Article (Scientific journals)
Exercise Limitation after Critical Versus Mild COVID-19 Infection: A Metabolic Perspective
Joris, Maurice; Pincemail, Joël; COLSON, Camille et al.
2022In Journal of Clinical Medicine, 11 (15), p. 4322
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Abstract :
[en] Exercise limitation in COVID-19 survivors is poorly explained. In this retrospective study, cardiopulmonary exercise testing (CPET) was coupled with an oxidative stress assessment in COVID-19 critically ill survivors (ICU group). Thirty-one patients were included in this group. At rest, their oxygen uptake (VO2) was elevated (8 [5.6–9.7] mL/min/kg). The maximum effort was reached at low values of workload and VO2 (66 [40.9–79.2]% and 74.5 [62.6–102.8]% of the respective predicted values). The ventilatory equivalent for carbon dioxide remained within normal ranges. Their metabolic efficiency was low: 15.2 [12.9–17.8]%. The 50% decrease in VO2 after maximum effort was delayed, at 130 [120–170] s, with a still-high respiratory exchange ratio (1.13 [1–1.2]). The blood myeloperoxidase was elevated (92 [75.5–106.5] ng/mL), and the OSS was altered. The CPET profile of the ICU group was compared with long COVID patients after mid-disease (MLC group) and obese patients (OB group). The MLC patients (n = 23) reached peak workload and predicted VO2 values, but their resting VO2, metabolic efficiency, and recovery profiles were similar to the ICU group to a lesser extent. In the OB group (n = 15), no hypermetabolism at rest was observed. In conclusion, the exercise limitation after a critical COVID-19 bout resulted from an altered metabolic profile in the context of persistent inflammation and oxidative stress. Altered exercise and metabolic profiles were also observed in the MLC group. The contribution of obesity on the physiopathology of exercise limitation after a critical bout of COVID-19 did not seem relevant.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Joris, Maurice
Pincemail, Joël ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
COLSON, Camille ;  Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs chirurgie (+1D)
JORIS, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
CALMES, Doriane ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Cavalier, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
Misset, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
MINGUET, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Rousseau, Anne-Françoise  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Language :
English
Title :
Exercise Limitation after Critical Versus Mild COVID-19 Infection: A Metabolic Perspective
Publication date :
25 July 2022
Journal title :
Journal of Clinical Medicine
eISSN :
2077-0383
Publisher :
MDPI AG
Volume :
11
Issue :
15
Pages :
4322
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 July 2022

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