Insomnia disorder (ID) is the second most common neuropsychiatric disorder. Its socioeconomic burden is enormous while diagnosis and treatment are difficult. A novel approach that reveals associations between insomnia genetic propensity and sleep phenotypes in youth may help understand the core of the disease isolated from comorbidities and pave the way for new treatments. We obtained quantitative nocturnal sleep electroencephalogram (EEG) features in 456 participants (18-31y, 49 women). Sleep EEG was recorded during a baseline night following at least 7 days of regular sleep times. We then assessed daytime sleep onset latency in a subsample of N = 359 men exposed to manipulations affecting sleep pressure. We sampled saliva or blood for polygenic risk score (PRS) determination. The PRS for ID was computed based on genome-wide common single nucleotide polymorphism assessments. Participants also completed a battery of behavioral and cognitive tests. The analyses revealed that the PRS for ID was negatively associated with cumulated EEG power in the delta (0.5-4 Hz) and theta (4-8 Hz) bands across rapid eye movement (REM) and non-REM sleep (p ≤ .0026; β ≥ -0.13) controlling for age, sex and BMI. The PRS for ID was also negatively associated with daytime likelihood of falling asleep (β = -0.19, p = .0009). Other explorations for associations with non-baseline-nights, cognitive measures, and mood did not yield significant results. These results propose that the need or the ability to fall asleep and to generate slow brain activity during sleep may constitute the core sleep-related risk factors for developing ID.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Koshmanova, Ekaterina ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Muto, Vincenzo ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Chylinski, Daphné ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Physiology of Cognition
MOURAUX, Charlotte ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Sleep and Chronobiology Lab, GIGA-Cyclotron Research Centre-In Vivo Imaging,
Degueldre, Christian ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences)
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Georges, Michel ; Université de Liège - ULiège > GIGA > GIGA Innovation
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie
Maquet, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Van Someren, Eus; Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Vandewalle, Gilles ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. 5th ed., 2013, American Psychiatric Publishing, Washington, DC, 10.1176/appi.books.9780890425596.
Anothaisintawee, T., Reutrakul, S., Van Cauter, E., Thakkinstian, A., Sleep disturbances compared to traditional risk factors for diabetes development: systematic review and meta-analysis. Sleep Med. Rev., 2016, 10.1016/j.smrv.2015.10.002.
Barclay, N.L., Kocevska, D., Bramer, W.M., Van Someren, E.J.W., Gehrman, P., The heritability of insomnia: a meta-analysis of twin studies. Genes Brain Behav., 20, 2021, 10.1111/gbb.12717.
Beck, Aaron T., Brown, G., Epstein, N., Steer, R.A., An inventory for measuring clinical anxiety: psychometric properties. J. Consult. Clin. Psychol. 56 (1988), 893–897, 10.1037/0022-006X.56.6.893.
Beck, A.T., Steer, R.A., M, G., Psychometric properties of the Beck depression inventory: twenty-five years of evaluation. Clin. Psychol. Rev. 8 (1988), 77–100, 10.1016/0272-7358(88)90050-5.
Benjamins, J.S., Migliorati, F., Dekker, K., Wassing, R., Moens, S., Blanken, T.F., te Lindert, B.H.W., Sjauw Mook, J., Van Someren, E.J.W., Insomnia heterogeneity: characteristics to consider for data-driven multivariate subtyping. Sleep Med. Rev., 2017, 10.1016/j.smrv.2016.10.005.
Benz, F., Riemann, D., Feige, B., Dreaming and insomnia: link between physiological REM parameters and mentation characteristics. Brain Sci. 10 (2020), 1–14, 10.3390/brainsci10060378.
Berthomier, C., Drouot, X., Herman-Stoïca, M., Berthomier, P., Prado, J., Bokar-Thire, D., Benoit, O., Mattout, J., D'Ortho, M.P., Automatic analysis of single-channel sleep EEG: validation in healthy individuals. Sleep 30 (2007), 1587–1595, 10.1093/sleep/30.11.1587.
Buysse, D.J., Reynolds, C.F., Monk, T.H., Berman, S.R., Kupfer, D.J., The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 28 (1989), 193–213, 10.1016/0165-1781(89)90047-4.
Cajochen, C., Foy, R., Dijk, D.J., Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans. Sleep Res. Online, 1999, 265–269.
