ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.
[en] ALK-negative anaplastic large cell lymphoma (ALCL) comprises subgroups harboring rearrangements of DUSP22 (DUSP22-R) or TP63 (TP63-R). Two studies respectively reported 90% and 40% 5-year overall survival (OS) in 21 and 12 DUSP22-R/TP63-not rearranged (NR) patients, making the prognostic impact of DUSP22-R unclear. Here, 104 newly diagnosed ALK-negative ALCL patients (including 37 from first-line clinical trials) from the LYSA TENOMIC database were analyzed by break-apart FISH assays for DUSP22-R and TP63-R. There were 47/104 (45%) DUSP22-R and 2/93 (2%) TP63-R cases, including one DUSP22-R/TP63-R. DUSP22-R tumors showed more frequent CD3 expression (62% versus 35%, P=0.01), and less commonly a cytotoxic phenotype (27% versus 82%; P.
Disciplines :
Hematology
Author, co-author :
Sibon, David; Lymphoid Malignancies Department, Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 94000 Créteil, France, Faculty of Medicine and Health, Campus Henri Mondor, Paris-Est Créteil University, 94000 Créteil. david.sibon@aphp.fr
Bisig, Bettina; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University
Bonnet, Christophe ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique ; Hematology Department, Liège University Hospital
Poullot, Elsa; Faculty of Medicine and Health, Campus Henri Mondor, Paris-Est Créteil University, 94000 Créteil, France, Department of Pathology, Henri Mondor University Hospital, Créteil
Bachy, Emmanuel; Hematology Department, Lyon-Sud University Hospital
Cavalieri, Doriane; Hematology Department, Clermont-Ferrand University Hospital
Fataccioli, Virginie; Faculty of Medicine and Health, Campus Henri Mondor, Paris-Est Créteil University, 94000 Créteil, France, Department of Pathology, Henri Mondor University Hospital, Créteil
Bregnard, Cloe; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University
Drieux, Fanny; Pathology Department, Henri Becquerel Cancer Center
Bruneau, Julie; Pathology Department, Necker University Hospital
Lemonnier, Francois; Lymphoid Malignancies Department, Henri-Mondor University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 94000 Créteil, France, Faculty of Medicine and Health, Campus Henri Mondor, Paris-Est Créteil University, 94000 Créteil
Dupuy, Aurelie; Faculty of Medicine and Health, Campus Henri Mondor, Paris-Est Créteil University, 94000 Créteil
Bossard, Celine; Pathology Department, Nantes University Hospital
Parrens, Marie; Pathology Department, Bordeaux University Hospital
Bouabdallah, Krimo; Hematology Department, Bordeaux University Hospital
Ketterer, Nicolas; Clinique Bois-Cerf, Lausanne
Berthod, Gregoire; Hospital Center for Valais Romand (CHVR), Martigny Hospital, CH-1920, Martigny
Cairoli, Anne; Service of Hematology, Department of Oncology, Lausanne University Hospital and Lausanne University, Lausanne
Damaj, Gandhi; Institut d'Hématologie de Basse-Normandie, Caen University Hospital
Tournilhac, Olivier; Hematology Department, Clermont-Ferrand University Hospital
Jais, Jean-Philippe; Department of Biostatistics, Necker University Hospital
Gaulard, Philippe; Faculty of Medicine and Health, Campus Henri Mondor, Paris-Est Créteil University, 94000 Créteil, France, Department of Pathology, Henri Mondor University Hospital, Créteil
De Leval, Laurence; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University. Laurence.DeLeval@chuv.ch
ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.
