[en] Understanding osteoblast differentiation and their function in bone matrix deposition and mineralization is central to the comprehension of bone development and of various bone pathologies. It is, therefore, crucial to not only follow the expression of some landmark transcription factors or ECM proteins but to also investigate the status of signaling pathways and factors regulating these processes. This can only be achieved by
assessing the entire transcriptome of these cells. The aim is to study the osteoblast
transcriptome, focusing on the possible existence of specific subpopulations at 4dpf and to investigate the role of the fbln1 and col10a1a genes that encode bone ECM proteins in
zebrafish skeletal development indicated in the osteoblast transcriptomic data.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Raman, Ratish ; Université de Liège - ULiège > GIGA > GIGA I3 - Laboratory for Organogenesis and Regeneration
Zappia, Jérémie ; Université de Liège - ULiège > Département des sciences de la motricité > musculoSkeletal Innovative research Lab (mSKIL)
Nivelle, Renaud ; Université de Liège - ULiège > GIGA > GIGA I3 - Laboratory for Organogenesis and Regeneration
Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Lavergne, Arnaud ; Université de Liège - ULiège > Département de gestion vétérinaire des Ressources Animales (DRA) > Génomique animale
Caetano da Silva Caroline; INSERM U1132 Bioscar and Universite de Paris Cite > Reference Centre for Rare Bone Diseases, Hospital Lariboisiere, F-75010, Paris, France
Degueldre Christian; University of Liege, GIGA CRC In Vivo Imaging, GIGA Platform, Sart Tilman Campus, 4000 Liege, Belgium
Ostertag Agnes; INSERM U1132 Bioscar and Universite de Paris-Cite, > Reference Centre for Rare Bone Diseases, Hospital Lariboisiere, F-75010, Paris, France
Renn, Jörg ; ULiège - University of Liège [BE] > Laboratory of Organogenesis and Regeneration
Collet Corrine; INSERM U1132 Bioscar and Universite de Paris-Cite, > Reference Centre for Rare Bone Diseases, Hospital Lariboisiere, F-75010, Paris, France
Plenevaux, Alain ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Preclinical Imaging
Solal Cohen Martine; INSERM U1132 Bioscar and Universite de Paris Cite, > Reference Centre for Rare Bone Diseases, Hospital Lariboisiere, F-75010, Paris, France
Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > musculoSkeletal Innovative research Lab (mSKIL)
Muller, Marc ; Université de Liège - ULiège > GIGA > GIGA I3 - Laboratory for Organogenesis and Regeneration
Zebrafish Osteoblast Transcriptome reveals genes that encode bone extra cellular matrix proteins which on mutating affect bone development
Publication date :
07 September 2022
Event name :
Deutsche Gesellschaft for Martrixbiologie e.V. 2022 (DGMB 2022)
Event organizer :
Frank Zaucke, Uniklinikum Frankfurt am Main, Germany
Event place :
Frankfurt am Main, Germany
Event date :
07/09/2022
Audience :
International
Peer reviewed :
Peer reviewed
European Projects :
H2020 - 766347 - BioMedaqu - Aquaculture meets Biomedicine: Innovation in Skeletal Health research.
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique Fondation Arthrose EU - European Union
Funding number :
ETN 766347
Funding text :
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 766347; ); Fondation Arthrose "Jean Henrotin Prize"