Chandler, H.L., Wise, R.G., Murphy, K., Tansey, K.E., Linden, D.E.J., Lancaster, T.M., Polygenic impact of common genetic risk loci for Alzheimer's disease on cerebral blood flow in young individuals. Sci. Rep., 9, 2019, 10.1038/S41598-018-36820-3.
Coors, A., Imtiaz, M.A., Boenniger, M.M., Aziz, N.A., Ettinger, U., Breteler, M.M.B., Associations of genetic liability for Alzheimer's disease with cognition and eye movements in a large, population-based cohort study. Transl. Psychiatry, 12, 2022, 10.1038/S41398-022-02093-8.
Dudbridge, F., Power and predictive accuracy of polygenic risk scores. PLoS Genet., 9, 2013, 10.1371/journal.pgen.1003348.
Escott-Price, V., Sims, R., Bannister, C., Harold, D., Vronskaya, M., Majounie, E., Badarinarayan, N., Morgan, K., Passmore, P., Holmes, C., Powell, J., Brayne, C., Gill, M., Mead, S., Goate, A., Cruchaga, C., Lambert, J.C., Van Duijn, C., Maier, W., Ramirez, A., Holmans, P., Jones, L., Hardy, J., Seshadri, S., Schellenberg, G.D., Amouyel, P., Williams, J., Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain 138 (2015), 3673–3684, 10.1093/brain/awv268.
Faul, F., Erdfelder, E., Lang, A.-G., Buchner, A., G * Power 3 : A flexible statistical power analysis program for the social, behavioral. Biomed. Sci. 39 (2007), 175–191.
Feige, B., Baglioni, C., Spiegelhalder, K., Hirscher, V., Nissen, C., Riemann, D., The microstructure of sleep in primary insomnia: an overview and extension. Int. J. Psychophysiol. 89 (2013), 171–180, 10.1016/j.ijpsycho.2013.04.002.
Fernandez-Mendoza, J., Vgontzas, A.N., Bixler, E.O., Singareddy, R., Shaffer, M.L., Calhoun, S.L., Karataraki, M., Vela-Bueno, A., Liao, D., Clinical and polysomnographic predictors of the natural history of poor sleep in the general population. Sleep 35 (2012), 689–697, 10.5665/sleep.1832.
Gaggioni, G., Ly, J.Q.M., Muto, V., Chellappa, S., Jaspar, M., Meyer, C., Delfosse, T., Vanvinckenroye, A., Dumont, R., Coppieters't Wallant, D., Berthomier, C., Narbutas, J., Van Egroo, M., Luxen, A., Salmon, E., Collette, F., Phillips, C., Schmidt, C., Vandewalle, G., Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition. Neurobiol. Aging 78 (2019), 52–63, 10.1016/J.NEUROBIOLAGING.2019.02.004.
Gangwisch, J.E., Malaspina, D., Posner, K., Babiss, L.A., Heymsfield, S.B., Turner, J.B., Zammit, G.K., Pickering, T.G., Insomnia and sleep duration as mediators of the relationship between depression and hypertension incidence. Am. J. Hypertens. 23 (2010), 62–69, 10.1038/ajh.2009.202.
Gazecki, S., Bottary, R., Moore, K., Lasko, N., Kopotiyenko, K., Pace-Schott, E., Power spectral density of REM theta sleep in primary insomnia compared to good sleepers. Sleep 41 (2018), A43–A44, 10.1093/sleep/zsy061.109.
Goldman-Mellor, S., Caspi, A., Gregory, A.M., Harrington, H., Poulton, R., Moffitt, T.E., Is insomnia associated with deficits in neuropsychological functioning? Evidence from a Population-Based Study. Sleep, 38, 2015, 623, 10.5665/sleep.4584.
González, M.M., Valatx, J.L., Debilly, G., Role of the locus coeruleus in the sleep rebound following two different sleep deprivation methods in the rat. Brain Res. 740 (1996), 215–226, 10.1016/S0006-8993(96)00871-2.
Gui, Y., Zhou, X., Wang, Zixin, Zhang, Y., Wang, Zhaobin, Zhou, G., Zhao, Y., Liu, M., Lu, H., Zhao, H., Sex-specific genetic association between psychiatric disorders and cognition, behavior and brain imaging in children and adults. Transl. Psychiatry, 12, 2022, 10.1038/S41398-022-02041-6.
Harvey, A.G., Tang, N.K.Y., (Mis)perception of sleep in insomnia: a puzzle and a resolution. Psychol. Bull. 138 (2012), 77–101, 10.1037/a0025730.
