Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
[en] The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Théry, Clotilde ; Institut Curie, INSERM U932, PSL Research University, Paris, France
Witwer, Kenneth W ; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA ; The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA
Aikawa, Elena; Brigham and Women's Hospital, Center for Interdisciplinary Cardiovascular Sciences, Boston, MA, USA ; Harvard Medical School, Cardiovascular Medicine, Boston, MA, USA
Alcaraz, Maria Jose; Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), University of Valencia, Polytechnic University of Valencia, Valencia, Spain
Anderson, Johnathon D; University of California, Davis, Department of Otolaryngology, Davis, CA, USA
Andriantsitohaina, Ramaroson; INSERM U1063, Université d'Angers, CHU d'Angers, Angers, France
Antoniou, Anna; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany ; University Hospital Bonn (UKB), Bonn, Germany
Arab, Tanina; Université de Lille, INSERM, U-1192, Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse - PRISM, Lille, France
Archer, Fabienne; University of Lyon, INRA, EPHE, UMR754 Viral Infections and Comparative Pathology, Lyon, France
Atkin-Smith, Georgia K; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Ayre, D Craig; Atlantic Cancer Research Institute, Moncton, Canada ; Mount Allison University, Department of Chemistry and Biochemistry, Sackville, Canada
Bach, Jean-Marie; Université Bretagne Loire, Oniris, INRA, IECM, Nantes, France
Bachurski, Daniel; University of Cologne, Department of Internal Medicine I, Cologne, Germany
Baharvand, Hossein; Royan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center, Department of Stem Cells and Developmental Biology, Tehran, Iran ; University of Science and Culture, ACECR, Department of Developmental Biology, Tehran, Iran
Balaj, Leonora; Massachusetts General Hospital, Department of Neurosurgery, Boston, MA, USA
Baldacchino, Shawn; University of Malta, Department of Pathology, Msida, Malta
Bauer, Natalie N; University of South Alabama, Department of Pharmacology, Center for Lung Biology, Mobile, AL, USA
Baxter, Amy A; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Bebawy, Mary; University of Technology Sydney, Discipline of Pharmacy, Graduate School of Health, Sydney, Australia
Beckham, Carla; University of Rochester, Rochester, NY, USA
Bedina Zavec, Apolonija; National Institute of Chemistry, Department of Molecular Biology and Nanobiotechnology, Ljubljana, Slovenia
Benmoussa, Abderrahim; Université Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada
Berardi, Anna C; Ospedale Santo Spirito, Pescara, Italy
Bergese, Paolo; CSGI - Research Center for Colloids and Nanoscience, Florence, Italy ; INSTM - National Interuniversity Consortium of Materials Science and Technology, Florence, Italy ; University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy
Bielska, Ewa; University of Birmingham, Institute of Microbiology and Infection, Birmingham, UK
Blenkiron, Cherie; University of Auckland, Auckland, New Zealand
Bobis-Wozowicz, Sylwia; Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland
Boilard, Eric; Université Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada
Boireau, Wilfrid; FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France
Bongiovanni, Antonella; Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy
Borràs, Francesc E; Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group, Badalona, Spain ; Germans Trias i Pujol University Hospital, Nephrology Service, Badalona, Spain ; Universitat Autònoma de Barcelona, Department of Cell Biology, Physiology & Immunology, Barcelona, Spain
Bosch, Steffi; Université Bretagne Loire, Oniris, INRA, IECM, Nantes, France
Boulanger, Chantal M; INSERM UMR-S 970, Paris Cardiovascular Research Center, Paris, France ; Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Breakefield, Xandra; Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Department of Neurology and Radiology, Boston, MA, USA
Breglio, Andrew M; Icahn School of Medicine at Mount Sinai, New York City, NY, USA ; National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, USA
Brennan, Meadhbh Á; Harvard University, School of Engineering and Applied Sciences, Cambridge, MA, USA ; Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Boston, MA, USA ; Université de Nantes, INSERM UMR 1238, Bone Sarcoma and Remodeling of Calcified Tissues, PhyOS, Nantes, France
