[en] In this longitudinal study, with a follow-up of 8 years, multidimensional prognostic index (MPI), a product of the comprehensive geriatric assessment, significantly predicted the onset of fractures in older people affected by knee osteoarthritis.
PURPOSE: Frailty may be associated with higher fracture risk, but limited research has been carried out using a multidimensional approach to frailty assessment and diagnosis. The present research aimed to investigate whether the MPI, based on comprehensive geriatric assessment (CGA), is associated with the risk of fractures in the Osteoarthritis Initiative (OAI) study.
METHODS: Community-dwellers affected by knee OA or at high risk for this condition were followed-up for 8 years. A standardized CGA including information on functional, nutritional, mood, comorbidity, medication, quality of life, and co-habitation status was used to calculate the MPI. Fractures were diagnosed using self-reported information. Cox's regression analysis was carried out and results are reported as hazard ratios (HRs), with their 95% confidence intervals (CIs), adjusted for potential confounders.
RESULTS: The sample consisted of 4024 individuals (mean age 61.0 years, females = 59.0%). People with incident fractures had a significant higher MPI baseline value than those without (0.42 ± 0.18 vs. 0.40 ± 0.17). After adjusting for several potential confounders, people with an MPI over 0.66 (HR = 1.49; 95%CI: 1.11-2.00) experienced a higher risk of fractures. An increase in 0.10 point in MPI score corresponded to an increase in fracture risk of 4% (HR = 1.04; 95%CI: 1.008-1.07). Higher MPI values were also associated with a higher risk of non-vertebral clinical fractures.
CONCLUSION: Higher MPI values at baseline were associated with an increased risk of fractures, reinforcing the importance of CGA in predicting fractures in older people affected by knee OA.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Veronese, Nicola; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141 90127, Palermo, Italy. nicola.veronese@unipa.it ; Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. nicola.veronese@unipa.it
Smith, Lee; The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
Zigoura, Ekaterini; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, Genova, Italy
Barbagallo, Mario; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141 90127, Palermo, Italy
Dominguez, Ligia J; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141 90127, Palermo, Italy
Barone, Antonella; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, Genova, Italy
Cella, Alberto; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, Genova, Italy
Cooper, Cyrus; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK ; NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK
Rizzoli, Renè; Division of Bone Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland
Reginster, Jean-Yves ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES) ; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium ; Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
Maggi, Stefania; Aging Branch, Neuroscience Institute, National Research Council, Padua, Italy
Pilotto, Alberto; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Frailty Area, E.O. Galliera Hospital, Genova, Italy ; Department of Interdisciplinary Medicine, University of Bari, Bari, Italy
Language :
English
Title :
Multidimensional prognostic index and the risk of fractures: an 8-year longitudinal cohort study in the Osteoarthritis Initiative.
Publication date :
2022
Journal title :
Archives of Osteoporosis
ISSN :
1862-3522
eISSN :
1862-3514
Publisher :
Springer Science and Business Media Deutschland GmbH, England
The OAI is a public–private partnership comprising five contracts (N01-AR-2–2258; N01-AR-2–2259; N01-AR-2–2260; N01-AR-2–2261; N01-AR-2–2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.
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