Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores.
De Voeght, Adrien; WILLEMS, Evelyne; Servais, Sophieet al.
PICAT; SOFA; allogeneic stem cell transplantation; intensive care; prognostic score; Oncology; Cancer Research
Abstract :
[en] Background. Allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients requiring intensive care unit (ICU) have high mortality rates. Methods. In the current study, we retrospectively assessed whether the Prognostic Index for Critically Ill Allogeneic Transplantation patients (PICAT) score predicted overall survival in a cohort of 111 consecutive allo-HCT recipients requiring ICU. Results. Survival rates at 30 days and 1 year after ICU admission were 57.7% and 31.5%, respectively, and were significantly associated with PICAT scores (p = 0.036). Specifically, survival at 30-day for low, intermediate, and high PICAT scores was 64.1%, 58.1%, and 31.3%, respectively. At one-year, the figures were 37.5%, 29%, and 12.5%, respectively. In multivariate analyses, high PICAT score (HR = 2.23, p = 0.008) and relapse prior to ICU admission (HR = 2.98, p = 0.0001) predicted higher mortality. We next compared the ability of the PICAT and the Sequential Organ Failure Assessment (SOFA) scores to predict mortality in our patients using c-statistics. C statistics for the PICAT and the SOFA scores were 0.5687 and 0.6777, respectively. Conclusions. This study shows that while the PICAT score is associated with early and late mortality in allo-HCT recipients requiring ICU, it is outperformed by the SOFA score to predict their risk of mortality.
Disciplines :
Hematology
Author, co-author :
De Voeght, Adrien ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
WILLEMS, Evelyne ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Servais, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Seidel, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Pirotte, Michelle ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Massion, Paul ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Layios, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Pereira, Maguy; Department of Medicine, Division of Hematology, Centre Hospitalier Universitaire de Liège, University of Liège, 4000 Liège, Belgium
Misset, Benoît ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
CANIVET, Jean-Luc ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Beguin, Yves ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Baron, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Language :
English
Title :
Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores.
Styczyński J. Tridello G. Koster L. Iacobelli S. van Biezen A. van der Werf S. Mikulska M. Gil L. Cordonnier C. Ljungman P. et al. Death after Hematopoietic Stem Cell Transplantation: Changes over Calendar Year Time, Infections and Associated Factors Bone Marrow Transplant. 2020 55 126 136 10.1038/s41409-019-0624-z 31455899
Carreras E. Dufour C. Mohty M. Kröger N. The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies 7th ed. Springer Cham, Switzerland 2019 978-3-030-02277-8
Versluis J. In ’t Hout F.E.M. Devillier R. van Putten W.L.J. Manz M.G. Vekemans M.-C. Legdeur M.-C. Passweg J.R. Maertens J. Kuball J. et al. Comparative Value of Post-Remission Treatment in Cytogenetically Normal AML Subclassified by NPM1 and FLT3-ITD Allelic Ratio Leukemia 2017 31 26 33 10.1038/leu.2016.183 27416910
Baron F. Efficace F. Cannella L. Willemze R. Vignetti M. Muus P. Marie J.-P. Ferrero D. Fazi P. La Sala E. et al. Long-Term Follow-up of a Trial Comparing Post-Remission Treatment with Autologous or Allogeneic Bone Marrow Transplantation or Intensive Chemotherapy in Younger Acute Myeloid Leukemia Patients Haematologica 2020 105 e13 e16 10.3324/haematol.2019.221333 31097634
Saillard C. Darmon M. Bisbal M. Sannini A. Chow-Chine L. Faucher M. Lengline E. Vey N. Blaise D. Azoulay E. et al. Critically Ill Allogenic HSCT Patients in the Intensive Care Unit: A Systematic Review and Meta-Analysis of Prognostic Factors of Mortality Bone Marrow Transplant. 2018 53 1233 1241 10.1038/s41409-018-0181-x 29703972
