Algorithms; Artificial Intelligence; Cardiology; Humans; Precision Medicine; Artificial intelligence; Computational modelling; Digital twin; Precision medicine
Abstract :
[en] Providing therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the 'digital twin' of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Corral-Acero, Jorge; Department of Engineering Science, University of Oxford, Oxford, UK.
Margara, Francesca; Department of Computer Science, British Heart Foundation Centre of Research
Marciniak, Maciej; Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical
Rodero, Cristobal; Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical
Loncaric, Filip; Institut Clínic Cardiovascular, Hospital Clínic, Universitat de Barcelona,
Feng, Yingjing; IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux ; IMB, UMR 5251, University of Bordeaux, Talence F-33400, France.
Gilbert, Andrew; GE Vingmed Ultrasound AS, Horton, Norway.
Fernandes, Joao F; Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical
Bukhari, Hassaan A; IMB, UMR 5251, University of Bordeaux, Talence F-33400, France. ; Aragón Institute of Engineering Research, Universidad de Zaragoza, IIS Aragón,
Wajdan, Ali; The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Martinez, Manuel Villegas; The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Santos, Mariana Sousa; FEops NV, Ghent, Belgium.
Shamohammdi, Mehrdad; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The
Luo, Hongxing; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The
Westphal, Philip; Medtronic PLC, Bakken Research Center, Maastricht, the Netherlands.
Leeson, Paul; Radcliffe Department of Medicine, Division of Cardiovascular Medicine, Oxford
DiAchille, Paolo; Healthcare and Life Sciences Research, IBM T.J. Watson Research Center, Yorktown
Gurev, Viatcheslav; Healthcare and Life Sciences Research, IBM T.J. Watson Research Center, Yorktown
Mayr, Manuel; King's British Heart Foundation Centre, King's College London, London, UK.
Geris, Liesbet ; Université de Liège - ULiège > GIGA > GIGA In silico medecine - Biomechanics Research Unit ; Virtual Physiological Human Institute, Leuven, Belgium.
Pathmanathan, Pras; Center for Devices and Radiological Health, U.S. Food and Drug Administration,
Morrison, Tina; Center for Devices and Radiological Health, U.S. Food and Drug Administration,
Cornelussen, Richard; Medtronic PLC, Bakken Research Center, Maastricht, the Netherlands.
Prinzen, Frits; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The
Delhaas, Tammo; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The
Doltra, Ada; Institut Clínic Cardiovascular, Hospital Clínic, Universitat de Barcelona,
Sitges, Marta; Institut Clínic Cardiovascular, Hospital Clínic, Universitat de Barcelona, ; CIBERCV, Instituto de Salud Carlos III, (CB16/11/00354), CERCA
Vigmond, Edward J; IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux ; IMB, UMR 5251, University of Bordeaux, Talence F-33400, France.
Zacur, Ernesto; Department of Engineering Science, University of Oxford, Oxford, UK.
Grau, Vicente; Department of Engineering Science, University of Oxford, Oxford, UK.
Rodriguez, Blanca; Department of Computer Science, British Heart Foundation Centre of Research
Remme, Espen W; The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Niederer, Steven; Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical
Mortier, Peter; FEops NV, Ghent, Belgium.
McLeod, Kristin; GE Vingmed Ultrasound AS, Horton, Norway.
Potse, Mark; IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux ; IMB, UMR 5251, University of Bordeaux, Talence F-33400, France. ; Inria Bordeaux Sud-Ouest, CARMEN team, Talence F-33400, France.
Pueyo, Esther; Aragón Institute of Engineering Research, Universidad de Zaragoza, IIS Aragón, ; CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid,
Bueno-Orovio, Alfonso; Department of Computer Science, British Heart Foundation Centre of Research
Lamata, Pablo; Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical
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