Brigstock, David R; Nationwide Children's Hospital, Columbus, OH, USA ; The Ohio State University, Columbus, OH, USA
Brisson, Alain; UMR-CBMN, CNRS-Université de Bordeaux, Bordeaux, France
Broekman, Marike Ld; Haaglanden Medical Center, Department of Neurosurgery, The Hague, The Netherlands ; Leiden University Medical Center, Department of Neurosurgery, Leiden, The Netherlands ; Massachusetts General Hospital, Department of Neurology, Boston, MA, USA
Bromberg, Jacqueline F; Memorial Sloan Kettering Cancer Center, Department of Medicine, New York City, NY, USA ; Weill Cornell Medicine, Department of Medicine, New York City, NY, USA
Bryl-Górecka, Paulina; Lund University, Department of Cardiology, Lund, Sweden
Buch, Shilpa; University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA
Buck, Amy H; University of Edinburgh, Institute of Immunology & Infection Research, Edinburgh, UK
Burger, Dylan; Kidney Research Centre, Ottawa, Canada ; Ottawa Hospital Research Institute, Ottawa, Canada ; University of Ottawa, Ottawa, Canada
Busatto, Sara; Mayo Clinic, Department of Transplantation, Jacksonville, FL, USA ; University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy
Buschmann, Dominik; Technical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany
Bussolati, Benedetta; University of Torino, Department of Molecular Biotechnology and Health Sciences, Torino, Italy
Buzás, Edit I; MTA-SE Immuno-Proteogenomics Research Groups, Budapest, Hungary ; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Byrd, James Bryan; University of Michigan, Department of Medicine, Ann Arbor, MI, USA
Camussi, Giovanni; University of Torino, Department of Medical Sciences, Torino, Italy
Carter, David Rf; Oxford Brookes University, Department of Biological and Medical Sciences, Oxford, UK
Caruso, Sarah; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Chamley, Lawrence W; University of Auckland, Department of Obstetrics and Gynaecology, Auckland, New Zealand
Chang, Yu-Ting; National Taiwan University Hospital, Department of Internal Medicine, Taipei, Taiwan
Chen, Chihchen; National Tsing Hua University, Department of Power Mechanical Engineering, Hsinchu, Taiwan ; National Tsing Hua University, Institute of Nanoengineering and Microsystems, Hsinchu, Taiwan
Chen, Shuai; Leibniz Institute for Farm Animal Biology (FBN), Institute of Reproductive Biology, Dummerstorf, Germany
Cheng, Lesley; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Chin, Andrew R; Cedars-Sinai Medical Center, Los Angeles, CA, USA
Clayton, Aled; Cardiff University, School of Medicine, Cardiff, UK
Clerici, Stefano P; UNICAMP, Institute of Biology, Campinas, Brazil
Cocks, Alex; Cardiff University, School of Medicine, Cardiff, UK
Cocucci, Emanuele; The Ohio State University, College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry, Columbus, OH, USA ; The Ohio State University, Comprehensive Cancer Center, Columbus, OH, USA
Coffey, Robert J; Vanderbilt University Medical Center, Epithelial Biology Center, Department of Medicine, Nashville, TN, USA
Cordeiro-da-Silva, Anabela; University of Porto, Faculty of Pharmacy (FFUP), IBMC/I3S, Porto, Portugal
Couch, Yvonne; University of Oxford, Radcliffe Department of Medicine, Acute Stroke Programme - Investigative Medicine, Oxford, UK
Coumans, Frank Aw; Academic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry and Vesicle Observation Centre, Amsterdam, The Netherlands
Coyle, Beth; The University of Nottingham, School of Medicine, Children's Brain Tumour Research Centre, Nottingham, UK
Crescitelli, Rossella; University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden
Criado, Miria Ferreira; University of São Paulo, Ribeirão Preto Medical School, Ribeirão Preto, Brazil
D'Souza-Schorey, Crislyn; University of Notre Dame, Department of Biological Sciences, Notre Dame, IN, USA
Das, Saumya; Massachusetts General Hospital, Boston, MA, USA
Datta Chaudhuri, Amrita; The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA
de Candia, Paola; IRCCS MultiMedica, Milan, Italy
De Santana, Eliezer F; The Sociedade Beneficente Israelita Brasileira Albert Einstein, São Paulo, Brazil
De Wever, Olivier; Cancer Research Institute Ghent, Ghent, Belgium ; Ghent University, Department of Radiation Oncology and Experimental Cancer Research, Laboratory of Experimental Cancer Research, Ghent, Belgium
Del Portillo, Hernando A; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain ; Institut d'Investigació Germans Trias i Pujol (IGTP), PVREX group, Badalona, Spain ; ISGlobal, Hospital Clínic - Universitat de Barcelona, PVREX Group, Barcelona, Spain
