Place des biomarqueurs dans le dépistage du SAHOS. Une revue narrative de la littérature.

Biomarkers; Biomarqueurs; Dépistage de masse; Mass screening; Médecine personnalisée; Obstructive sleep apnea; Personalized medicine; Syndrome d’apnées et d’hypopnées obstructives du sommeil; Humans; Polysomnography; Cardiovascular System; Hypertension; Sleep Apnea, Obstructive/complications; Sleep Apnea, Obstructive/diagnosis; Sleep Apnea, Obstructive/epidemiology; Sleep Apnea, Obstructive; Pulmonary and Respiratory Medicine

Abstract :

[en] [en] INTRODUCTION: Obstructive sleep apnoea (OSA) is a common sleep-related breath disorder associated with cardiovascular and cerebrovascular complications, such as hypertension, arrhythmia, coronary artery disease and stroke. Unfortunately, OSA is underdiagnosed. BACKGROUND: Because of its clinical and therapeutic variability, OSA could benefit a personalized medicine approach. Diagnosis with polysomnography is expensive and access is limited. Clinical scoring systems allow screening of OSA, but many limitations exist. Because of this, biomarkers could be useful for the detection of OSA. OUTLOOK: Biomarkers specific to OSA would allow for better mass screening and more personalized treatment of the disease. This narrative review of the literature aims to summarize the biomarkers already described for the diagnosis of OSA and clarify both their advantages and limitations in daily practice. CONCLUSIONS: Our review of the literature did not actually identify an ideal biomarker even if promising research is ongoing.

Disciplines :

Neurology
Anesthesia & intensive care

Author, co-author :

Hauquiert, B; Département d'anesthésie-réanimation, Université catholique de Louvain, Bruxelles, Belgique

Drion, Emilie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie

Deflandre, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation ; Chef de service et maître de stages, Département d'anesthésie-réanimation, Clinique Saint-Luc-de-Bouge, Namur, Belgique. Electronic address: eric.deflandre@gmail.com

Language :

French

Title :

Place des biomarqueurs dans le dépistage du SAHOS. Une revue narrative de la littérature.

Alternative titles :

[en] The role of biomarkers in the detection of the OSA syndrome. A narrative review of the literature.

Publication date :

May 2021

Journal title :

Revue des Maladies Respiratoires

ISSN :

0761-8425

eISSN :

1776-2588

Publisher :

Elsevier Masson s.r.l., France

Volume :

Issue :

Pages :

455 - 465

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0761842521002229?httpAccept=text/xml

Data Set :

10.1016/j.rmr.2021.04.005

Available on ORBi :

since 10 April 2023

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187 (4 by ULiège)

