Article (Scientific journals)
Safer chemicals using less animals: kick-off of the European ONTOX project.
Vinken, Mathieu; Benfenati, Emilio; Busquet, François et al.
2021In Toxicology, 458, p. 152846
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Keywords :
Animal Testing Alternatives; Animals; Artificial Intelligence; Computer Simulation; European Union; Gene Ontology; Humans; In Vitro Techniques; Risk Assessment; Toxicity Tests; 3Rs; Artificial intelligence; European project; In silico; In vitro; ONTOX; Ontology; Systemic toxicity
Abstract :
[en] The 3Rs concept, calling for replacement, reduction and refinement of animal experimentation, is receiving increasing attention around the world, and has found its way to legislation, in particular in the European Union. This is aligned by continuing high-level efforts of the European Commission to support development and implementation of 3Rs methods. In this respect, the European project called "ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment" was recently initiated with the goal to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21(st) century toxicity testing and next generation risk assessment. ONTOX will deliver a generic strategy to create new approach methodologies (NAMs) in order to predict systemic repeated dose toxicity effects that, upon combination with tailored exposure assessment, will enable human risk assessment. For proof-of-concept purposes, focus is put on NAMs addressing adversities in the liver, kidneys and developing brain induced by a variety of chemicals. The NAMs each consist of a computational system based on artificial intelligence and are fed by biological, toxicological, chemical and kinetic data. Data are consecutively integrated in physiological maps, quantitative adverse outcome pathway networks and ontology frameworks. Supported by artificial intelligence, data gaps are identified and are filled by targeted in vitro and in silico testing. ONTOX is anticipated to have a deep and long-lasting impact at many levels, in particular by consolidating Europe's world-leading position regarding the development, exploitation, regulation and application of animal-free methods for human risk assessment of chemicals.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Vinken, Mathieu;  Research Group of In VitroToxicology and Dermato-Cosmetology, Department of
Benfenati, Emilio;  Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche
Busquet, François;  Altertox, Brussels, Belgium.
Castell, José;  Department of Biochemistry and Molecular Biology, University of Valencia-Spain,
Clevert, Djork-Arné;  Machine Learning Research, Bayer AG, Berlin, Germany.
de Kok, Theo M;  Department of Toxicogenomics, GROW School for Oncology and Developmental Biology,
Dirven, Hubert;  Department of Environmental Health, Norwegian Institute of Public Health, Oslo,
Fritsche, Ellen;  IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany,
Geris, Liesbet  ;  Université de Liège - ULiège > GIGA > GIGA In silico medecine - Biomechanics Research Unit
Gozalbes, Rafael;  ProtoQSAR SL, European Center of Innovative Companies, Technological Park of
Hartung, Thomas;  Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of
Jennen, Danyel;  Department of Toxicogenomics, GROW School for Oncology and Developmental Biology,
Jover, Ramiro;  Department of Biochemistry and Molecular Biology, University of Valencia-Spain,
Kandarova, Helena;  Centre of Experimental Medicine SAS, Slovak Academy of Sciences, Bratislava,
Kramer, Nynke;  Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the
Krul, Cyrille;  Innovative Testing in Life Sciences and Chemistry, Hogeschool Utrecht University
Luechtefeld, Thomas;  ToxTrack, Bethesda, MD, USA.
Masereeuw, Rosalinde;  Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht
Roggen, Erwin;  3Rs Management and Consulting ApS, Lyngby, Denmark.
Schaller, Stephan;  esqLABS GmbH, Saterland, Germany.
Vanhaecke, Tamara;  Research Group of In VitroToxicology and Dermato-Cosmetology, Department of
Yang, Chihae;  Molecular Networks GmbH, Nürnberg, Germany.
Piersma, Aldert H;  Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the
More authors (13 more) Less
Language :
English
Title :
Safer chemicals using less animals: kick-off of the European ONTOX project.
Publication date :
30 June 2021
Journal title :
Toxicology
ISSN :
0300-483X
eISSN :
1879-3185
Volume :
458
Pages :
152846
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021 Elsevier B.V. All rights reserved.
Available on ORBi :
since 29 June 2022

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