van der Heiden P.L.J. Arbous M.S. van Beers E.J. van den Bergh W.M. le Cessie S. Demandt A.M.P. Eefting M. Hess C. Kusadasi N. Marijt W.A.F. et al. Predictors of Short-Term and Long-Term Mortality in Critically Ill Patients Admitted to the Intensive Care Unit Following Allogeneic Stem Cell Transplantation Bone Marrow Transplant. 2019 54 418 424 10.1038/s41409-018-0277-3
Bayraktar U.D. Shpall E.J. Liu P. Ciurea S.O. Rondon G. de Lima M. Cardenas-Turanzas M. Price K.J. Champlin R.E. Nates J.L. Hematopoietic Cell Transplantation-Specific Comorbidity Index Predicts Inpatient Mortality and Survival in Patients Who Received Allogeneic Transplantation Admitted to the Intensive Care Unit Off. J. Am. Soc. Clin. Oncol. 2013 31 4207 4214 10.1200/JCO.2013.50.5867
Platon L. Amigues L. Ceballos P. Fegueux N. Daubin D. Besnard N. Larcher R. Landreau L. Agostini C. Machado S. et al. A Reappraisal of ICU and Long-Term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation Patients and Reassessment of Prognosis Factors: Results of a 5-Year Cohort Study (2009–2013) Bone Marrow Transplant. 2016 51 256 261 10.1038/bmt.2015.269
Benz R. Schanz U. Maggiorini M. Seebach J.D. Stussi G. Risk Factors for ICU Admission and ICU Survival after Allogeneic Hematopoietic SCT Bone Marrow Transplant. 2014 49 62 65 10.1038/bmt.2013.141
Gilli K. Remberger M. Hjelmqvist H. Ringden O. Mattsson J. Sequential Organ Failure Assessment Predicts the Outcome of SCT Recipients Admitted to Intensive Care Unit Bone Marrow Transplant. 2010 45 682 688 10.1038/bmt.2009.220
Sorror M.L. Maris M.B. Storb R. Baron F. Sandmaier B.M. Maloney D.G. Storer B. Hematopoietic Cell Transplantation (HCT)-Specific Comorbidity Index: A New Tool for Risk Assessment before Allogeneic HCT Blood 2005 106 2912 2919 10.1182/blood-2005-05-2004
Brissot E. Labopin M. Baron F. Bazarbachi A. Bug G. Ciceri F. Esteve J. Giebel S. Gilleece M.H. Gorin N.-C. et al. Management of Patients with Acute Leukemia during the COVID-19 Outbreak: Practical Guidelines from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation Bone Marrow Transplant. 2021 56 532 535 10.1038/s41409-020-0970-x 32528122
Przepiorka D. Weisdorf D. Martin P. Klingemann H.G. Beatty P. Hows J. Thomas E.D. 1994 Consensus Conference on Acute GVHD Grading Bone Marrow Transplant. 1995 15 825 828 7581076
Jagasia M.H. Greinix H.T. Arora M. Williams K.M. Wolff D. Cowen E.W. Palmer J. Weisdorf D. Treister N.S. Cheng G.-S. et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report Biol. Blood Marrow Transplant. 2015 21 389 401.e1 10.1016/j.bbmt.2014.12.001
Singer M. Deutschman C.S. Seymour C.W. Shankar-Hari M. Annane D. Bauer M. Bellomo R. Bernard G.R. Chiche J.-D. Coopersmith C.M. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA 2016 315 801 810 10.1001/jama.2016.0287
Armand P. Kim H.T. Logan B.R. Wang Z. Alyea E.P. Kalaycio M.E. Maziarz R.T. Antin J.H. Soiffer R.J. Weisdorf D.J. et al. Validation and Refinement of the Disease Risk Index for Allogeneic Stem Cell Transplantation Blood 2014 123 3664 3671 10.1182/blood-2014-01-552984
Vincent J.-L. de Mendonca A. Cantraine F. Moreno R. Takala J. Suter P.M. Sprung C.L. Colardyn F. Blecher S. Use of the SOFA Score to Assess the Incidence of Organ Dysfunction/Failure in Intensive Care Units: Results of a Multicenter, Prospective Study Crit. Care Med. 1998 26 1793 1800 10.1097/00003246-199811000-00016
Copelan E. Casper J.T. Carter S.L. van Burik J.-A.H. Hurd D. Mendizabal A.M. Wagner J.E. Yanovich S. Kernan N.A. A Scheme for Defining Cause of Death and Its Application in the T Cell Depletion Trial Biol. Blood Marrow Transplant. 2007 13 1469 1476 10.1016/j.bbmt.2007.08.047
Lindgaard S.C. Nielsen J. Lindmark A. Sengeløv H. Prognosis of Allogeneic Haematopoietic Stem Cell Recipients Admitted to the Intensive Care Unit: A Retrospective, Single-Centre Study Acta Haematol. 2016 135 72 78 10.1159/000440937
Naeem N. Eyzaguirre A. Kern J.A. Lazarus H.M. Hejal R.B. Laughlin M.J. Kern E.F.O. Outcome of Adult Umbilical Cord Blood Transplant Patients Admitted to a Medical Intensive Care Unit Bone Marrow Transplant. 2006 38 733 738 10.1038/sj.bmt.1705502
