Article (Scientific journals)
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages.
Loos, Pauline; Baiwir, Jérôme; Maquet, Céline et al.
2023In Science Immunology, 8 (80), p. 9041
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Keywords :
Humans; Mice; Animals; Macrophages, Alveolar; Immunity, Innate; Lymphocytes; Epstein-Barr Virus Infections; Asthma; Immunology
Abstract :
[en] Immunological dysregulation in asthma is associated with changes in exposure to microorganisms early in life. Gammaherpesviruses (γHVs), such as Epstein-Barr virus, are widespread human viruses that establish lifelong infection and profoundly shape host immunity. Using murid herpesvirus 4 (MuHV-4), a mouse γHV, we show that after infection, lung-resident and recruited group 2 innate lymphoid cells (ILC2s) exhibit a reduced ability to expand and produce type 2 cytokines in response to house dust mites, thereby contributing to protection against asthma. In contrast, MuHV-4 infection triggers GM-CSF production by those lung ILC2s, which orders the differentiation of monocytes (Mos) into alveolar macrophages (AMs) without promoting their type 2 functions. In the context of γHV infection, ILC2s are therefore essential cells within the pulmonary niche that imprint the tissue-specific identity of Mo-derived AMs and shape their function well beyond the initial acute infection.
Disciplines :
Immunology & infectious disease
Author, co-author :
Loos, Pauline  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Baiwir, Jérôme  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Maquet, Céline  ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Javaux, Justine ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie vétérinaire
Sandor, Rémy ;  Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire
LALLEMAND, François  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiothérapie
Marichal, Thomas  ;  Université de Liège - ULiège > GIGA > GIGA I3 - Immunophysiology
Machiels, Bénédicte   ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
Gillet, Laurent   ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire
 These authors have contributed equally to this work.
Language :
English
Title :
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages.
Publication date :
24 February 2023
Journal title :
Science Immunology
eISSN :
2470-9468
Publisher :
American Association for the Advancement of Science (AAAS), United States
Volume :
8
Issue :
80
Pages :
eabl9041
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 May 2023

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