Article (Scientific journals)
Glycosyltransferases encoded by viruses.
Markine-Goriaynoff, Nicolas; Gillet, Laurent; Van Etten, James L et al.
2004In Journal of General Virology, 85 (Pt 10), p. 2741-54
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Keywords :
Bacteriophages/enzymology; Baculoviridae/enzymology; Glycosyltransferases/genetics/physiology; Herpesvirus 4, Bovine/enzymology; Phycodnaviridae/enzymology; Poxviridae/enzymology; Viruses/enzymology
Abstract :
[en] Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important as genomics, transcriptomics and proteomics. For millions of years, viruses have been co-evolving with their hosts. Consequently, during this co-evolution process, viruses have acquired mechanisms to mimic, hijack or sabotage host processes that favour their replication, including mechanisms to modify the glycome. The importance of the glycome in the regulation of host-virus interactions has recently led to a new concept called 'glycovirology'. One fascinating aspect of glycovirology is the study of how viruses affect the glycome. Viruses reach that goal either by regulating expression of host glycosyltransferases or by expressing their own glycosyltransferases. This review describes all virally encoded glycosyltransferases and discusses their established or putative functions. The description of these enzymes illustrates several intriguing aspects of virology and provides further support for the importance of glycomics in biological processes.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Markine-Goriaynoff, Nicolas 
Gillet, Laurent  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Van Etten, James L
Korres, Haralambos
Verma, Naresh
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie et vaccinologie
Language :
English
Title :
Glycosyltransferases encoded by viruses.
Publication date :
2004
Journal title :
Journal of General Virology
ISSN :
0022-1317
eISSN :
1465-2099
Publisher :
Society for General Microbiology, London, United Kingdom
Volume :
85
Issue :
Pt 10
Pages :
2741-54
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 November 2009

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