Fused deposition modeling 3D printing of solid oral dosage forms containing amorphous solid dispersions: How to elucidate drug dissolution mechanisms through surface spectral analysis techniques?

Parulski, Chloé; Gresse, Eva; Jennotte, Olivier; Felten, Alexandre; Ziemons, Eric; Lechanteur, Anna; Evrard, Brigitte

doi:10.1016/j.ijpharm.2022.122157

Article (Scientific journals)

Fused deposition modeling 3D printing of solid oral dosage forms containing amorphous solid dispersions: How to elucidate drug dissolution mechanisms through surface spectral analysis techniques?

Parulski, Chloé; Gresse, Eva; Jennotte, Olivier et al.

2022 • In International Journal of Pharmaceutics, 626, p. 122157

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/294571

DOI
10.1016/j.ijpharm.2022.122157

PubMed
36055443

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Keywords :

3D printing; Additive manufacturing; Amorphous solid dispersion; Fused deposition modeling; Hot-melt extrusion; Itraconazole; Pharmaceutical Science

Abstract :

[en] Many active principles belong to the second class of the Biopharmaceutics Classification System due to their low aqueous solubility. Elaboration of new solid oral forms by hot-melt extrusion and fused deposition modeling appears as a promising tool to increase the dissolution rate of these drugs. Indeed, hot-melt extrusion allows the amorphisation of drugs and forms with complex geometries are built by 3D printing. Therefore, the goal of this work is to enhance the dissolution rate of poorly soluble drugs using hot-melt extrusion coupled with fused deposition modeling. Four formulations containing Affinisol® 15LV, Kollidon® VA64 and a challenging amount of itraconazole (25 % (wt.)) were successfully printed into forms of 20, 50 and 80 % infill densities. Differential scanning calorimetry analysis has shown that itraconazole remained amorphous during 52 weeks. The drug release rate was highly improved compared to itraconazole in a crystalline form. The dissolution rate was influenced by the infill density and the polymer composition of printed forms which could modify respectively the surface to volume ratio and the distribution of the components in the printed forms. One formulation printed with 20 % infill density even had a solubility profile similar to that of Sporanox®, the commercialized drug product in Belgium.

Research Center/Unit :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Parulski, Chloé ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Gresse, Eva ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Jennotte, Olivier ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Felten, Alexandre; Synthesis, Irradiation and Analysis of Materials (SIAM) Platform, University of Namur, Rue de Bruxelles 61, 5000 Namur, Belgium

Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Lechanteur, Anna ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Language :

English

Title :

Fused deposition modeling 3D printing of solid oral dosage forms containing amorphous solid dispersions: How to elucidate drug dissolution mechanisms through surface spectral analysis techniques?

Alternative titles :

[fr] Impression 3D à modélisation par dépôt fondu de formes galéniques orales solides contenant des dispersions solides amorphes: Comment élucider les mécanismes de dissolution du principe actif par des techniques d'analyse spectrale de surface?

Original title :

[en] Fused deposition modeling 3D printing of solid oral dosage forms containing amorphous solid dispersions: How to elucidate drug dissolution mechanisms through surface spectral analysis techniques?

Publication date :

31 August 2022

Journal title :

International Journal of Pharmaceutics

ISSN :

0378-5173

eISSN :

1873-3476

Publisher :

Elsevier, Netherlands

Volume :

626

Pages :

122157

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0378517322007116?httpAccept=text/xml

Funders :

FEDER - Fonds Européen de Développement Régional

Funding number :

884148- 329407

Available on ORBi :

since 13 September 2022

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