Re-Evaluating the Relevance of the Oxygen-Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition

cell culture; OGD; cortex; mouse; Inorganic Chemistry; Organic Chemistry; Physical and Theoretical Chemistry; Computer Science Applications; Spectroscopy; Molecular Biology; General Medicine; Catalysis

Disciplines :

Neurology

Author, co-author :

D'Aes, Tine ; Université de Liège - ULiège > GIGA > GIGA Neurosciences ; Licensee MDPI, Basel, Switzerland

Marlier, Quentin ; Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-Research

Verteneuil, Sébastien ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Developmental Neurobiology ; Licensee MDPI, Basel, Switzerland

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > > Service dermatopathologie ; Licensee MDPI, Basel, Switzerland

Vandenbosch, Renaud ^✱; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Licensee MDPI, Basel, Switzerland

Malgrange, Brigitte ^✱; Université de Liège - ULiège > Département des sciences cliniques > Neurologie ; Licensee MDPI, Basel, Switzerland

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Re-Evaluating the Relevance of the Oxygen-Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition

Publication date :

10 April 2023

Journal title :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Publisher :

MDPI AG

Volume :

Issue :

Pages :

7009

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.mdpi.com/1422-0067/24/8/7009/pdf

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Leon Fredericq Foundation
UNESCO - Organisation des Nations unies pour l'Éducation, la Science et la Culture
L'Oréal

Funding text :

This research was funded by F.R.S.—FNRS, the Léon Fredericq Foundation, L’Oréal-UNESCO For Women in Science, and the Faculty of Medicine of the University of Liège. T.D. is a FNRS doctoral fellow and B.M. is a research director at the FRS-FNRS.

Available on ORBi :

since 12 April 2023

Statistics

Number of views

88 (14 by ULiège)

