Outcome of human umbilical cord blood stem cell transplantation (CBT) for acute myeloid leukemia in patients achieving first complete remission after one versus two induction courses: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).
Nagler, Arnon; Labopin, Myriam; Cornelissen, Jan Jet al.
2022 • In Bone Marrow Transplantation, 57 (10), p. 1514-1519
[en] We compared transplantation outcomes of adult patients with AML that underwent cord blood transplantation (CBT) in CR1 following 1 versus 2 induction courses. Study included 325 patients, 243 (75%) with 1 and 82 (25%) with 2 induction courses. Engraftment was lower for patients achieving CR1 after 1 vs. 2 induction courses: 91% vs. 99% (p = 0.02). Incidence of acute GVHD was similar, 38% and 36% (p = 0.81), as was 2-year chronic GVHD at 23.4% and 27.5%, respectively (p = 0.65). Two-year non-relapse mortality (NRM), relapse incidence (RI), leukemia-free survival (LFS), overall survival (OS) and GVHD-free, relapse-free survival (GRFS) were not statistically different between patients achieving CR1 with 1 vs. 2 induction courses with 23% vs. 24% (p = 0.87), 25% vs. 30% (p = 0.4), 52% vs. 46% (p = 0.3), 59% vs. 50% (p = 0.2), and 44% vs. 41% (p = 0.66), respectively. Results were confirmed by multivariable analysis, NRM (hazard ratio (HR) = 1.1; 95% CI, 0.6-1.8, p = 0.7), RI (HR = 1.4; 95% CI, 0.9-2.3, p = 0.1), LFS (HR = 1.3; 95% CI, 0.9-1.8, p = 0.2), OS (HR = 1.3; 95% CI, 0.9-1.9, p = 0.1), and GRFS (HR = 1.1; 95% CI, 0.8-1.5, p = 0.5). Overall, outcomes of AML patients undergoing CBT in CR1 achieved after 1 or 2 induction courses are similar.
Disciplines :
Hematology
Author, co-author :
Nagler, Arnon ; Division of Hematology, Sheba Medical Center, Tel Hashomer, Israel.
Labopin, Myriam; EBMT Paris study office, Department of Hematology, Saint Antoine Hospital, ; Sorbonne University, Department of Hematology, Saint Antoine Hospital, INSERM UMR
Cornelissen, Jan J; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of
Forcade, Edouard; CHU Bordeaux, Hôpital Haut-Leveque, Pessac, France.
Chevallier, Patrice; CHU Nantes Department, D'Hematologie, Nantes, France.
Fegueux, Nathalie; CHU Lapeyronie, Département d'Hématologie Clinique, Montpellier, France.
Sierra, Jorge; Hospital Santa Creu i Sant Pau Hematology Department, Barcelona, Spain.
Desmier, Deborah; Hopital La Miletrie, Head of the Bone Marrow Transplant Unit, Clinical
Labussière-Wallet, Hélène; Centre Hospitalier Lyon Sud, Pavillon Marcel Bérard, Service Hematologie, Lyon,
Byrne, Jenny L ; Nottingham University, Nottingham, UK.
Loschi, Michael ; Cote d'Azur University, Hematology department, Nice University Hospital, Nice
Blaise, Didier; Programme de Transplantation & Therapie Cellulaire, Centre de Recherche en
Baron, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Ruggeri, Annalisa; Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico
Mohty, Mohamad; Department of Hematology, Hospital Saint Antoine, EBMT Paris Study
Outcome of human umbilical cord blood stem cell transplantation (CBT) for acute myeloid leukemia in patients achieving first complete remission after one versus two induction courses: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).
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