Article (Scientific journals)
Penicillium digitatum as a Model Fungus for Detecting Antifungal Activity of Botanicals: An Evaluation on Vietnamese Medicinal Plant Extracts.
Tran My Hanh; Le, Diep Hong; Nguyen, Van-Anh Thi et al.
2022In Journal of Fungi, 8 (9), p. 956
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Keywords :
Mahonia bealei; Penicillium digitatum; Vietnamese medicinal plants; antifungal activity; berberine; fungal pathogens; Ecology, Evolution, Behavior and Systematics; Plant Science; Microbiology (medical)
Abstract :
[en] Medicinal plants play important roles in traditional medicine, and numerous compounds among them have been recognized for their antimicrobial activity. However, little is known about the potential of Vietnamese medicinal plants for antifungal activity. In this study, we examined the antagonistic activity of twelve medicinal plant species collected in Northern Vietnam against Penicillium digitatum, Aspergillus flavus, Aspergillus fumigatus, and Candida albicans. The results showed that the antifungal activities of the crude extracts from Mahonia bealei, Ficus semicordata, and Gnetum montanum were clearly detected with the citrus postharvest pathogen P. digitatum. These extracts could fully inhibit the growth of P. digitatum on the agar medium, and on the infected citrus fruits at concentrations of 300-1000 µg/mL. Meanwhile, the other tested fungi were less sensitive to the antagonistic activity of the plant extracts. In particular, we found that the ethanolic extract of M. bealei displayed a broad-spectrum antifungal activity against all four pathogenic fungi. Analysis of this crude extract by enrichment coupled with high-performance liquid chromatography revealed that berberine and palmatine are major metabolites. Additional inspections indicated berberine as the key compound responsible for the antifungal activity of the M. bealei ethanolic extract. Our study provides a better understanding of the potential of Vietnamese medicinal plant resources for combating fungal pathogens. This work also highlights that the citrus pathogen P. digitatum can be employed as a model fungus for screening the antifungal activity of botanicals.
Research center :
GIGA I3-Laboratory for Organogenesis and Regeneration -ULiège
Disciplines :
Microbiology
Pharmacy, pharmacology & toxicology
Author, co-author :
Tran My Hanh ;  Université de Liège - ULiège > Faculté des Sciences > Form. doct. sc. (bioch., biol. mol. cel., bioinf. - paysage) ; Université de Liège - ULiège > Faculté des Sciences > Doct. sc. (bioch., biol. mol. cel., bioinf. - paysage) ; ULiège - Université de Liège [BE] > Sciences de la Vie > Lab. Organogenèse et Régénération, GIGA-I3
Le, Diep Hong;  Faculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam
Nguyen, Van-Anh Thi ;  Faculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam
Vu, Tao Xuan;  Center for Experimental Biology, National Center for Technological Progress, Ministry of Science and Technology, C6 Thanh Xuan Bac, Thanh Xuan, Hanoi 100000, Vietnam
Thanh, Nguyen Thi Kim;  Faculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam
Giang, Do Hoang;  Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam
Dat, Nguyen Tien;  Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam
Pham, Hai The;  Faculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam
Muller, Marc  ;  Université de Liège - ULiège > GIGA > GIGA I3 - Laboratory for Organogenesis and Regeneration
Nguyen, Huy Quang;  Faculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam ; National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam
Tran, Van-Tuan ;  Faculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam ; National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi 100000, Vietnam
Language :
English
Title :
Penicillium digitatum as a Model Fungus for Detecting Antifungal Activity of Botanicals: An Evaluation on Vietnamese Medicinal Plant Extracts.
Publication date :
13 September 2022
Journal title :
Journal of Fungi
eISSN :
2309-608X
Publisher :
MDPI, Switzerland
Volume :
8
Issue :
9
Pages :
956
Peer reviewed :
Peer reviewed
Funding text :
This research was funded by ARES (Académie de Recherche et d’Enseignement Supérieur) through the project “Exploring the Medical and (Eco)-toxicological Potential of Natural Extracts in North Vietnam”.
Available on ORBi :
since 08 October 2022

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