Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

Serradji, Nawal; Bensaid, Okkacha; Martin, Marc; Sallem, Wafa; Dereuddre-Bosquet, Nathalie; Benmehdi, Houcine; Redeuilh, Catherine; Lamouri, Aazdine; Dive, Georges; Clayette, Pascal; Heymans, Françoise

doi:10.1016/j.bmc.2006.07.031

Article (Scientific journals)

Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

Serradji, Nawal; Bensaid, Okkacha; Martin, Marc et al.

2006 • In Bioorganic and Medicinal Chemistry, 14 (23), p. 8109-8125

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/30008

DOI
10.1016/j.bmc.2006.07.031

PubMed
16893650

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Keywords :

anti-HIV-1; anti-PAF; brain; AIDS dementia complex

Abstract :

[en] HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series. (c) 2006 Elsevier Ltd. All rights reserved.

Disciplines :

Biochemistry, biophysics & molecular biology
Chemistry
Pharmacy, pharmacology & toxicology

Author, co-author :

Serradji, Nawal

Bensaid, Okkacha

Martin, Marc

Sallem, Wafa

Dereuddre-Bosquet, Nathalie

Benmehdi, Houcine

Redeuilh, Catherine

Lamouri, Aazdine

Dive, Georges ; Université de Liège - ULiège > Centre d'ingénierie des protéines

Clayette, Pascal

Heymans, Françoise

Language :

English

Title :

Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

Publication date :

01 December 2006

Journal title :

Bioorganic and Medicinal Chemistry

ISSN :

0968-0896

eISSN :

1464-3391

Publisher :

Pergamon-Elsevier Science Ltd, Oxford, United Kingdom

Volume :

Issue :

Pages :

8109-8125

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

IAP

Available on ORBi :

since 28 November 2009

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