Demaret, Tanguy ; Université de Liège - ULiège > Faculté de Médecine > Mast. spéc. gén. clin. ; Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
Devitt, Andrew; Aston University, School of Life & Health Sciences, Birmingham, UK
Dhondt, Bert; Cancer Research Institute Ghent, Ghent, Belgium ; Ghent University Hospital, Department of Urology, Ghent, Belgium ; Ghent University, Department of Radiation Oncology and Experimental Cancer Research, Laboratory of Experimental Cancer Research, Ghent, Belgium
Di Vizio, Dolores; Cedars-Sinai Medical Center, Los Angeles, CA, USA
Dieterich, Lothar C; ETH Zurich, Institute of Pharmaceutical Sciences, Zurich, Switzerland
Dolo, Vincenza; University of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy
Dominguez Rubio, Ana Paula; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina
Dominici, Massimo; TPM of Mirandola, Mirandola, Italy ; University of Modena and Reggio Emilia, Division of Oncology, Modena, Italy
Dourado, Mauricio R; University of Campinas, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, Brazil ; University of Oulu, Faculty of Medicine, Cancer and Translational Medicine Research Unit, Oulu, Finland
Driedonks, Tom Ap; Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands
Duarte, Filipe V; Exogenus Therapeutics, Cantanhede, Portugal
Duncan, Heather M; McGill University, Division of Experimental Medicine, Montreal, Canada ; McGill University, The Research Institute of the McGill University Health Centre, Child Health and Human Development Program, Montreal, Canada
Eichenberger, Ramon M; James Cook University, Australian Institute of Tropical Health and Medicine, Centre for Biodiscovery and Molecular Development of Therapeutics, Cairns, Australia
Ekström, Karin; University of Gothenburg, Institute of Clinical Sciences at Sahlgrenska Academy, Department of Biomaterials, Gothenburg, Sweden
El Andaloussi, Samir; Evox Therapeutics Limited, Oxford, UK ; Karolinska Institute, Stockholm, Sweden
Elie-Caille, Celine; FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France
Erdbrügger, Uta; University of Virginia Health System, Department of Medicine, Division of Nephrology, Charlottesville, VA, USA
Falcón-Pérez, Juan M; CIC bioGUNE, CIBERehd, Exosomes Laboratory & Metabolomics Platform, Derio, Spain ; IKERBASQUE Research Science Foundation, Bilbao, Spain
Fatima, Farah; University of São Paulo, Ribeirão Preto Medical School, Department of Pathology and Forensic Medicine, Ribeirão Preto, Brazil
Fish, Jason E; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada ; University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada
Flores-Bellver, Miguel; University of Colorado, School of Medicine, Department of Ophthalmology, Cell Sight-Ocular Stem Cell and Regeneration Program, Aurora, CO, USA
Försönits, András; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Frelet-Barrand, Annie; FEMTO-ST Institute, UBFC, CNRS, ENSMM, UTBM, Besançon, France
Fricke, Fabia; German Cancer Research Center (DKFZ), Clinical Cooperation Unit Applied Tumor Biology, Heidelberg, Germany ; University Hospital Heidelberg, Institute of Pathology, Applied Tumor Biology, Heidelberg, Germany
Fuhrmann, Gregor; Helmholtz-Centre for Infection Research, Braunschweig, Germany ; Helmholtz-Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany ; Saarland University, Saarbrücken, Germany
Gabrielsson, Susanne; Karolinska Institute, Department of Medicine Solna, Division for Immunology and Allergy, Stockholm, Sweden
Gámez-Valero, Ana; Germans Trias i Pujol Research Institute (IGTP), Can Ruti Campus, REMAR-IVECAT Group, Badalona, Spain ; Universitat Autònoma de Barcelona, Hospital Universitari and Health Sciences Research Institute Germans Trias i Pujol, Department of Pathology, Barcelona, Spain
Gardiner, Chris; University College London, London, UK
Gärtner, Kathrin; Helmholtz Center Munich German Research Center for Environmental Health, Research Unit Gene Vectors, Munich, Germany
Gaudin, Raphael; INSERM U1110, Strasbourg, France ; Université de Strasbourg, Strasbourg, France
Gho, Yong Song; POSTECH (Pohang University of Science and Technology), Department of Life Sciences, Pohang, South Korea
Giebel, Bernd; University Hospital Essen, University Duisburg-Essen, Institute for Transfusion Medicine, Essen, Germany