Jansen, P.R., Watanabe, K., Stringer, S., Skene, N., Bryois, J., Hammerschlag, A.R., de Leeuw, C.A., Benjamins, J.S., Muñoz-Manchado, A.B., Nagel, M., Savage, J.E., Tiemeier, H., White, T., Agee, M., Alipanahi, B., Auton, A., Bell, R.K., Bryc, K., Elson, S.L., Fontanillas, P., Furlotte, N.A., Hinds, D.A., Huber, K.E., Kleinman, A., Litterman, N.K., McCreight, J.C., McIntyre, M.H., Mountain, J.L., Noblin, E.S., Northover, C.A.M., Pitts, S.J., Sathirapongsasuti, J.F., Sazonova, O.V., Shelton, J.F., Shringarpure, S., Tian, C., Wilson, C.H., Tung, J.Y., Hinds, D.A., Vacic, V., Wang, X., Sullivan, P.F., van der Sluis, S., Polderman, T.J.C., Smit, A.B., Hjerling-Leffler, J., Van Someren, E.J.W., Posthuma, D., Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nat. Genet. 51 (2019), 394–403, 10.1038/s41588-018-0333-3.
Johns, M.W., A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14 (1991), 540–545, 10.1093/sleep/14.6.540.
Kessler, R.C., Berglund, P.A., Coulouvrat, C., Hajak, G., Roth, T., Shahly, V., Shillington, A.C., Stephenson, J.J., Walsh, J.K., Insomnia and the performance of US workers: results from the America insomnia survey. Sleep 34 (2011), 1161–1171, 10.5665/SLEEP.1230.
Ly, J.Q.M.M., Gaggioni, G., Chellappa, S.L., Papachilleos, S., Brzozowski, A., Borsu, C., Rosanova, M., Sarasso, S., Middleton, B., Luxen, A., Archer, S.N., Phillips, C., Dijk, D.-J.J.D.-J., Maquet, P., Massimini, M., Vandewalle, G., Circadian regulation of human cortical excitability. Nat. Commun., 7, 2016, 10.1038/ncomms11828.
Mascetti, L., Foret, A., Schrouff, J., Muto, V., Dideberg, V., Balteau, E., Degueldre, C., Phillips, C., Collette, F., Bours, V., Concurrent synaptic and systems memory consolidation during. Sleep 33 (2013), 10182–10190, 10.1523/JNEUROSCI.0284-13.2013.
Merica, H., Spectral characteristics of sleep EEG in chronic insomnia. Eur. J. Neurosci. 10 (1998), 1826–1834, 10.1046/j.1460-9568.1998.00189.x.
Muto, V., Jaspar, M., Meyer, C., Kussé, C., Chellappa, S.L., Degueldre, C., Balteau, E., Le Bourdiec, A.S., Luxen, A., Middleton, B., Archer, S.N., Phillips, C., Collette, F., Vandewalle, G., Dijk, D.J., Maquet, P., Local modulation of human brain responses by circadian rhythmicity and sleep debt. Science (80) 353 (2016), 687–690, 10.1126/science.aad2993.
Muto, V., Koshmanova, E., Ghaemmaghami, P., Jaspar, M., Meyer, C., Elansary, M., Van Egroo, M., Chylinski, D., Berthomier, C., Brandewinder, M., Mouraux, C., Schmidt, C., Hammad, G., Coppieters, W., Ahariz, N., Degueldre, C., Luxen, A., Salmon, E., Phillips, C., Archer, S.N., Yengo, L., Byrne, E., Collette, F., Georges, M., Dijk, D.-J., Maquet, P., Visscher, P.M., Vandewalle, G., Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness. Sleep, 44, 2021, 10.1093/sleep/zsaa137.
Ohayon, M.M., Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med. Rev., 2002, 10.1053/smrv.2002.0186.
Patel, D., Steinberg, J., Patel, P., Insomnia in the elderly: a review. J. Clin. Sleep Med., 2018, 10.5664/jcsm.7172.
Perlis, M.L., Smith, M.T., Andrews, P.J., Orff, H., Giles, D.E., Beta/gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls. Sleep 24 (2001), 110–117, 10.1093/sleep/24.1.110.
Perlis, M., Gehrman, P., Terzano, M., Cote, K., Riemann, D., Sleep EEG in patients with primary insomnia. Insomnia: Diagnosis and Treatment, 2010, CRC Press, 50–64, 10.3109/9781420080803.006.
