Article (Scientific journals)
Lipid Metabolism Heterogeneity and Crosstalk with Mitochondria Functions Drive Breast Cancer Progression and Drug Resistance.
Azam, Aurélien; Sounni, Nor Eddine
2022In Cancers, 14 (24), p. 6267
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Keywords :
breast cancer; cancer progression; drug resistance; heterogeneity; hypoxia; lipid metabolism; oxidative stress; tumor microenvironment; Oncology; Cancer Research
Abstract :
[en] Breast cancer (BC) is a heterogeneous disease that can be triggered by genetic alterations in mammary epithelial cells, leading to diverse disease outcomes in individual patients. The metabolic heterogeneity of BC enhances its ability to adapt to changes in the tumor microenvironment and metabolic stress, but unfavorably affects the patient's therapy response, prognosis and clinical effect. Extrinsic factors from the tumor microenvironment and the intrinsic parameters of cancer cells influence their mitochondrial functions, which consequently alter their lipid metabolism and their ability to proliferate, migrate and survive in a harsh environment. The balanced interplay between mitochondria and fatty acid synthesis or fatty acid oxidation has been attributed to a combination of environmental factors and to the genetic makeup, oncogenic signaling and activities of different transcription factors. Hence, understanding the mechanisms underlying lipid metabolic heterogeneity and alterations in BC is gaining interest as a major target for drug resistance. Here we review the major recent reports on lipid metabolism heterogeneity and bring to light knowledge on the functional contribution of diverse lipid metabolic pathways to breast tumorigenesis and therapy resistance.
Disciplines :
Oncology
Author, co-author :
Azam, Aurélien  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology
Sounni, Nor Eddine  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire
Language :
English
Title :
Lipid Metabolism Heterogeneity and Crosstalk with Mitochondria Functions Drive Breast Cancer Progression and Drug Resistance.
Publication date :
19 December 2022
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
MDPI, Switzerland
Volume :
14
Issue :
24
Pages :
6267
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Funding text :
This research was supported by grants from the National Fund for Scientific Research (FRS-FNRS), Belgium, PDR # T.023020; PDR-TLV; CDR# J.0178.22, CDR#32801162. Grant from Breast Cancer Now UK, # 2018NovPCC1285. Grants from University of Liège, credit sectorial and from Leon Fredericq Foundation, Liège, Belgium.
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