Article (Scientific journals)
Outcome of human umbilical cord blood stem cell transplantation (CBT) for acute myeloid leukemia in patients achieving first complete remission after one versus two induction courses: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).
Nagler, Arnon; Labopin, Myriam; Cornelissen, Jan J et al.
2022In Bone Marrow Transplantation, 57 (10), p. 1514-1519
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Keywords :
Acute Disease; Adult; Bone Marrow; Cord Blood Stem Cell Transplantation/adverse effects; Graft vs Host Disease/etiology; Hematopoietic Stem Cell Transplantation/methods; Humans; Leukemia, Myeloid, Acute/complications; Recurrence; Remission Induction; Retrospective Studies; Transplantation Conditioning/methods
Abstract :
[en] We compared transplantation outcomes of adult patients with AML that underwent cord blood transplantation (CBT) in CR1 following 1 versus 2 induction courses. Study included 325 patients, 243 (75%) with 1 and 82 (25%) with 2 induction courses. Engraftment was lower for patients achieving CR1 after 1 vs. 2 induction courses: 91% vs. 99% (p = 0.02). Incidence of acute GVHD was similar, 38% and 36% (p = 0.81), as was 2-year chronic GVHD at 23.4% and 27.5%, respectively (p = 0.65). Two-year non-relapse mortality (NRM), relapse incidence (RI), leukemia-free survival (LFS), overall survival (OS) and GVHD-free, relapse-free survival (GRFS) were not statistically different between patients achieving CR1 with 1 vs. 2 induction courses with 23% vs. 24% (p = 0.87), 25% vs. 30% (p = 0.4), 52% vs. 46% (p = 0.3), 59% vs. 50% (p = 0.2), and 44% vs. 41% (p = 0.66), respectively. Results were confirmed by multivariable analysis, NRM (hazard ratio (HR) = 1.1; 95% CI, 0.6-1.8, p = 0.7), RI (HR = 1.4; 95% CI, 0.9-2.3, p = 0.1), LFS (HR = 1.3; 95% CI, 0.9-1.8, p = 0.2), OS (HR = 1.3; 95% CI, 0.9-1.9, p = 0.1), and GRFS (HR = 1.1; 95% CI, 0.8-1.5, p = 0.5). Overall, outcomes of AML patients undergoing CBT in CR1 achieved after 1 or 2 induction courses are similar.
Disciplines :
Hematology
Author, co-author :
Nagler, Arnon ;  Division of Hematology, Sheba Medical Center, Tel Hashomer, Israel.
Labopin, Myriam;  EBMT Paris study office, Department of Hematology, Saint Antoine Hospital,  ; Sorbonne University, Department of Hematology, Saint Antoine Hospital, INSERM UMR
Cornelissen, Jan J;  Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of
Forcade, Edouard;  CHU Bordeaux, Hôpital Haut-Leveque, Pessac, France.
Chevallier, Patrice;  CHU Nantes Department, D'Hematologie, Nantes, France.
Fegueux, Nathalie;  CHU Lapeyronie, Département d'Hématologie Clinique, Montpellier, France.
Sierra, Jorge;  Hospital Santa Creu i Sant Pau Hematology Department, Barcelona, Spain.
Desmier, Deborah;  Hopital La Miletrie, Head of the Bone Marrow Transplant Unit, Clinical
Labussière-Wallet, Hélène;  Centre Hospitalier Lyon Sud, Pavillon Marcel Bérard, Service Hematologie, Lyon,
Byrne, Jenny L ;  Nottingham University, Nottingham, UK.
Loschi, Michael ;  Cote d'Azur University, Hematology department, Nice University Hospital, Nice
Blaise, Didier;  Programme de Transplantation & Therapie Cellulaire, Centre de Recherche en
Baron, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Ruggeri, Annalisa;  Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico
Mohty, Mohamad;  Department of Hematology, Hospital Saint Antoine, EBMT Paris Study
More authors (5 more) Less
Language :
English
Title :
Outcome of human umbilical cord blood stem cell transplantation (CBT) for acute myeloid leukemia in patients achieving first complete remission after one versus two induction courses: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).
Publication date :
October 2022
Journal title :
Bone Marrow Transplantation
ISSN :
0268-3369
eISSN :
1476-5365
Volume :
57
Issue :
10
Pages :
1514-1519
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
Available on ORBi :
since 29 December 2022

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