Article (Scientific journals)
Progressive fibrosing interstitial lung disease in rheumatoid arthritis: A retrospective study
DENIS, Anna; Henket, Monique; Ernst, Marie et al.
2022In Frontiers in Medicine, 9
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Keywords :
General Medicine
Abstract :
[en] Background and objectiveRheumatoid arthritis associated-interstitial lung disease (RA-ILD) is the most common pulmonary manifestation of rheumatoid arthritis (RA) and an important cause of mortality. In patients suffering from interstitial lung diseases (ILD) from different etiologies (including RA-ILD), a significant proportion is exhibiting a fibrotic progression despite immunosuppressive therapies, defined as progressive fibrosing interstitial lung disease (PF-ILD). Here, we report the frequency of RA-ILD and PF-ILD in all RA patients’ cohort at University Hospital of Liège and compare their characteristics and outcomes.MethodsPatients were retrospectively recruited from 2010 to 2020. PF-ILD was defined based on functional, clinical and/or iconographic progression criteria within 24 months despite specific anti-RA treatment.ResultsOut of 1,500 RA patients, about one third had high-resolution computed tomography (HRCT) performed, 89 showed RA-ILD and 48 PF-ILD. RA-ILD patients were significantly older than other RA patients (71 old of median age vs. 65, p < 0.0001), with a greater proportion of men (46.1 vs. 27.7%, p < 0.0001) and of smoking history. Non-specific interstitial pneumonia pattern was more frequent than usual interstitial pneumonia among RA-ILD (60.7 vs. 27.0%) and PF-ILD groups (60.4 vs. 31.2%). The risk of death was 2 times higher in RA-ILD patients [hazard ratio 2.03 (95% confidence interval 1.15–3.57), p < 0.01] compared to RA.ConclusionWe identified a prevalence of PF-ILD of 3% in a general RA population. The PF-ILD cohort did not seem to be different in terms of demographic characteristics and mortality compared to RA-ILD patients who did not exhibit the progressive phenotype yet.
Disciplines :
Cardiovascular & respiratory systems
Rheumatology
Author, co-author :
DENIS, Anna ;  Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants
Henket, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Ernst, Marie  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Maes, Nathalie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
THYS, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Regnier, Céline ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Malaise, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Frix, Anne-Noëlle ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
GESTER, Fanny ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
DESIR, Colin ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Meunier, Paul ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Malaise, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
More authors (4 more) Less
Language :
English
Title :
Progressive fibrosing interstitial lung disease in rheumatoid arthritis: A retrospective study
Publication date :
30 November 2022
Journal title :
Frontiers in Medicine
eISSN :
2296-858X
Publisher :
Frontiers Media SA
Volume :
9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 December 2022

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