Plante, D.T., Goldstein, M.R., Cook, J.D., Smith, R., Riedner, B.A., Rumble, M.E., Jelenchick, L., Roth, A., Tononi, G., Benca, R.M., Peterson, M.J., Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: a high density EEG investigation. Clin. Neurophysiol. 127 (2016), 1436–1444, 10.1016/j.clinph.2015.10.040.
Popa, D., Duvarci, S., Popescu, A.T., Léna, C., Paré, D., Coherent amygdalocortical theta promotes fear memory consolidation during paradoxical sleep. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 6516–6519, 10.1073/pnas.0913016107.
Privé, F., Vilhjálmsson, B.J., Aschard, H., Blum, M.G.B., Making the most of clumping and thresholding for polygenic scores. Am. J. Hum. Genet. 105 (2019), 1213–1221, 10.1016/j.ajhg.2019.11.001.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A.R., Bender, D., Maller, J., Sklar, P., de Bakker, P.I.W., Daly, M.J., Sham, P.C., PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81 (2007), 559–575, 10.1086/519795.
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., Nissen, C., The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med. Rev., 2010, 10.1016/j.smrv.2009.04.002.
Riemann, D., Spiegelhalder, K., Nissen, C., Hirscher, V., Baglioni, C., Feige, B., REM sleep instability - a new pathway for insomnia?. Pharmacopsychiatry., 2012, 10.1055/s-0031-1299721.
Robbins, R., Weaver, M.D., Barger, L.K., Wang, W., Quan, S.F., Czeisler, C.A., Sleep difficulties, incident dementia and all-cause mortality among older adults across 8 years: findings from the National Health and Aging Trends Study. J. Sleep Res., 00, 2021, 13395, 10.1111/jsr.13395.
Rosinvil, T., Bouvier, J., Dubé, J., Lafrenière, A., Bouchard, M., Cyr-Cronier, J., Gosselin, N., Carrier, J., Lina, J.M., Are age and sex effects on sleep slow waves only a matter of electroencephalogram amplitude?. Sleep 44 (2021), 1–12, 10.1093/sleep/zsaa186.
Spielman, A.J., Caruso, L.S., Glovinsky, P.B., A behavioral perpective on insomnia treatment. Psychiatr. Clin. North Am. 10 (1987), 541–553, 10.1016/s0193-953x(18)30532-x.
Swift, K.M., Gross, B.A., Frazer, M.A., Bauer, D.S., Clark, K.J.D., Vazey, E.M., Aston-Jones, G., Li, Y., Pickering, A.E., Sara, S.J., Poe, G.R., Abnormal locus coeruleus sleep activity alters sleep signatures of memory consolidation and impairs place cell stability and spatial memory. Curr. Biol. 28 (2018), 3599–3609.e4, 10.1016/j.cub.2018.09.054.
Vandewalle, G., Archer, S., Wuillaume, C., Balteau, E., Degueldre, C., Luxen, A., Maquet, P., Dijk, D., Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype. J. Neurosci. 29 (2009), 7948–7956, 10.1523/JNEUROSCI.0229-09.2009.
Vilhjalmsson, B.J., Yang, J., Finucane, H.K., Gusev, A., Lindström, S., Ripke, S., Genovese, G., Loh, P.R., Bhatia, G., Do, R., Hayeck, T., Won, H.H., Neale, B.M., Corvin, A., Walters, J.T.R., Farh, K.H., Holmans, P.A., Lee, P., Bulik-Sullivan, B., Collier, D.A., Huang, H., Pers, T.H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S.A., Begemann, M., Belliveau, R.A., Bene, J., Bergen, S.E., Bevilacqua, E., Bigdeli, T.B., Black, D.W., Bruggeman, R., Buccola, N.G., Buckner, R.L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R.M., Carr, V.J., Carrera, N., Catts, S.V., Chambert, K.D., Chan, R.C.K., Chen, R.Y.L., Chen, E.Y.H., Cheng, W., Cheung, E.F.C., Chong, S.A., Cloninger, C.R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J.J., Curtis, D., Davidson, M., Davis, K.L., Degenhardt, F., Del Favero, J., Delisi, L.E., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A.H., Farrell, M.S., Frank, J., Franke, L., Freedman, R., Freimer, N.B., Friedl, M., Friedman, J.I., Fromer, M., Georgieva, L., Gershon, E.S., Giegling, I., Giusti-Rodrguez, P., Godard, S., Goldstein, J.I., Golimbet, V., Gopal, S., Gratten, J., Grove, J., De