Paper published in a journal (Scientific congresses and symposiums)
18FDG PET scanner as a selection criterion in liver transplantation for hepatocarcinoma
LAMBRECHT, Céline; Vandermeulen, Morgan; DELBOUILLE, Marie-Hélène et al.
2023In Acta Gastro-Enterologica Belgica, 86 (1), p. 17
Peer Reviewed verified by ORBi
 

Files


Full Text
A17.pdf
Author postprint (130.22 kB)
Download
Annexes
A17.BWG2023.HCCPET.23.orbi.pdf
(558.19 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
cancer; foie; greffe
Abstract :
[en] For years, Milan criteria have been the standard for selection criteria for liver transplantation (LT) of patients with hepatocellular carcinoma (HCC). Previous retrospective studies suggested that 18 FDG positron tomography (18FDG-PET) could be an effective tool to select HCC patients beyond Milan criteria for LT if their tumour is not FDG avid. A prospective national study evaluating the potential role of 18FDG-PET in LT for HCC was initiated by BeLIAC and financed by the National Cancer Foundation for the years 2019-2022. Complete results of this study with 2-year follow-up will be available by the end of 2024. In this report the authors aimed to present the preliminary results of this study in the CHU Liege LT centre. Methods: This study is a prospective national study accepted by all Belgian transplant centres and BeLIAC. All patients signed an informed consent form. Between January 2019 and October 2022, 51 patients (43 males, mean age 63y) were transplanted with HCC, and 44 had PET CT before LT or neoadjuvant therapy. Amongst these 44 HCC patients with PET, 28 were Milan-in, 1 Milan-in after successful downstaging, and 13 were Milan-out (11 Milan-out Up-to-seven-in and 2 Milan-out up-to-seven-out) at time of listing. Two Milan-in patients were PET positive, and all others were PET negative. Results: Three patients died during the follow-up, without recurrence. No patients developed recurrence at 1- and 2-year follow-up. Three patients developed recurrence between 2- and 3-year follow-up and all were Milan-in. Importantly, no Milan-out PET negative patients developed recurrence at October 2022 follow-up. Conclusions: PET FDG could be an important tool to offer potential LT opportunity to HCC patients outside Milan criteria. A longer follow-up and complete Belgian data are important before drawing further conclusions on this important matter.
Disciplines :
Surgery
Oncology
Gastroenterology & hepatology
Author, co-author :
LAMBRECHT, Céline ;  Centre Hospitalier Universitaire de Liège - CHU > > Unité de pédiatrie +3 et +4 NDB
Vandermeulen, Morgan ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
DELBOUILLE, Marie-Hélène ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
MONARD, Josée ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
WARMOES, Audrey ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
AMICONE, Caroline ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Warling, Odile ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Lamproye, Anne ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Delwaide, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
MEURISSE, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Honoré, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Hustinx, Roland  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Lovinfosse, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
More authors (4 more) Less
Language :
English
Title :
18FDG PET scanner as a selection criterion in liver transplantation for hepatocarcinoma
Publication date :
March 2023
Event name :
XXXVth Belgian Week of Gastroenterology
Event organizer :
Société Royale Belge de Gastroenterologie
Event place :
Anvers, Belgium
Event date :
du 8 au 10 mars 2023
Journal title :
Acta Gastro-Enterologica Belgica
ISSN :
0001-5644
eISSN :
1784-3227
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
86
Issue :
1
Pages :
A17
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fondation contre la Cancer
Available on ORBi :
since 11 April 2023

Statistics


Number of views
50 (7 by ULiège)
Number of downloads
24 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi