[en] Bioplastics, which are plastic materials produced from renewable bio-based feedstocks, have been investigated for their potential as an attractive alternative to petroleum-based plastics. Despite the harmful effects of plastic accumulation in the environment, bioplastic production is still underdeveloped. Recent advances in strain development, genome sequencing, and editing technologies have accelerated research efforts toward bioplastic production and helped to advance its goal of replacing conventional plastics. In this review, we highlight bioengineering approaches, new advancements, and related challenges in the bioproduction and biodegradation of plastics. We cover different types of polymers, including polylactic acid (PLA) and polyhydroxyalkanoates (PHAs and PHBs) produced by bacterial, microalgal, and plant species naturally as well as through genetic engineering. Moreover, we provide detailed information on pathways that produce PHAs and PHBs in bacteria. Lastly, we present the prospect of using large-scale genome engineering to enhance strains and develop microalgae as a sustainable production platform.
Disciplines :
Biotechnology
Author, co-author :
Al-Khairy, Dina; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Fu, Weiqi; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates ; Department of Marine Science, Ocean College, Zhejiang University & Donghai Laboratory, Zhoushan 316021, China
Alzahmi, Amnah Salem; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates ; Center for Genomics and Systems Biology (CGSB), Institute Abu Dhabi, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Twizere, Jean-Claude ; Université de Liège - ULiège > GIGA > GIGA Molecular Biology of Diseases - Viral Interactomes Network ; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Amin, Shady A ; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates ; Center for Genomics and Systems Biology (CGSB), Institute Abu Dhabi, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Salehi-Ashtiani, Kourosh ; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates ; Center for Genomics and Systems Biology (CGSB), Institute Abu Dhabi, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Mystikou, Alexandra ; Division of Science and Math, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates ; Center for Genomics and Systems Biology (CGSB), Institute Abu Dhabi, New York University Abu Dhabi, Abu Dhabi 129188, United Arab Emirates
Language :
English
Title :
Closing the Gap between Bio-Based and Petroleum-Based Plastic through Bioengineering.
NYU Abu Dhabi - New York University Abu Dhabi [AE] Zhejiang University [CN]
Funding text :
This research was funded by [Faculty Award AD060 from the Division of Science, NYU Abu Dhabi, to K.S.-A.], [NYU Abu Dhabi Research Institute Award under Tamkeen to the NYUAD Center for Genomics and Systems Biology, sub-award 73 71210 CGSB9], and [NYU Abu Dhabi Award AD179 to S.A.A.] W.F. was funded by [the Hundred Talents Programme of Zhejiang University and also supported by Science Foundation of Donghai Laboratory, grant no. DH-2022KF0203]. J.-C.T. is a Maitre de Recherche from the Fonds de la Recherche Scientifique (FRS-FNRS, Wallonia-Brussels Federation, Belgium).
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