Gilbert, Caroline; Université Laval, Centre de Recherche du CHU de Québec, Department of Infectious Diseases and Immunity, Quebec City, Canada
Gimona, Mario; Paracelsus Medical University, GMP Unit, Salzburg, Austria
Giusti, Ilaria; University of L'Aquila, Department of Life, Health and Environmental Sciences, L'Aquila, Italy
Goberdhan, Deborah Ci; University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford, UK
Görgens, André; Evox Therapeutics Limited, Oxford, UK ; Karolinska Institute, Clinical Research Center, Department of Laboratory Medicine, Stockholm, Sweden ; University Hospital Essen, University Duisburg-Essen, Institute for Transfusion Medicine, Essen, Germany
Gorski, Sharon M; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada ; Simon Fraser University, Department of Molecular Biology and Biochemistry, Burnaby, Canada
Greening, David W; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Gross, Julia Christina; University Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany ; University Medical Center Göttingen, Hematology and Oncology, Göttingen, Germany
Gualerzi, Alice; IRCCS Fondazione Don Carlo Gnocchi, Laboratory of Nanomedicine and Clinical Biophotonics (LABION), Milan, Italy
Gupta, Gopal N; Loyola University Chicago, Department of Urology, Maywood, IL, USA
Gustafson, Dakota; University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada
Handberg, Aase; Aalborg University Hospital, Department of Clinical Biochemistry, Aalborg, Denmark ; Aalborg University, Clinical Institute, Aalborg, Denmark
Haraszti, Reka A; University of Massachusetts Medical School, RNA Therapeutics Institute, Worcester, MA, USA
Harrison, Paul; University of Birmingham, Birmingham, UK
Hegyesi, Hargita; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Hendrix, An; Cancer Research Institute Ghent, Ghent, Belgium ; Ghent University, Department of Radiation Oncology and Experimental Cancer Research, Laboratory of Experimental Cancer Research, Ghent, Belgium
Hill, Andrew F; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Hochberg, Fred H; Scintillon Institute, La Jolla, CA, USA ; University of California, San Diego, Department of Neurosurgery, La Jolla, CA, USA
Hoffmann, Karl F; Aberystwyth University, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth, United Kingdom
Holder, Beth; Imperial College London, London, UK ; MRC The Gambia, Fajara, The Gambia
Holthofer, Harry; University Clinic Eppendorf, Hamburg, Germany
Hosseinkhani, Baharak; Hasselt University, Biomedical Research Institute (BIOMED), Department of Medicine and Life Sciences, Hasselt, Belgium
Hu, Guoku; University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA
Huang, Yiyao; Nanfang Hospital, Southern Medical University, Department of Clinical Laboratory Medicine, Guangzhou, China ; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA
Huber, Veronica; Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Immunotherapy of Human Tumors, Milan, Italy
Hunt, Stuart; The University of Sheffield, Sheffield, UK
Ibrahim, Ahmed Gamal-Eldin; Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA
Ikezu, Tsuneya; Boston University School of Medicine, Boston, MA, USA
Inal, Jameel M; University of Hertfordshire, School of Life and Medical Sciences, Biosciences Research Group, Hatfield, UK
Isin, Mustafa; Istanbul University Oncology Institute, Basic Oncology Department, Istanbul, Turkey
Ivanova, Alena; German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg, Germany
Jackson, Hannah K; The University of Nottingham, School of Medicine, Children's Brain Tumour Research Centre, Nottingham, UK
Jacobsen, Soren; Copenhagen Lupus and Vasculitis Clinic, Section 4242 - Rigshospitalet, Copenhagen, Denmark ; University of Copenhagen, Institute of Clinical Medicine, Copenhagen, Denmark
Jay, Steven M; University of Maryland, Fischell Department of Bioengineering, College Park, MD, USA
Jayachandran, Muthuvel; Mayo Clinic, College of Medicine, Department of Physiology and Biomedical Engineering, Rochester, MN, USA
Jenster, Guido; Department of Urology, Rotterdam, The Netherlands
Jiang, Lanzhou; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Johnson, Suzanne M; University of Manchester, Division of Cancer Sciences, Manchester Cancer Research Centre, Manchester, UK
Jones, Jennifer C; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA
Jong, Ambrose; Children's Hospital of Los Angeles, Los Angeles, CA, USA ; University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Jovanovic-Talisman, Tijana; City of Hope Comprehensive Cancer Center, Beckman Research Institute, Department of Molecular Medicine, Duarte, CA, USA
