Article (Scientific journals)
Strontium ranelate: new data on fracture prevention and mechanisms of action.
Reginster, Jean-Yves; Deroisy, Rita; NEUPREZ, Audrey et al.
2009In Current Osteoporosis Reports, 7 (3), p. 96-102
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Abstract :
[en] Osteoporosis treatments need to combine an unequivocally demonstrated reduction of fractures, at various skeletal sites, long-term safety, and a user-friendly profile that optimizes therapeutic adherence. Strontium ranelate is the first compound to simultaneously decrease bone resorption and stimulate bone formation. Its anti-fracture efficacy at various skeletal sites has been established for as long as 5 years through studies of the highest methodological standards. Increases in bone mineral density observed after 1 year of treatment are predictive of the long-term fracture efficacy, suggesting for the first time in osteoporosis that bone densitometry can be used as a monitoring tool. Due to a positive risk/benefit ratio, strontium ranelate is now considered as a first-line treatment in the management of osteoporosis.
Disciplines :
General & internal medicine
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Deroisy, Rita  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
NEUPREZ, Audrey ;  Université de Liège - ULiège > Département des Sciences de la Santé Publique > Epidémiologie et Santé Publique
Hiligsmann, Mickaël ;  Université de Liège - ULiège > HEC-Ecole de gestion : UER > Economie industrielle
Zegels, Brigitte ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Language :
English
Title :
Strontium ranelate: new data on fracture prevention and mechanisms of action.
Publication date :
2009
Journal title :
Current Osteoporosis Reports
ISSN :
1544-1873
eISSN :
1544-2241
Publisher :
Current Science, United States
Volume :
7
Issue :
3
Pages :
96-102
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 November 2009

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