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Bibliography

Lavie, L., Oxidative stress in obstructive sleep apnea and intermittent hypoxia – revisited – the bad ugly and good: implications to the heart and brain. Sleep Med Rev 20 (2015), 27–45.
Kapur, V.K., Auckley, D.H., Chowdhuri, S., et al. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med 13 (2017), 479–504.
Jackson, M.L., Howard, M.E., Barnes, M., Cognition and daytime functioning in sleep-related breathing disorders. Prog Brain Res 190 (2011), 53–68.
Peppard, P.E., Young, T., Barnet, J.H., et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177 (2013), 1006–1014.
Heinzer, R., Vat, S., Marques-Vidal, P., et al. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med 3 (2015), 310–318.
Mutter, T.C., Chateau, D., Moffatt, M., et al. A matched cohort study of postoperative outcomes in obstructive sleep apnea: could preoperative diagnosis and treatment prevent complications?. Anesthesiology 121 (2014), 707–718.
Chan, M.T.V., Wang, C.Y., Seet, E., et al. Association of unrecognized obstructive sleep apnea with postoperative cardiovascular events in patients undergoing major non-cardiac surgery. JAMA 321 (2019), 1788–1798.
Société de pneumologie de langue française, Société française d'anesthésie réanimation, Société française de cardiologie., et al. Recommendations for clinical practice. Obstructive sleep apnea hypopnea syndrome in adults. Rev Mal Respir 27 (2010), 806–833.
Deflandre, E., Degey, S., Opsomer, N., et al. Obstructive sleep apnea and smoking as a risk factor for venous thromboembolism events: review of the literature on the common pathophysiological mechanisms. Obes Surg 26 (2016), 640–648.
Deflandre, E.P., Bonhomme, V.L., Brichant, J.F., et al. What mediates postoperative risk in obstructive sleep apnea: airway obstruction, nocturnal hypoxia, or both?. Can J Anaesth 63 (2016), 1104–1105.
Ramachandran, S.K., Kheterpal, S., Consens, F., et al. Derivation and validation of a simple perioperative sleep apnea prediction score. Anesth Analg 110 (2010), 1007–1015.
Deflandre, E., Degey, S., Brichant, J.F., et al. Development and validation of a morphologic obstructive sleep apnea prediction score: the DES-OSA score. Anesth Analg 122 (2016), 363–372.
Chung, F., Subramanyam, R., Liao, P., et al. High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth 108 (2012), 768–775.
Deflandre, E., Degey, S., Brichant, J.F., et al. Preoperative ability of clinical scores to predict obstructive sleep apnea (OSA) severity in susceptible surgical patients. Obes Surg 27 (2017), 716–729.
Pevernagie, D.A., Gnidovec-Strazisar, B., Grote, L., et al. On the rise and fall of the apnea–hypopnea index: a historical review and critical appraisal. J Sleep Res, 29, 2020, e13066.
Deflandre, E., Brichant, J.-F., Obstructive sleep apnoea and postoperative complications: a significant link?. Anaesth Crit Care Pain Med 38 (2019), 431–433.
Bailly, S., Destors, M., Grillet, Y., et al. Obstructive sleep apnea: a cluster analysis at time of diagnosis. PloS one, 11, 2016, e0157318.
Gagnadoux, F., Le Vaillant, M., Paris, A., et al. Relationship between OSA clinical phenotypes and CPAP treatment outcomes. Chest 149 (2016), 288–290.
Zinchuk, A.V., Gentry, M.J., Concato, J., et al. Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches. Sleep Med Rev 35 (2017), 113–123.
Pien, G.W., Ye, L., Keenan, B.T., et al. Changing faces of obstructive sleep apnea: treatment effects by cluster designation in the Icelandic sleep apnea cohort. Sleep, 41, 2018, zsx201.
Biomarkers definitions working group., Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69 (2001), 89–95.
Maeder, M.T., Mueller, C., Schoch, O.D., et al. Biomarkers of cardiovascular stress in obstructive sleep apnea. Clin Chim Acta 460 (2016), 152–163.
Montesi, S.B., Bajwa, E.K., Malhotra, A., Biomarkers of sleep apnea. Chest 142 (2012), 239–245.
Lebkuchen, A., Freitas, L.S., Cardozo, K.H.M., et al. Advances and challenges in pursuing biomarkers for obstructive sleep apnea: implications for the cardiovascular risk. Trends Cardiovasc Med 3005 (2020), 7–8.
Baessler, A., Nadeem, R., Harvey, M., et al. Treatment for sleep apnea by continuous positive airway pressure improves levels of inflammatory markers – a meta-analysis. J Inflamm (Lond), 10, 2013, 13.
Khurana, S., Sharda, S., Saha, B., et al. Canvassing the aetiology, prognosis and molecular signatures of obstructive sleep apnoea. Biomarkers 24 (2019), 1–16.