Jung, Stephanie; German Research Center for Environmental Health, Institute for Virology, Munich, Germany
Kalluri, Raghu; University of Texas MD Anderson Cancer Center, Department of Cancer Biology, Metastasis Research Center, Houston, TX, USA
Kano, Shin-Ichi; The Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA
Kaur, Sukhbir; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD, USA
Kawamura, Yumi; National Cancer Center Research Institute, Tokyo, Japan ; University of Tsukuba, Tsukuba, Japan
Keller, Evan T; University of Michigan, Biointerfaces Institute, Ann Arbor, MI, USA ; University of Michigan, Department of Urology, Ann Arbor, MI, USA
Khamari, Delaram; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Khomyakova, Elena; École normale supérieure, Paris, France ; Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia
Khvorova, Anastasia; University of Massachusetts Medical School, RNA Therapeutics Institute, Worcester, MA, USA
Kierulf, Peter; Oslo University Hospital, Department of Medical Biochemistry, Blood Cell Research Group, Oslo, Norway
Kim, Kwang Pyo; Kyung Hee University, Department of Applied Chemistry, Yongin, Korea
Kislinger, Thomas; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada ; University of Toronto, Department of Medical Biophysics, Toronto, Canada
Klingeborn, Mikael; Duke University, Department of Ophthalmology, Durham, NC, USA
Klinke, David J; West Virginia University, Department of Chemical and Biomedical Engineering and WVU Cancer Institute, Morgantown, WV, USA ; West Virginia University, Department of Microbiology Immunology and Cell Biology, Morgantown, WV, USA
Kornek, Miroslaw; German Armed Forces Central Hospital, Department of General, Visceral and Thoracic Surgery, Koblenz, Germany ; Saarland University Medical Center, Department of Medicine II, Homburg, Germany
Kosanović, Maja M; University of Belgrade, Institute for the Application of Nuclear Energy, INEP, Belgrade, Serbia
Kovács, Árpád Ferenc; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Krämer-Albers, Eva-Maria; University of Mainz, Institute of Developmental Biology and Neurobiology, Mainz, Germany
Krasemann, Susanne; University Medical Center Hamburg-Eppendorf, Institute of Neuropathology, Hamburg, Germany
Krause, Mirja; Hudson Institute of Medical Research, Melbourne, Australia
Kurochkin, Igor V; Central Research Laboratories, Sysmex Co., Kobe, Japan
Kusuma, Gina D; Hudson Institute of Medical Research, Melbourne, Australia ; Monash University, Melbourne, Australia
Kuypers, Sören; Hasselt University, Biomedical Research Institute (BIOMED), Hasselt, Belgium
Laitinen, Saara; Finnish Red Cross Blood Service, Research and Development, Helsinki, Finland
Langevin, Scott M; Cincinnati Cancer Center, Cincinnati, OH, USA ; University of Cincinnati College of Medicine, Cincinnati, OH, USA
Languino, Lucia R; Thomas Jefferson University, Sidney Kimmel Medical School, Department of Cancer Biology, Philadelphia, PA, USA
Lannigan, Joanne; University of Virginia, Flow Cytometry Core, School of Medicine, Charlottesville, VA, USA
Lässer, Cecilia; University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden
Laurent, Louise C; University of California, San Diego, Department of Obstetrics, Gynecology, and Reproductive Sciences, La Jolla, CA, USA
Lavieu, Gregory; Institut Curie, INSERM U932, PSL Research University, Paris, France
Lázaro-Ibáñez, Elisa; AstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg, Sweden
Le Lay, Soazig; INSERM U1063, Université d'Angers, CHU d'Angers, Angers, France
Lee, Myung-Shin; Eulji University, School of Medicine, Daejeon, South Korea
Lee, Yi Xin Fiona; Genome Institute of Singapore, ASTAR, Singapore
Lemos, Debora S; Federal University of Paraná, Department of Genetics, Human Molecular Genetics Laboratory, Curitiba, Brazil
Lenassi, Metka; University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia
Leszczynska, Aleksandra; University of California, San Diego, Department of Pediatrics, San Diego, CA, USA
Li, Isaac Ts; University of British Columbia Okanagan, Kelowna, Canada
Liao, Ke; University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA
Libregts, Sten F; University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Department of Medicine, Cambridge NIHR BRC Cell Phenotyping Hub, Cambridge, UK
Ligeti, Erzsebet; Semmelweis University, Department of Physiology, Budapest, Hungary
