Article (Scientific journals)
Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection.
Selinger, Christian; Rahmoun, Massilva; Murall, Carmen Lia et al.
2021In Immunologic Research, 69 (3), p. 255-263
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Keywords :
Cytokines; Human papillomavirus; Mucosal immunity; Natural history; IL1A protein, human; Interleukin-12 Subunit p40; Interleukin-1alpha; Adolescent; Adult; Alphapapillomavirus/immunology; Alphapapillomavirus/isolation & purification; Cervix Uteri/immunology; Cervix Uteri/metabolism; Cervix Uteri/virology; Female; Humans; Interleukin-12 Subunit p40/analysis; Interleukin-12 Subunit p40/metabolism; Interleukin-1alpha/analysis; Interleukin-1alpha/metabolism; Longitudinal Studies; Macrophages/immunology; Macrophages/metabolism; Papillomavirus Infections/blood; Papillomavirus Infections/immunology; Papillomavirus Infections/virology; Vagina/immunology; Vagina/metabolism; Vagina/virology; Young Adult; Alphapapillomavirus; Cervix Uteri; Macrophages; Papillomavirus Infections; Vagina; Immunology
Abstract :
[en] Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346.
Disciplines :
Immunology & infectious disease
Author, co-author :
Selinger, Christian ;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France. christian.selinger@ird.fr ; Institut de Recherche Pour Le Développement, 911 Avenue Agropolis, BP 64501, 34394, Montpellier cedex 5, France. christian.selinger@ird.fr
Rahmoun, Massilva;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
Murall, Carmen Lia;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
Bernat, Claire;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
Boué, Vanina;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
Bonneau, Marine;  Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire de Montpellier, University of Montpellier, Montpellier, France
Graf, Christelle;  Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire de Montpellier, University of Montpellier, Montpellier, France
Grasset, Sophie;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
Groc, Soraya;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
Reynes, Jacques;  Department of Infectious and Tropical Diseases, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
Hirtz, Christophe;  IRMB-PPC, INM, Univ Montpellier, CHU Montpellier, INSERM CNRS, Montpellier, France
Jacobs, Nathalie  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Alizon, Samuel;  Laboratoire MIVEGEC (UMR CNRS 5290, IRD 224, UM), Montpellier, France
More authors (3 more) Less
Language :
English
Title :
Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection.
Publication date :
June 2021
Journal title :
Immunologic Research
ISSN :
0257-277X
eISSN :
1559-0755
Publisher :
Springer, United States
Volume :
69
Issue :
3
Pages :
255-263
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ERC - European Research Council [BE]
Funding text :
This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program [grant agreement No 648963 to SA]. The sponsor had no role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.
Available on ORBi :
since 14 June 2022

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