Haan, L., Hammer, C., Hamshere, M.L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A.M., Henskens, F.A., Herms, S., Hirschhorn, J.N., Hoffmann, P., Hofman, A., Hollegaard, M.V., Hougaard, D.M., Ikeda, M., Joa, I., Julia, A., Kahn, R.S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M.C., Kelly, B.J., Kennedy, J.L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J.A., Konte, B., Kucinskas, V., Kucinskiene, Z.A., Kuzelova-Ptackova, H., Kahler, A.K., Laurent, C., Keong, J.L.C., Lee, S.H., Legge, S.E., Lerer, B., Li, M., Li, T., Liang, K.Y., Lieberman, J., Limborska, S., Loughland, C.M., Lubinski, J., Lnnqvist, J., Macek, M., Magnusson, P.K.E., Maher, B.S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R.W., McDonald, C., McIntosh, A.M., Meier, S., Meijer, C.J., Melegh, B., Melle, I., Mesholam-Gately, R.I., Metspalu, A., Michie, P.T., Milani, L., Milanova, V., Mokrab, Y., Morris, D.W., Mors, O., Mortensen, P.B., Murphy, K.C., Murray, R.M., Myin-Germeys, I., Mller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D.A., Nestadt, G., Nicodemus, K.K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., O'Neill, F.A., Oh, S.Y., Olincy, A., Olsen, L., Van Os, J., Pantelis, C., Papadimitriou, G.N., Papiol, S., Parkhomenko, E., Pato, M.T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D.O., Pietilinen, O., Pimm, J., Pocklington, A.J., Powell, J., Price, A., Pulver, A.E., Purcell, S.M., Quested, D., Rasmussen, H.B., Reichenberg, A., Reimers, M.A., Richards, A.L., Roffman, J.L., Roussos, P., Ruderfer, D.M., Salomaa, V., Sanders, A.R., Schall, U., Schubert, C.R., Schulze, T.G., Schwab, S.G., Scolnick, E.M., Scott, R.J., Seidman, L.J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J.M., Sim, K., Slominsky, P., Smoller, J.W., So, H.C., Spencer, C.C.A., Stahl, E.A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R.E., Strengman, E., Strohmaier, J., Stroup, T.S., Subramaniam, M., Suvisaari, J., Svrakic, D.M., Szatkiewicz, J.P., Sderman, E., Thirumalai, S., Toncheva, D., Tooney, P.A., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B.T., Weiser, M., Wildenauer, D.B., Williams, N.M., Williams, S., Witt, S.H., Wolen, A.R., Wong, E.H.M., Wormley, B.K., Wu, J.Q., Xi, H.S., Zai, C.C., Zheng, X., Zimprich, F., Wray, N.R., Stefansson, K., Adolfsson, R., Andreassen, O.A., Visscher, P.M., Blackwood, D.H.R., Bramon, E., Buxbaum, J.D., Børglum, A.D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P.V., Gill, M., Gurling, H., Hultman, C.M., Iwata, N., Jablensky, A.V., Jonsson, E.G., Kendler, K.S., Kirov, G., Knight, J., Lencz, T., Levinson, D.F., Li, Q.S., Liu, J., Malhotra, A.K., McCarroll, S.A., McQuillin, A., Moran, J.L., Mowry, B.J., Nthen, M.M., Ophoff, R.A., Owen, M.J., Palotie, A., Pato, C.N., Petryshen, T.L., Posthuma, D., Rietschel, M., Riley, B.P., Rujescu, D., Sham, P.C., Sklar, P., St. Clair, D., Weinberger, D.R., Wendland, J.R., Werge, T., Daly, M.J., Sullivan, P.F., O'Donovan, M.C., Kraft, P., Hunter, D.J., Adank, M., Ahsan, H., Aittomäki, K., Baglietto, L., Berndt, S., Blomquist, C., Canzian, F., Chang-Claude, J., Chanock, S.J., Crisponi, L., Czene, K., Dahmen, N., Dos Santos Silva, I., Easton, D., Eliassen, A.H., Figueroa, J., Fletcher, O., Garcia-Closas, M., Gaudet, M.M., Gibson, L., Haiman, C.A., Hall, P., Hazra, A., Hein, R., Henderson, B.E., Hopper, J.L., Irwanto, A., Johansson, M., Kaaks, R., Kibriya, M.G., Lichtner, P., Lund, E., Makalic, E., Meindl, A., Meijers-Heijboer, H., Müller-Myhsok, B., Muranen, T.A., Nevanlinna, H., Peeters, P.H., Peto, J., Prentice, R.L., Rahman, N., Sánchez, M.J., Schmidt, D.F., Schmutzler, R.K., Southey, M.C., Tamimi, R., Travis, R., Turnbull, C., Uitterlinden, A.G., Van Der Luijt, R.B., Waisfisz, Q., Wang, Z., Whittemore, A.S., Yang, R., Zheng, W., Kathiresan, S., Pato, M., Pato, C., Stahl, E., Zaitlen, N., Pasaniuc, B., Kenny, E.E., Schierup, M.H., De Jager, P., Patsopoulos, N.A., McCarroll, S., Daly, M., Purcell, S., Chasman, D., Neale, B., Goddard, M., Patterson, N., Price, A.L., Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am. J. Hum. Genet. 97 (2015), 576–592, 10.1016/J.AJHG.2015.09.001.