Lengliné E. Chevret S. Moreau A.-S. Pène F. Blot F. Bourhis J.-H. Buzyn A. Schlemmer B. Socié G. Azoulay E. Changes in Intensive Care for Allogeneic Hematopoietic Stem Cell Transplant Recipients Bone Marrow Transplant. 2015 50 840 845 10.1038/bmt.2015.55 25798675
Depuydt P. Kerre T. Noens L. Nollet J. Offner F. Decruyenaere J. Benoit D. Outcome in Critically Ill Patients with Allogeneic BM or Peripheral Haematopoietic SCT: A Single-Centre Experience Bone Marrow Transplant. 2011 46 1186 1191 10.1038/bmt.2010.255 21042315
Barrot L. Asfar P. Mauny F. Winiszewski H. Montini F. Badie J. Quenot J.-P. Pili-Floury S. Bouhemad B. Louis G. et al. Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome N. Engl. J. Med. 2020 382 999 1008 10.1056/NEJMoa1916431 32160661
Fujii T. Luethi N. Young P.J. Frei D.R. Eastwood G.M. French C.J. Deane A.M. Shehabi Y. Hajjar L.A. Oliveira G. et al. Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial JAMA 2020 323 423 10.1001/jama.2019.22176 31950979
Mokart D. Granata A. Crocchiolo R. Sannini A. Chow-Chine L. Brun J.-P. Bisbal M. Faucher M. Faucher C. Blache J.-L. et al. Allogeneic Hematopoietic Stem Cell Transplantation after Reduced Intensity Conditioning Regimen: Outcomes of Patients Admitted to Intensive Care Unit J. Crit. Care. 2015 30 1107 1113 10.1016/j.jcrc.2015.06.020
Michel C.S. Teschner D. Schmidtmann I. Theobald M. Hauptrock B. Wagner-Drouet E.M. Radsak M.P. Prognostic Factors and Outcome of Adult Allogeneic Hematopoietic Stem Cell Transplantation Patients Admitted to Intensive Care Unit during Transplant Hospitalization Sci. Rep. 2019 9 19911 10.1038/s41598-019-56322-0
Azoulay É. Mokart D. Lambert J. Lemiale V. Rabbat A. Kouatchet A. Vincent F. Gruson D. Bruneel F. Epinette-Branche G. et al. Diagnostic Strategy for Hematology and Oncology Patients with Acute Respiratory Failure: Randomized Controlled Trial Am. J. Respir. Crit. Care Med. 2010 182 1038 1046 10.1164/rccm.201001-0018OC
Lemiale V. Resche-Rigon M. Mokart D. Pène F. Rabbat A. Kouatchet A. Vincent F. Bruneel F. Nyunga M. Lebert C. et al. Acute Respiratory Failure in Patients with Hematological Malignancies: Outcomes According to Initial Ventilation Strategy. A Groupe de Recherche Respiratoire En Réanimation Onco-Hématologique (Grrr-OH) Study Ann. Intensive Care 2015 5 28 10.1186/s13613-015-0070-z
Rivers E. Nguyen B. Havstad S. Ressler J. Muzzin A. Knoblich B. Peterson E. Tomlanovich M. Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock N. Engl. J. Med. 2001 345 1368 1377 10.1056/NEJMoa010307
Turki A.T. Lamm W. Schmitt C. Bayraktar E. Alashkar F. Metzenmacher M. Wohlfarth P. Beelen D.W. Liebregts T. Platelet Number and Graft Function Predict Intensive Care Survival in Allogeneic Stem Cell Transplantation Patients Ann. Hematol. 2019 98 491 500 10.1007/s00277-018-3538-8
Kim D.H. Sohn S.K. Baek J.H. Kim J.G. Lee N.Y. Won D.I. Suh J.S. Lee K.B. Clinical Significance of Platelet Count at Day +60 After Allogeneic Peripheral Blood Stem Cell Transplantation J. Korean Med. Sci. 2006 21 46 51 10.3346/jkms.2006.21.1.46 16479064
Mielcarek M. Storer B.E. Flowers M.E.D. Storb R. Sandmaier B.M. Martin P.J. Outcomes among Patients with Recurrent High-Risk Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation Biol. Blood Marrow Transplant. 2007 13 1160 1168 10.1016/j.bbmt.2007.06.007 17889352
Canti L. Humblet-Baron S. Desombere I. Neumann J. Pannus P. Heyndrickx L. Henry A. Servais S. Willems E. Ehx G. et al. Predictors of Neutralizing Antibody Response to BNT162b2 Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Recipients J. Hematol. Oncol. 2021 14 174 10.1186/s13045-021-01190-3
Canti L. Ariën K.K. Desombere I. Humblet-Baron S. Pannus P. Heyndrickx L. Henry A. Servais S. Willems E. Ehx G. et al. Antibody Response against SARS-CoV-2 Delta and Omicron Variants after Third-Dose BNT162b2 Vaccination in Allo-HCT Recipients Cancer Cell. 2022 40 335 337 10.1016/j.ccell.2022.02.005 35172125
Catalano C. Servais S. Bonvoisin C. Couturier B. Hildebrand M. Etienne I. Meuris C. Goffard J.-C. Wissing M. Goldman M. et al. Preemptive Antibody Therapy for Vaccine Breakthrough SARS-CoV-2 Infection in Immunocompromised Patients Transplantation 2021 105 e282 10.1097/TP.0000000000003942