Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context.

Cortet, Bernard; Dennison, Elaine; Diez-Perez, Adolfo; Locquet, Médéa; Muratore, Maurizio; Nogués, Xavier; Ovejero Crespo, Diana; Quarta, Eugenio; Brandi, Maria Luisa

doi:10.1016/j.bone.2020.115786

Article (Scientific journals)

Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context.

Cortet, Bernard; Dennison, Elaine; Diez-Perez, Adolfo et al.

2021 • In BONE, 143, p. 115786

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/294124

DOI
10.1016/j.bone.2020.115786

PubMed
33278653

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Keywords :

Dual-energy X-ray Absorptiometry (DXA); European multicentre study; Femoral neck; Lumbar spine; Osteoporosis diagnosis; Radiofrequency Echographic Multi Spectrometry (REMS); Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Female; Femur Neck/diagnostic imaging; Humans; Lumbar Vertebrae/diagnostic imaging; Middle Aged; ROC Curve; Spectrum Analysis; Ultrasonography; Bone Density; Osteoporosis/diagnostic imaging; Femur Neck; Lumbar Vertebrae; Osteoporosis; Endocrinology, Diabetes and Metabolism; Physiology; Histology

Abstract :

[en] BACKGROUND: Radiofrequency Echographic Multi Spectrometry (REMS) is a non-ionizing technology for the densitometric assessment of osteoporosis. It has already been validated in Italian women with respect to the current clinical reference technology, Dual-energy X-ray Absorptiometry (DXA). PURPOSE: Aim of the current study was to assess the diagnostic accuracy of REMS technology with respect to DXA in a wider European clinical context. METHODS: A total of 4307 female Caucasian patients aged between 30 and 90 years underwent DXA and REMS scans at femoral neck and/or lumbar spine (the site depending on the medical prescription). The acquired data underwent a rigorous quality check in order to exclude the erroneous DXA and REMS reports. The diagnostic agreement between the two technologies was assessed, also stratifying for patients' age groups. The ability to recognise previously fractured patients was also investigated. RESULTS: Overall, 4245 lumbar spine scans and 4271 femoral neck scans were performed. The ability to discriminate patients with and without osteoporosis by femoral neck investigation resulted in sensitivity and specificity of 90.4% and 95.5%, respectively. For lumbar spine scans, a sensitivity of 90.9% and a specificity of 95.1% were obtained. The areas under the curve (AUCs) of the Receiver Operating Characteristic (ROC) curve evaluating the ability to discriminate groups of patients with previous osteoporotic fracture using DXA and REMS T-score values were 0.631 and 0.683 (p < 0.0001), respectively, for femoral neck scans, whereas 0.603 and 0.640 (p = 0.0002), respectively, for lumbar spine scans. CONCLUSION: The diagnostic effectiveness of REMS technology at reference anatomical sites for the assessment of osteoporosis has been confirmed in a large series of female patients, spanning from younger and pre-menopausal to elderly women up to 90 years, in a multicenter European clinical context.

Disciplines :

Laboratory medicine & medical technology
Geriatrics

Author, co-author :

Cortet, Bernard; Department of Rheumatology and EA 4490, University-Hospital of Lille, Lille, France

Dennison, Elaine; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK

Diez-Perez, Adolfo; Musculoskeletal Research Group, IMIM (Hospital del Mar Medical Research Institute), Centro de Investigación Biomédica en Red en Fragilidad y Envejecimiento Saludable (CIBERFES), ISCIII, Barcelona, Catalonia, Spain

Locquet, Médéa ; Université de Liège - ULiège

Muratore, Maurizio; Vito Fazzi Hospital, Lecce, Italy

Nogués, Xavier; Musculoskeletal Research Group, IMIM (Hospital del Mar Medical Research Institute), Centro de Investigación Biomédica en Red en Fragilidad y Envejecimiento Saludable (CIBERFES), ISCIII, Barcelona, Catalonia, Spain

Ovejero Crespo, Diana; Musculoskeletal Research Group, IMIM (Hospital del Mar Medical Research Institute), Centro de Investigación Biomédica en Red en Fragilidad y Envejecimiento Saludable (CIBERFES), ISCIII, Barcelona, Catalonia, Spain

Quarta, Eugenio; Vito Fazzi Hospital, Lecce, Italy

Brandi, Maria Luisa; FirmoLab Fondazione F.I.R.M.O., Florence, Italy, Department of Biological, Experimental and Clinical Science, University of Florence, Florence, Italy. Electronic address: m.brandi@dmi.unifi.it

Language :

English

Title :

Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context.

Publication date :

2021

Journal title :

BONE

ISSN :

8756-3282

eISSN :

1873-2763

Publisher :

Elsevier Inc., United States

Volume :

143

Pages :

115786

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S8756328220305743?httpAccept=text/xml

Available on ORBi :

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