Abstract :
[en] A defining aspect of brain organization is its spatial heterogeneity, which gives rise to multiple topographies at different scales. Brain parcellation — defining distinct partitions in the brain, be they areas or networks that comprise multiple discontinuous but closely interacting regions — is thus fundamental for understanding brain organization and function. The past decade has seen an explosion of in vivo MRI-based approaches to identify and parcellate the brain on the basis of a wealth of different features, ranging from local properties of brain tissue to long-range connectivity patterns, in addition to structural and functional markers. In this talk, I will introduce brain parcellation and provide an overview of the main approaches. I will then focus more particularly on connectivity-based parcellation (CBP) applied to different connectivity features. This will lead us to discuss convergence and divergence across features and the related open challenges.
Articles discussed:
Eickhoff, S. B., Yeo, B. T. T., & Genon, S. (2018). Imaging-based parcellations of the human brain. Nat Rev Neurosci, 19(11), 672-686. doi:10.1038/s41583-018-0071-7
Genon, S., Bernhardt, B. C., La Joie, R., Amunts, K., & Eickhoff, S. B. (2021). The many dimensions of human hippocampal organization and (dys) function. Trends in Neurosciences.
Plachti, A., Eickhoff, S. B., Hoffstaedter, F., Patil, K. R., Laird, A. R., Fox, P. T., . . . Genon, S. (2019). Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient. Cereb Cortex, 29(11), 4595-4612. doi:10.1093/cercor/bhy336
Software employed:
CBBtools: https://github.com/inm7/cbptools
Data:
https://www.humanconnectome.org/study/hcp-young-adult/data-releases
