Animals; Bone and Bones; Computer Simulation; Humans; Prostheses and Implants; Tissue Engineering; Automation; Biofabrication; Biomanufacturing; Clinical translation; Endochondral ossification; In silico tools; Omics; Scale-up; Tissue engineering
Abstract :
[en] A decade after the term developmental engineering (DE) was coined to indicate the use of developmental processes as blueprints for the design and development of engineered living implants, a myriad of proof-of-concept studies demonstrate the potential of this approach in small animal models. This review provides an overview of DE work, focusing on applications in bone regeneration. Enabling technologies allow to quantify the distance between in vitro processes and their developmental counterpart, as well as to design strategies to reduce that distance. By embedding Nature's robust mechanisms of action in engineered constructs, predictive large animal data and subsequent positive clinical outcomes can be gradually achieved. To this end, the development of next generation biofabrication technologies should provide the necessary scale and precision for robust living bone implant biomanufacturing.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Papantoniou, Ioannis; Institute of Chemical Engineering Sciences, Foundation for Research and
Nilsson Hall, Gabriella; Skeletal Biology & Engineering Research Center, KU Leuven, Herestraat 49 (813),
Loverdou, Niki ; Université de Liège - ULiège > GIGA ; Prometheus, The KU Leuven R&D Division for Skeletal Tissue Engineering,
Lesage, Raphaelle; Prometheus, The KU Leuven R&D Division for Skeletal Tissue Engineering,
Herpelinck, Tim; Skeletal Biology & Engineering Research Center, KU Leuven, Herestraat 49 (813),
Mendes, Luis; Skeletal Biology & Engineering Research Center, KU Leuven, Herestraat 49 (813),
Geris, Liesbet ; Université de Liège - ULiège > GIGA > GIGA In silico medecine - Biomechanics Research Unit ; Skeletal Biology & Engineering Research Center, KU Leuven, Herestraat 49 (813),
Language :
English
Title :
Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.
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