Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores.
De Voeght, Adrien; WILLEMS, Evelyne; Servais, Sophieet al.
PICAT; SOFA; allogeneic stem cell transplantation; intensive care; prognostic score; Oncology; Cancer Research
Résumé :
[en] Background. Allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients requiring intensive care unit (ICU) have high mortality rates. Methods. In the current study, we retrospectively assessed whether the Prognostic Index for Critically Ill Allogeneic Transplantation patients (PICAT) score predicted overall survival in a cohort of 111 consecutive allo-HCT recipients requiring ICU. Results. Survival rates at 30 days and 1 year after ICU admission were 57.7% and 31.5%, respectively, and were significantly associated with PICAT scores (p = 0.036). Specifically, survival at 30-day for low, intermediate, and high PICAT scores was 64.1%, 58.1%, and 31.3%, respectively. At one-year, the figures were 37.5%, 29%, and 12.5%, respectively. In multivariate analyses, high PICAT score (HR = 2.23, p = 0.008) and relapse prior to ICU admission (HR = 2.98, p = 0.0001) predicted higher mortality. We next compared the ability of the PICAT and the Sequential Organ Failure Assessment (SOFA) scores to predict mortality in our patients using c-statistics. C statistics for the PICAT and the SOFA scores were 0.5687 and 0.6777, respectively. Conclusions. This study shows that while the PICAT score is associated with early and late mortality in allo-HCT recipients requiring ICU, it is outperformed by the SOFA score to predict their risk of mortality.
Disciplines :
Hématologie
Auteur, co-auteur :
De Voeght, Adrien ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
WILLEMS, Evelyne ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Servais, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Seidel, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Pirotte, Michelle ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Massion, Paul ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Layios, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Pereira, Maguy; Department of Medicine, Division of Hematology, Centre Hospitalier Universitaire de Liège, University of Liège, 4000 Liège, Belgium
Misset, Benoît ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
CANIVET, Jean-Luc ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Beguin, Yves ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Baron, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Langue du document :
Anglais
Titre :
Overall Survival Rate in Allogeneic Stem Cell Transplanted Patients Requiring Intensive Care Can Be Predicted by the Prognostic Index for Critically Ill Allogeneic Transplantation Patients (PICAT) and the Sequential Organ Failure Assessment (SOFA) Scores.
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