[en] Lung cancer is the third most common cancer in Belgium in 2017 and remains the leading cause of cancer death worldwide. There is no longer any doubt that the main cause of lung cancer is smoking. However, the prevalence of lung cancer in never-smokers has been increasing overtime. Moreover, it is now recognized that the lung cancer of non-smoker patients has very distinct characteristics. In this retrospective cohort study (N = 520), we describe the characteristics of non-smoker patients and their non-small cell lung carcinoma and compare them to those of smokers. The patients included in this study were whose with a new diagnostic of lung cancer made at the Liège University Hospital of Liège over 2 years round. Non small cell lung cancer occurring in never-smokers patients is more often seen in young and very old patients, more frequent in female, essentially adenocarcinoma and often associated with mutations. This work confirms that lung cancer in never-smokers shows different features than lung cancer seen in patients with a smoking history. [fr] Le cancer pulmonaire est le troisième cancer le plus fréquent en Belgique en 2017 et reste la première cause de décès par cancer dans le monde. Il ne fait plus aucun doute que la cause principale de cancer du poumon est le tabagisme. Il est toutefois apparu, ces dernières décennies, que le pourcentage de patients non fumeurs augmente parmi les patients présentant un cancer du poumon. Par ailleurs, il est dorénavant reconnu que le cancer pulmonaire du patient non fumeur présente des caractéristiques bien distinctes. Dans ce contexte, nous présentons une étude rétrospective reprenant les caractéristiques cliniques et néoplasiques de l’ensemble des patients ayant présenté un carcinome pulmonaire non à petites cellules dans notre institution sur une période de 2 ans (N = 520). Les cancers non à petites cellules observés chez les nonfumeurs sont plus fréquents chez les sujets jeunes ou très âgés, plus fréquents dans le sexe féminin, en très grande majorité des adénocarcinomes, et souvent associés à des mutations. Nous confirmons ainsi qu’il s’agit d’un cancer aux caractéristiques différentes des cancers pulmonaires des patients fumeurs.
Disciplines :
Oncology
Author, co-author :
Debruche, M; Service de Pneumologie, CHR Citadelle, Liège, Belgique
Mettlen, C; Service de Pneumologie, CHU Liège, Belgique
PAULUS, Astrid ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
VAILLANT, Frédérique ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Sibille, Anne ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Freres, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale
Duysinx, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Language :
French
Title :
Cancer pulmonaire non à petites cellules chez les patients non fumeurs au CHU de Liège : étude rétrospective entre début 2017 et fin 2018.
Alternative titles :
[en] Non small cell lung carcinoma in never-smokers at the Liege University Hospital : a retrospective cohort study, 2017-2018.
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