Lim, Rebecca; Hudson Institute of Medical Research, Melbourne, Australia ; Monash University, Melbourne, Australia
Lim, Sai Kiang; Institute of Medical Biology (IMB), Agency for Science and Technology (ASTAR), Singapore
Linē, Aija; Latvian Biomedical Research and Study Centre, Riga, Latvia
Linnemannstöns, Karen; University Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany ; University Medical Center Göttingen, Hematology and Oncology, Göttingen, Germany
Llorente, Alicia; Oslo University Hospital-The Norwegian Radium Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Oslo, Norway
Lombard, Catherine A; Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
Lorenowicz, Magdalena J; Utrecht University, University Medical Center Utrecht, Center for Molecular Medicine & Regenerative Medicine Center, Utrecht, The Netherlands
Lörincz, Ákos M; Semmelweis University, Department of Physiology, Budapest, Hungary
Lötvall, Jan; University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden
Lovett, Jason; Stellenbosch University, Department of Physiological Sciences, Stellenbosch, South Africa
Lowry, Michelle C; Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Dublin, Ireland
Loyer, Xavier; INSERM UMR-S 970, Paris Cardiovascular Research Center, Paris, France ; Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Lu, Quan; Harvard University, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Lukomska, Barbara; Mossakowski Medical Research Centre, NeuroRepair Department, Warsaw, Poland
Lunavat, Taral R; K.G. Jebsen Brain Tumor Research Centre, Department of Biomedicine, University of Bergen, Bergen, Norway
Maas, Sybren Ln; Utrecht University, University Medical Center Utrecht, Department of Neurosurgery, Brain Center Rudolf Magnus, Institute of Neurosciences, Utrecht, The Netherlands ; Utrecht University, University Medical Center Utrecht, Department of Pathology, Utrecht, The Netherlands
Malhi, Harmeet; Mayo Clinic, Rochester, MN, USA
Marcilla, Antonio; Universitat de València, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Àrea de Parasitologia, Valencia, Spain ; Universitat de València, Health Research Institute La Fe, Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Valencia, Spain
Mariani, Jacopo; Università degli Studi di Milano, Department of Clinical Sciences and Community Health, EPIGET LAB, Milan, Italy
Mariscal, Javier; Cedars-Sinai Medical Center, Los Angeles, CA, USA
Martens-Uzunova, Elena S; Department of Urology, Rotterdam, The Netherlands
Martin-Jaular, Lorena; Institut Curie, INSERM U932, PSL Research University, Paris, France
Martinez, M Carmen; INSERM U1063, Université d'Angers, CHU d'Angers, Angers, France
Martins, Vilma Regina; A.C.Camargo Cancer Center, São Paulo, Brazil
Mathieu, Mathilde; Institut Curie, INSERM U932, PSL Research University, Paris, France
Mathivanan, Suresh; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Maugeri, Marco; University of Gothenburg, Sahlgrenska Academy, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden
McGinnis, Lynda K; University of Southern California, Los Angeles, CA, USA
McVey, Mark J; SickKids Hospital, Department of Anesthesia and Pain Medicine, Toronto, Canada ; University of Toronto, Department of Anesthesia, Toronto, Canada
Meckes, David G; Florida State University College of Medicine, Department of Biomedical Sciences, Tallahassee, FL, USA
Meehan, Katie L; The School of Biomedical Sciences, University of Western Australia, Perth, Australia
Mertens, Inge; University of Antwerp, Centre for Proteomics, Antwerp, Belgium ; Vlaamse Instelling voor Technologisch Onderzoek (VITO), Mol, Belgium
Minciacchi, Valentina R; Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany
Möller, Andreas; QIMR Berghofer Medical Research Institute, Herston, Australia
Møller Jørgensen, Malene; Aalborg University Hospital, Department of Clinical Immunology, Aalborg, Denmark ; EVSEARCH.DK, Denmark
Morales-Kastresana, Aizea; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA
Morhayim, Jess; Erasmus MC, Rotterdam, The Netherlands
Mullier, François; Namur Thrombosis and Hemostasis Center (NTHC), NARILIS, Namur, Belgium ; Université Catholique de Louvain, CHU UCL Namur, Hematology-Hemostasis Laboratory, Yvoir, Belgium
Muraca, Maurizio; University of Padova, Department of Women's and Children's Health, Padova, Italy
Musante, Luca; University of Virginia Health System, Department of Medicine, Division of Nephrology, Charlottesville, VA, USA
Mussack, