Article (Scientific journals)
Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis.
Guiot, Julien; Henket, Monique; Remacle, Claire et al.
2023In Respiratory Research, 24 (1), p. 112
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Keywords :
COVID-19; Idiopathic pulmonary fibrosis; Post-COVID-19 lung fibrosis; microRNA
Abstract :
[en] [en] BACKGROUND: Pulmonary fibrosis is an emerging complication of SARS-CoV-2 infection. In this study, we speculate that patients with COVID-19 and idiopathic pulmonary fibrosis (IPF) may share aberrant expressed microRNAs (miRNAs) associated to the progression of lung fibrosis. OBJECTIVE: To identify miRNAs presenting similar alteration in COVID-19 and IPF, and describe their impact on fibrogenesis. METHODS: A systematic review of the literature published between 2010 and January 2022 (PROSPERO, CRD42022341016) was conducted using the key words (COVID-19 OR SARS-CoV-2) AND (microRNA OR miRNA) or (idiopathic pulmonary fibrosis OR IPF) AND (microRNA OR miRNA) in Title/Abstract. RESULTS: Of the 1988 references considered, 70 original articles were appropriate for data extraction: 27 studies focused on miRNAs in COVID-19, and 43 on miRNAs in IPF. 34 miRNAs were overlapping in COVID-19 and IPF, 7 miRNAs presenting an upregulation (miR-19a-3p, miR-200c-3p, miR-21-5p, miR-145-5p, miR-199a-5p, miR-23b and miR-424) and 9 miRNAs a downregulation (miR-17-5p, miR-20a-5p, miR-92a-3p, miR-141-3p, miR-16-5p, miR-142-5p, miR-486-5p, miR-708-3p and miR-150-5p). CONCLUSION: Several studies reported elevated levels of profibrotic miRNAs in COVID-19 context. In addition, the balance of antifibrotic miRNAs responsible of the modulation of fibrotic processes is impaired in COVID-19. This evidence suggests that the deregulation of fibrotic-related miRNAs participates in the development of fibrotic lesions in the lung of post-COVID-19 patients.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Henket, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Remacle, Claire ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Molecular Angiogenesis Laboratory
Cambier, Maureen  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Molecular Angiogenesis Laboratory
Struman, Ingrid  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Molecular Angiogenesis Laboratory
Winandy, Marie-Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Moermans, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Louis, Edouard  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Malaise, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Ribbens, Clio ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Njock, Makon-Sébastien  ;  Université de Liège - ULiège > GIGA > GIGA I3 - Pneumology
Language :
English
Title :
Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis.
Publication date :
15 April 2023
Journal title :
Respiratory Research
ISSN :
1465-9921
eISSN :
1465-993X
Publisher :
Springer Science and Business Media LLC, England
Volume :
24
Issue :
1
Pages :
112
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
CHU Liège - Centre Hospitalier Universitaire de Liège [BE]
Funding text :
Fonds d’Investissement de Recherche Scientifique du Centre Hospitalier Universitaire de Liège
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