Article (Scientific journals)
Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men.
Deantoni, Michele; Baillet, Marion; Hammad, Grégory et al.
2023In NeuroImage, 272, p. 120045
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Keywords :
Myelin markers; Sleep homeostasis; Sleep slow-wave activity; semi-quantitative MRI; Cognitive Neuroscience; Neurology
Abstract :
[en] Sleep has been suggested to contribute to myelinogenesis and associated structural changes in the brain. As a principal hallmark of sleep, slow-wave activity (SWA) is homeostatically regulated but also differs between individuals. Besides its homeostatic function, SWA topography is suggested to reflect processes of brain maturation. Here, we assessed whether interindividual differences in sleep SWA and its homeostatic response to sleep manipulations are associated with in-vivo myelin estimates in a sample of healthy young men. Two hundred twenty-six participants (18-31 y.) underwent an in-lab protocol in which SWA was assessed at baseline (BAS), after sleep deprivation (high homeostatic sleep pressure, HSP) and after sleep saturation (low homeostatic sleep pressure, LSP). Early-night frontal SWA, the frontal-occipital SWA ratio, as well as the overnight exponential SWA decay were computed over sleep conditions. Semi-quantitative magnetization transfer saturation maps (MTsat), providing markers for myelin content, were acquired during a separate laboratory visit. Early-night frontal SWA was negatively associated with regional myelin estimates in the temporal portion of the inferior longitudinal fasciculus. By contrast, neither the responsiveness of SWA to sleep saturation or deprivation, its overnight dynamics, nor the frontal/occipital SWA ratio were associated with brain structural indices. Our results indicate that frontal SWA generation tracks inter-individual differences in continued structural brain re-organization during early adulthood. This stage of life is not only characterized by ongoing region-specific changes in myelin content, but also by a sharp decrease and a shift towards frontal predominance in SWA generation.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE]
Disciplines :
Neurology
Author, co-author :
Deantoni, Michele  ;  Université de Liège - ULiège > GIGA
Baillet, Marion  ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Hammad, Grégory   ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Berthomier, Christian;  Physip, Paris, France
Reyt, Mathilde ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Jaspar, Mathieu ;  Université de Liège - ULiège > Département de Psychologie
Meyer, Christelle;  GIGA-CRC in Vivo Imaging, University of Liège, Belgium
Van Egroo, Maxime;  Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands
Talwar, Puneet;  GIGA-CRC in Vivo Imaging, University of Liège, Belgium
Lambot, Eric;  GIGA-CRC in Vivo Imaging, University of Liège, Belgium
Chellappa, Sarah L;  Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany
Degueldre, Christian ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Luxen, André;  GIGA-CRC in Vivo Imaging, University of Liège, Belgium
Salmon, Eric ;  Université de Liège - ULiège > Département de physique > S.U.P.R.A.S.
Balteau, Evelyne;  GIGA-CRC in Vivo Imaging, University of Liège, Belgium
Phillips, Christophe  ;  Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore)
Dijk, Derk-Jan;  Sleep Research Centre, University of Surrey, Guildford, UK, UK Dementia Research Institute, Care Research & Technology Centre at Imperial College London and the University of Surrey, Guildford, UK
Vandewalle, Gilles  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Muto, Vincenzo ;  GIGA-CRC in Vivo Imaging, University of Liège, Belgium. Electronic address: vincenzo.muto@uliege.be
Schmidt, Christina   ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
More authors (12 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men.
Publication date :
29 March 2023
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Elsevier BV, United States
Volume :
272
Pages :
120045
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 April 2023

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