Number of downloads

55 (6 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Deb P. Sharma S. Hassan K.M. Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis Pathophysiology 2010 17 197 218 10.1016/j.pathophys.2009.12.001 20074922
Maida C.D. Norrito R.L. Daidone M. Tuttolomondo A. Pinto A. Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches Int. J. Mol. Sci. 2020 21 6454 10.3390/ijms21186454 32899616
Kroemer G. Galluzzi L. Vandenabeele P. Abrams J. Alnemri E.S. Baehrecke E.H. Blagosklonny M.V. El-Deiry W.S. Golstein P. Green D.R. et al. Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009 Cell Death Differ. 2009 16 3 11 10.1038/cdd.2008.150
Nikoletopoulou V. Markaki M. Palikaras K. Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy Biochim. Biophys. Acta 2013 1833 3448 3459 10.1016/j.bbamcr.2013.06.001
Tuo Q.Z. Zhang S.T. Lei P. Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications Med. Res. Rev. 2022 42 259 305 10.1002/med.21817 33957000
Fricker M. Tolkovsky A.M. Borutaite V. Coleman M. Brown G.C. Neuronal Cell Death Physiol. Rev. 2018 98 813 880 10.1152/physrev.00011.2017
Orrenius S. Zhivotovsky B. Nicotera P. Regulation of cell death: The calcium-apoptosis link Nat. Rev. Mol. Cell Biol. 2003 4 552 565 10.1038/nrm1150
Malumbres M. Cyclin-dependent kinases Genome Biol. 2014 15 122 10.1186/gb4184
Larochelle S. Pandur J. Fisher R.P. Salz H.K. Suter B. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity Genes Dev. 1998 12 370 381 10.1101/gad.12.3.370
Ganuza M. Saiz-Ladera C. Canamero M. Gomez G. Schneider R. Blasco M.A. Pisano D. Paramio J.M. Santamaria D. Barbacid M. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion EMBO J. 2012 31 2498 2510 10.1038/emboj.2012.94
Rashidian J. Iyirhiaro G.O. Park D.S. Cell cycle machinery and stroke Biochim. Biophys. Acta 2007 1772 484 493 10.1016/j.bbadis.2006.11.009 17241774
Marlier Q. D’Aes T. Verteneuil S. Vandenbosch R. Malgrange B. Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons Cell Mol. Life Sci. 2020 77 4553 4571 10.1007/s00018-020-03548-1 32476056
Herrup K. Yang Y. Cell cycle regulation in the postmitotic neuron: Oxymoron or new biology? Nat. Rev. Neurosci. 2007 8 368 378 10.1038/nrn2124 17453017
Osuga H. Osuga S. Wang F. Fetni R. Hogan M.J. Slack R.S. Hakim A.M. Ikeda J.E. Park D.S. Cyclin-dependent kinases as a therapeutic target for stroke Proc. Natl. Acad. Sci. USA 2000 97 10254 10259 10.1073/pnas.170144197
Katchanov J. Harms C. Gertz K. Hauck L. Waeber C. Hirt L. Priller J. von Harsdorf R. Bruck W. Hortnagl H. et al. Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death J. Neurosci. 2001 21 5045 5053 10.1523/JNEUROSCI.21-14-05045.2001 11438580
Menn B. Bach S. Blevins T.L. Campbell M. Meijer L. Timsit S. Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models PLoS ONE 2010 5 e12117 10.1371/journal.pone.0012117 20711428
Cho B.B. Toledo-Pereyra L.H. Caspase-independent programmed cell death following ischemic stroke J. Investig. Surg. 2008 21 141 147 10.1080/08941930802029945
Bahatyrevich-Kharitonik B. Medina-Guzman R. Flores-Cortes A. Garcia-Cruzado M. Kavanagh E. Burguillos M.A. Cell Death Related Proteins Beyond Apoptosis in the CNS Front. Cell Dev. Biol. 2021 9 825747 10.3389/fcell.2021.825747
Dehkordi M.H. Munn R.G.K. Fearnhead H.O. Non-Canonical Roles of Apoptotic Caspases in the Nervous System Front. Cell Dev. Biol. 2022 10 840023 10.3389/fcell.2022.840023
Barnabe-Heider F. Wasylnka J.A. Fernandes K.J. Porsche C. Sendtner M. Kaplan D.R. Miller F.D. Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1 Neuron 2005 48 253 265 10.1016/j.neuron.2005.08.037
Hong Y. Liu Q. Peng M. Bai M. Li J. Sun R. Guo H. Xu P. Xie Y. Li Y. et al. High-frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats J. Neuroinflammation 2020 17 150 10.1186/s12974-020-01747-y 32375835
Jones P.A. May G.R. McLuckie J.A. Iwashita A. Sharkey J. Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia Cell Res. 2004 14 241 250 10.1038/sj.cr.7290225 15225418
Harms K.M. Li L. Cunningham L.A. Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1alpha-regulated VEGF signaling PLoS ONE 2010 5 e9767 10.1371/journal.pone.0009767 20339541
Koh J.Y. Wie M.B. Gwag B.J. Sensi S.L. Canzoniero L.M. Demaro J. Csernansky C. Choi D.W. Staurosporine-induced neuronal apoptosis Exp. Neurol. 1995 135 153 159 10.1006/exnr.1995.1074
Ansari B. Coates P.J. Greenstein B.D. Hall P.A. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states J. Pathol. 1993 170 1 8 10.1002/path.1711700102
Dmitrieva N.I. Burg M.B. Osmotic stress and DNA damage Methods Enzymol. 2007 428 241 252 10.1016/S0076-6879(07)28013-9
Gendron T.F. Mealing G.A. Paris J. Lou A. Edwards A. Hou S.T. MacManus J.P. Hakim A.M. Morley P. Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice J. Neurochem. 2001 78 316 324 10.1046/j.1471-4159.2001.00423.x
Linkermann A. Green D.R. Necroptosis N. Engl. J. Med. 2014 370 455 465 10.1056/NEJMra1310050
Vercammen D. Beyaert R. Denecker G. Goossens V. Van Loo G. Declercq W. Grooten J. Fiers W. Vandenabeele P. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor J. Exp. Med. 1998 187 1477 1485 10.1084/jem.187.9.1477
Qin Q. Yu N. Gu Y. Ke W. Zhang Q. Liu X. Wang K. Chen M. Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury Cell Death Dis. 2022 13 507 10.1038/s41419-022-04911-9
Degterev A. Huang Z. Boyce M. Li Y. Jagtap P. Mizushima N. Cuny G.D. Mitchison T.J. Moskowitz M.A. Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Nat. Chem. Biol. 2005 1 112 119 10.1038/nchembio711 16408008
Fujikawa D.G. The role of excitotoxic programmed necrosis in acute brain injury Comput. Struct. Biotechnol. J. 2015 13 212 221 10.1016/j.csbj.2015.03.004 25893083
He G. Yang X. Wang G. Qi J. Mao R. Wu Z. Zhou Z. Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory Front. Mol. Neurosci. 2017 10 365 10.3389/fnmol.2017.00365 29163040
Olson C.M. Liang Y. Leggett A. Park W.D. Li L. Mills C.E. Elsarrag S.Z. Ficarro S.B. Zhang T. Duster R. et al. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype Cell Chem. Biol. 2019 26 792 803.e710 10.1016/j.chembiol.2019.02.012 30905681
Kwiatkowski N. Zhang T. Rahl P.B. Abraham B.J. Reddy J. Ficarro S.B. Dastur A. Amzallag A. Ramaswamy S. Tesar B. et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor Nature 2014 511 616 620 10.1038/nature13393
Christensen C.L. Kwiatkowski N. Abraham B.J. Carretero J. Al-Shahrour F. Zhang T. Chipumuro E. Herter-Sprie G.S. Akbay E.A. Altabef A. et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor Cancer Cell 2014 26 909 922 10.1016/j.ccell.2014.10.019
Dion V. Schumacher N. Masar N. Pieltain A. Tocquin P. Lesoinne P. Malgrange B. Vandenbosch R. Franzen R. Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression Glia 2022 70 1652 1665 10.1002/glia.24186
Colleoni B. Paternot S. Pita J.M. Bisteau X. Coulonval K. Davis R.J. Raspe E. Roger P.P. JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21 Oncogene 2017 36 4349 4361 10.1038/onc.2017.7
Goebbels S. Bormuth I. Bode U. Hermanson O. Schwab M.H. Nave K.A. Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice Genesis 2006 44 611 621 10.1002/dvg.20256