Ning, Y., Zhang, T.-S., Wen, W.-W., et al. Effects of continuous positive airway pressure on cardiovascular biomarkers in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials. Sleep Breath 23 (2019), 77–86.
Van der Touw, T., Andronicos, N.M., Smart, N., Is C-reactive protein elevated in obstructive sleep apnea? A systematic review and meta-analysis. Biomarkers 24 (2019), 429–435.
Kheirandish-Gozal, L., Gozal, D., Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines. Int J Mol Sci, 20, 2019, 459.
Kaushal, N., Ramesh, V., Gozal, D., TNF-α and temporal changes in sleep architecture in mice exposed to sleep fragmentation. PLoS One, 7, 2012, e45610.
Ramesh, V., Nair, D., Zhang, S.X.L., et al. Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway. J Neuroinflammation, 9, 2012, 91.
Patel, S.R., Zhu, X., Storfer-Isser, A., et al. Sleep duration and biomarkers of inflammation. Sleep 32 (2009), 200–204.
Vgontzas, A.N., Zoumakis, E., Bixler, E.O., et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89 (2004), 2119–2126.
Steiropoulos, P., Papanas, N., Nena, E., et al. Inflammatory markers in middle-aged obese subjects: does obstructive sleep apnea syndrome play a role?. Mediators Inflamm, 2010, 2010, 675320.
Xie, X., Pan, L., Ren, D., et al. Effects of continuous positive airway pressure therapy on systemic inflammation in obstructive sleep apnea: a meta-analysis. Sleep Med 14 (2013), 1139–1150.
Nadeem, R., Harvey, M., Singh, M., et al. Patients with obstructive sleep apnea display increased carotid intima media: a meta-analysis. Int J Vasc Med, 2013, 2013, 839582.
Yudkin, J.S., Kumari, M., Humphries, S.E., et al. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis 148 (2000), 209–214.
Esteve, E., Castro, A., López-Bermejo, A., et al. Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity. Diabetes Care 30 (2007), 939–945.
Nadeem, R., Molnar, J., Madbouly, E.M., et al. Serum inflammatory markers in obstructive sleep apnea: a meta-analysis. J Clin Sleep Med 9 (2013), 1003–1012.
Zhang, D., Luo, J., Qiao, Y., et al. Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea: a meta-analysis. Medicine, 96, 2017, e6429.
Haight, J.S.J., Djupesland, P.G., Nitric oxide (NO) and obstructive sleep apnea (OSA). Sleep Breath 7 (2003), 53–62.
Cintra, F., Tufik, S., D'Almeida, V., et al. Cysteine: a potential biomarker for obstructive sleep apnea. Chest 139 (2011), 246–252.
Lavie, L., Perelman, A., Lavie, P., Plasma homocysteine levels in obstructive sleep apnea: association with cardiovascular morbidity. Chest 120 (2001), 900–908.
Kokturk, O., Ciftci, T.U., Mollarecep, E., et al. Serum homocysteine levels and cardiovascular morbidity in obstructive sleep apnea syndrome. Respir Med 100 (2006), 536–541.
Nihei, S.-I., Tasaki, H., Yamashita, K., et al. Hyperhomocysteinemia is associated with human coronary atherosclerosis through the reduction of the ratio of endothelium-bound to basal extracellular superoxide dismutase. Circ J 68 (2004), 822–828.
Svatikova, A., Wolk, R., Magera, M.J., et al. Plasma homocysteine in obstructive sleep apnoea. Eur Heart J 25 (2004), 1325–1329.
Varikasuvu, S.R., Dutt, N., Sahu, D., Obstructive sleep apnea and the effect of CPAP treatment on ischemia-modified albumin levels: a multi effect size meta-analysis with diagnostic test accuracy. Sleep Breath 23 (2019), 179–191.
Javaheri, S., Redline, S., Insomnia and risk of cardiovascular disease. Chest 152 (2017), 435–444.
Lombardi, C., Pengo, M.F., Parati, G., Obstructive sleep apnea syndrome and autonomic dysfunction. Auton Neurosci, 221, 2019, 102563.
Papanas, N., Steiropoulos, P., Nena, E., et al. HbA1c is associated with severity of obstructive sleep apnea hypopnea syndrome in non-diabetic men. Vasc Health Risk Manag 5 (2009), 751–756.
Pallayova, M., Steele, K.E., Magnuson, T.H., et al. Sleep apnea predicts distinct alterations in glucose homeostasis and biomarkers in obese adults with normal and impaired glucose metabolism. Cardiovasc Diabetol 9 (2010), 1–11.
Morgenstern, M., Wang, J., Beatty, N., et al. Obstructive sleep apnea: an unexpected cause of insulin resistance and diabetes. Endocrinol Metab Clin North Am 43 (2014), 187–204.
Greco, C., Spallone, V., Obstructive sleep apnoea syndrome and diabetes. Fortuitous association or interaction?. Curr Diabetes Rev 12 (2015), 129–155.
DeMartino, T., Ghoul, R.E., Wang, L., et al. Oxidative stress and inflammation differentially elevated in objective versus habitual subjective reduced sleep duration in obstructive sleep apnea. Sleep 39 (2016), 1361–1369.
