Article (Scientific journals)
Radiotherapy Advances in Renal Disease—Focus on Renal Ischemic Preconditioning
Khbouz, Badr; Gu, Shiyang; Pinto Coelho, Tiago et al.
2023In Bioengineering, 10 (1), p. 68
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Keywords :
irradiation; radiotherapy; kidney diseases; preconditionning
Abstract :
[en] Ionizing irradiation is widely applied as a fundamental therapeutic treatment in several diseases. Acute kidney injury (AKI) represents a global public health problem with major morbidity and mortality. Renal ischemia/reperfusion (I/R) is the main cause of AKI. I/R injury occurs when blood flow to the kidney is transiently interrupted and then restored. Such an ischemic insult significantly impairs renal function in the short and long terms. Renal ischemic preconditioning (IPC) corresponds to the maneuvers intended to prevent or attenuate the ischemic damage. In murine models, irradiation-induced preconditioning (IP) renders the renal parenchyma resistant to subsequent damage by activating defense pathways involved in oxidative stress, angiogenesis, and inflammation. Before envisioning translational applications in patients, safe irradiation modalities, including timing, dosage, and fractionation, need to be defined.
Disciplines :
Urology & nephrology
Author, co-author :
Khbouz, Badr  ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Gu, Shiyang
Pinto Coelho, Tiago  ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
LALLEMAND, François  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiothérapie
Jouret, François  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Language :
English
Title :
Radiotherapy Advances in Renal Disease—Focus on Renal Ischemic Preconditioning
Publication date :
05 January 2023
Journal title :
Bioengineering
eISSN :
2306-5354
Publisher :
MDPI AG
Volume :
10
Issue :
1
Pages :
68
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fund for Scientific Research [BE]
ULiège - University of Liège [BE]
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since 16 January 2023

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