Article (Scientific journals)
Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency—A Case Report
DEPUIS, Zoé; Gatineau-Sailliant, Sophie; Ketelslegers, Olivier et al.
2022In Pediatric Reports, 14 (1), p. 106-114
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Keywords :
Pediatrics
Abstract :
[en] We report a case of severe pancytopenia in a 15-year-old patient due to a severe deficiency in vitamin B12 and folic acid, probably of nutritional origin. The clinical and biological course was favorable after vitamin supplementation. With this case, we discuss the diagnostic approach of pancytopenia with megaloblastic anemia in children and adolescents, as well as the mechanisms involved in vitamin B12 and B9 deficiency. Hypovitaminosis B12 is known in its severe form but its diagnosis is often made difficult by insidious signs and symptoms. Traditional intramuscular replacement therapy has now proven to be effective orally. The clinical manifestations of folic acid deficiency are relatively similar to those of vitamin B12 deficiency, reflecting their intricate co-enzymatic functions. Its supplementation is administered orally.
Disciplines :
Pediatrics
Hematology
Author, co-author :
DEPUIS, Zoé ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Gatineau-Sailliant, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Ketelslegers, Olivier;  CHR Citadelle - Centre Hospitalier Régional de la Citadelle > Laboratory medicine
Minon, Jean-Marc;  CHR Citadelle - Centre Hospitalier Régional de la Citadelle > Laboratory medicine
SEGHAYE, Marie-Christine ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Vasbien, Myriam;  CHR Citadelle - Centre Hospitalier Régional de la Citadelle > Laboratory medicine
DRESSE, Marie-Françoise  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Language :
English
Title :
Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency—A Case Report
Publication date :
03 March 2022
Journal title :
Pediatric Reports
ISSN :
2036-749X
eISSN :
2036-7503
Publisher :
MDPI AG
Volume :
14
Issue :
1
Pages :
106-114
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 July 2022

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