Hanikoglu, F., Huseyinoglu, N., Ozben, S., et al. Increased plasma soluble tumor necrosis factor receptor-1 and myeloperoxidase activity in patients with obstructive sleep apnea syndrome. Int J Neurosci 125 (2015), 655–662.
Feres, M.C., Fonseca, F.A.H., Cintra, F.D., et al. An assessment of oxidized LDL in the lipid profiles of patients with obstructive sleep apnea and its association with both hypertension and dyslipidemia, and the impact of treatment with CPAP. Atherosclerosis 241 (2015), 342–349.
Sarrazin, S., Adam, E., Lyon, M., et al. Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy. Biochim Biophys Acta 1765 (2006), 25–37.
Balta, S., Mikhailidis, D.P., Demirkol, S., et al. Endocan: a novel inflammatory indicator in cardiovascular disease?. Atherosclerosis 243 (2015), 339–343.
Altintas, N., Mutlu, L.C., Akkoyun, D.C., et al. Effect of CPAP on new endothelial dysfunction marker, endocan, in people with obstructive sleep apnea. Angiology 67 (2016), 364–374.
Lin, G., Chen, Q., Huang, J., et al. Effect of continuous positive airway pressure on endothelin-1 in patients with obstructive sleep apnea: a meta-analysis. Eur Arch Otorhinolaryngol 276 (2019), 623–630.
Zhang, X.-B., Jiang, X.-T., Cai, F.-R., et al. Vascular endothelial growth factor levels in patients with obstructive sleep apnea: a meta-analysis. Eur Arch Otorhinolaryngol 274 (2017), 661–670.
Jordan, A.S., McSharry, D.G., Malhotra, A., Adult obstructive sleep apnoea. Lancet 383 (2014), 736–747.
Santamaria-Martos, F., Benítez, I., Ortega, F., et al. Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis. Sci Rep, 9, 2019, 13456.
Freitas, L.S., Silveira, A.C., Martins, F.C., et al. Severe obstructive sleep apnea is associated with circulating microRNAs related to heart failure, myocardial ischemia, and cancer proliferation. Sleep Breath 24 (2020), 1463–1472.
Li, K., Chen, Z., Qin, Y., et al. MiR-664a-3p expression in patients with obstructive sleep apnea: a potential marker of atherosclerosis. Medicine, 97, 2018, e9813.
Khalyfa, A., Kheirandish-Gozal, L., Khalyfa, A.A., et al. Circulating plasma extracellular microvesicle microRNA cargo and endothelial dysfunction in children with obstructive sleep apnea. Am J Respir Crit Care Med 194 (2016), 1116–1126.
Khalyfa, A., Kheirandish-Gozal, L., Gozal, D., Circulating exosomes in obstructive sleep apnea as phenotypic biomarkers and mechanistic messengers of end-organ morbidity. Respir Physiol Neurobiol 256 (2018), 143–156.
Chen, W., Ye, J., Han, D., et al. Association of prepro-orexin polymorphism with obstructive sleep apnea/hypopnea syndrome. Am J Otolaryngol 33 (2012), 31–36.
Yin, T., Li, N.F., Heizhati, M., et al. Association of glucose transporter 4 genetic polymorphisms with obstructive sleep apnea syndrome in Han Chinese general population: a cross-section study. Lipids Health Dis 13 (2014), 1–9.
Bhushan, B., Guleria, R., Misra, A., et al. TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea. Respir Med 103 (2009), 386–392.
Khalyfa, A., Kheirandish-Gozal, L., Capdevila, O.S., et al. Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apnea. Pediatr Pulmonol 47 (2012), 1001–1011.
Bhushan, B., Khalyfa, A., Spruyt, K., et al. Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea. Sleep Med 12 (2011), 666–671.
Ferrarini, A., Rupérez, F.J., Erazo, M., et al. Fingerprinting-based metabolomic approach with LC-MS to sleep apnea and hypopnea syndrome: a pilot study. Electrophoresis 34 (2013), 2873–2881.
Xu, H., Zheng, X., Qian, Y., et al. Metabolomics profiling for obstructive sleep apnea and simple snorers. Sci Rep, 6, 2016, 30958.
Lebkuchen, A., Carvalho, V.M., Venturini, G., et al. Metabolomic and lipidomic profile in men with obstructive sleep apnoea: implications for diagnosis and biomarkers of cardiovascular risk. Sci Rep, 8, 2018, 11270.
Feliciano, A., Vaz, F., Valentim-Coelho, C., et al. Evening and morning alterations in obstructive sleep apnea red blood cell proteome. Data Brief 11 (2017), 103–110.
Chen, Y.-C., Hsu, P.-Y., Hsiao, C.-C., et al. Epigenetics: a potential mechanism involved in the pathogenesis of various adverse consequences of obstructive sleep apnea. Int J Mol Sci, 20, 2019, 2937.
Fleming, W.E., Ferouz-Colborn, A., Samoszuk, M.K., et al. Blood biomarkers of endocrine, immune, inflammatory, and metabolic systems in obstructive sleep apnea. Clin Biochem 49 (2016), 854–861.
Khalyfa, A., Gileles-Hillel, A., Gozal, D., The challenges of precision medicine in obstructive sleep apnea. Sleep Med Clin 11 (2016), 213–226.