Wallant, D.C., et al. Automatic artifacts and arousals detection in whole-night sleep EEG recordings. J. Neurosci. Methods 258 (2016), 2124–2133, 10.1016/j.jneumeth.2015.11.005.
Wassing, R., Lakbila-Kamal, O., Ramautar, J.R., Stoffers, D., Schalkwijk, F., Van Someren, E.J.W., Restless REM sleep impedes overnight amygdala adaptation. Curr. Biol. 29 (2019), 2351–2358.e4.
Wassing, R., Schalkwijk, F., Lakbila-Kamal, O., Ramautar, J.R., Stoffers, D., Mutsaerts, H.J.M.M., Talamini, L.M., Van Someren, E.J.W., Haunted by the past: old emotions remain salient in insomnia disorder. Brain 142 (2019), 1783–1796, 10.1093/brain/awz089.
Watanabe, K., Jansen, P.R., Savage, J.E., Nandakumar, P., Wang, X., Agee, M., Aslibekyan, S., Auton, A., Bell, R.K., Bryc, K., Clark, S.K., Elson, S.L., Fletez-Brant, K., Fontanillas, P., Furlotte, N.A., Gandhi, P.M., Heilbron, K., Hicks, B., Huber, K.E., Jewett, E.M., Jiang, Y., Kleinman, A., Lin, K.H., Litterman, N.K., McCreight, J.C., McIntyre, M.H., McManus, K.F., Mountain, J.L., Mozaffari, S.V., Noblin, E.S., Northover, C.A.M., O'Connell, J., Pitts, S.J., Poznik, G.D., Sathirapongsasuti, J.F., Shelton, J.F., Shi, J., Shringarpure, S., Tian, C., Tung, J.Y., Tunney, R.J., Vacic, V., Wang, W., Hinds, D.A., Gelernter, J., Levey, D.F., Polimanti, R., Stein, M.B., Van Someren, E.J.W., Smit, A.B., Posthuma, D., Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nat. Genet. 548:54 (2022), 1125–1132, 10.1038/s41588-022-01124-w.
Wittchen, H.U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jönsson, B., Olesen, J., Allgulander, C., Alonso, J., Faravelli, C., Fratiglioni, L., Jennum, P., Lieb, R., Maercker, A., van Os, J., Preisig, M., Salvador-Carulla, L., Simon, R., Steinhausen, H.C., The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 21 (2011), 655–679, 10.1016/j.euroneuro.2011.07.018.
Yengo, L., Sidorenko, J., Kemper, K.E., Zheng, Z., Wood, A.R., Weedon, M.N., Frayling, T.M., Hirschhorn, J., Yang, J., Visscher, P.M., Meta-analysis of genome-wide association studies for height and body mass index in ∼700 000 individuals of European ancestry. Hum. Mol. Genet. 27 (2018), 3641–3649, 10.1093/hmg/ddy271.
Zhao, W., Zhang, Q., Su, Y., Chen, X., Li, X., Du, B., Deng, X., Ji, F., Li, Jin, Dong, Q., Chen, C., Jun, Li, Effect of schizophrenia risk gene polymorphisms on cognitive and neural plasticity. Schizophr. Res. 248 (2022), 173–179, 10.1016/J.SCHRES.2022.08.014.
Zheng, H., Sun, J., Pang, T., Liu, J., Lu, L., Chang, S., Identify novel, shared and disorder-specific genetic architecture of major depressive disorder, insomnia and chronic pain. J. Psychiatr. Res. 155 (2022), 511–517, 10.1016/J.JPSYCHIRES.2022.09.036.
