid cells with the phenotype of the major (cortical) thymocyte population. Data support the view that a limited subpopulation of subcapsular immature thymocyte can act as specific targets for productive infection with RadLV. Furthermore, the initiation of virus replication appears related to the interaction between the immature thymocyte and the 'nurse cells' microenvironment.
Boniver (1981) Pathogenesis of thymic lymphomas in C57BL mice. Path. Res. Prac. 171:268.
Boniver, Simar, Courtoy, Betz (1978) Quantitative analysis of thymus lymphoid cells during murine radioleukemogenesis. Cancer Res. 38:52.
Boniver, Decleve, Finn, Honsik, Lieberman, Kaplan (1980) Detection of infectious centers in C57BL/Ka lymphoid cell populations infected in vitro by the radiation leukemia virus. Cancer Res. 40:544.
Boniver, Decleve, Dailey, Honsik, Lieberman, Kaplan (1981) Macrophage and lymphocyte depleted thymus reticuloepithelial cell cultures: establishment and functional influence on T-lymphocyte maturation. C-type virus expression and lymphomatous transformation in vitro , 3rd edn, Thymus; 2:193.
Boniver, Decleve, Honsik, Lieberman, Kaplan (1981) Phenotypic characterization of thymus target cells susceptible to productive infection by the radiation leukemia virus. J. natn. Cancer Inst. 67:1139.
Cantor, Weissman (1976) Development and function of subpopulations of thymocytes and T lymphocytes. Prog. Allergy 20:1.
Carnes, Lieberman, Marchildon, Kaplan (1968) Replication of type C virus particles in thymus grafts of C57BL mice inoculated with radiation leukemia virus. Cancer Res. 28:98.
Decleve, Sato, Lieberman, Kaplan (1974) Selective thymic localization of murine leukemia virus related antigen in C57BL-Ka mice after inoculation with radiation leukemia virus. Proc. natn. Acad. Sci. U.S.A. , 3rd edn; 71:3124.
Decleve, Travis, Weissman, Lieberman, Kaplan (1975) Focal infection and transformation ‘in situ’ of thymus cell subclasses by a thymotropic murine leukemia virus. Cancer Res. 35:3585.
Decleve, Lieberman, Kaplan (1977) In vivo interactions between RNA viruses isolated from the C57BL Ka strain of mice. Virology 81:270.
Decleve, Lieberman, Ihle, Rosenthal, Lung, Kaplan (1978) Physicochemical, biological and serological properties of a leukemogenic virus isolated from cultured RadLV induced lymphomas of C57BL Ka mice. Virology 90:23.
Herzenberg, Herzenberg (1978) Analysis and separation using the fluorescence-activated cell sorter (FACS). Handbook of Experimental Immunology, D.M. Weir, 3rd edn, Blackwell Scientific Publications, Oxford; .
Julius, Simpson, Herzenberg (1973) A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immun. 3:645.
Kaplan (1974) Leukemia and lymphoma in experimental and domestic animals. Ser. Haemat. 7:94.
Kaplan (1978) Review: Etiology of lymphomas and leukemias. Role of C type RNA viruses , Edn 5, Leukemia Res.; 2:253.
Kaplan, Lieberman (1976) The role of lymphoid and haematopoietic target cells in viral lymphomagenesis of C57BL/Ka mice. II. Neoplastic transformation of bone marrow derived cells in the thymic microenvironment. Blood Cells 2:301.
Kyewski, Hunsmann, Friedrich, Ketelsen, Wekerle (1981) Thymic nurse cells: intraepithelial thymocytes sojourn and its possible relevance for the pathogenesis of AKR lymphomas. Haematology and Blood Transfusion , Edn 5, Neth, Gallo, Graaf, Mannweiler, Winkler, Modern Trends in Human Leukemia IV, Springer, Berlin; 26:372.
Lieberman, Kaplan (1966) Lymphoid tumor induction by mouse thymocytes infected in vitro with radiation leukemia virus. Natn. Cancer Inst. Monogr. 22:549.
Lieberman, Kaplan (1976) The role of lymphoid and hematopoietic target cells in viral lymphomagenesis of C57BL Ka mice. I.—Susceptibility to viral replication. Blood Cells 2:291.
Lieberman, Decleve, Kaplan (1978) Rapid in vitro assay for thymotropic, leukemogenic murine C type RNA viruses. Virology 90:274.
Lieberman, Decleve, Finn, Ricciardi-Castagnoli, Boniver, Kaplan (1979) Establishment, characterization and virus expression of cell lines from virus-induced lymphomas of C57BL/Ka mice. Int. J. Cancer 24:168.
Loken, Herzenberg (1975) Analysis of cell populations with a fluorescent activated cell sorter. Ann. N.Y. Acad. Sci. 254:163.
Scollay, Jacobs, Jerabek, Butcher, Weissman (1980) T cell maturation: thymocyte and thymus migrant subpopulations defined with monoclonal antibodies to MHC region antigens. J. Immun. 124:2845.
Wekerli, Ketelsen (1980) Thymic nurse cells Ia-bearing epithelium involved in T lymphocyte differentiation. Nature 283:402.
Wekerle, Ketelsen, Ernst (1980) Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization , Edn 5, J. exp. Med.; 151:925.
Zinkernagel (1978) Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells H-2 restrictions. Specificity and H-2 linked Ir gene control , Edn 5, Immun. Rev.; 42:224.
