Structure-activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity
piperazine; anti-PAF; anti-HIV-1; AIDS dementia complex
Abstract :
[en] As HIV-associated dementia prevalence has risen with the lifespan of HIV-infected individuals, there is an important need for antiretroviral and anti-inflammatory drugs targeting the central nervous system. Platelet-activating factor, a mediator of inflammation, is an HIV-induced neurotoxin secreted in the infected brain. In this work, we developed piperazine derivatives bearing a heterocyclic moiety as PAF-antagonists and HIV-1 replication inhibitors with micromolar potency. (c) 2006 Elsevier Ltd. All rights reserved.
Dive, Georges ; Université de Liège - ULiège > Centre d'ingénierie des protéines
Clayette, Pascal
Heymans, Françoise
Language :
English
Title :
Structure-activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity
Publication date :
01 December 2006
Journal title :
Bioorganic and Medicinal Chemistry
ISSN :
0968-0896
eISSN :
1464-3391
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
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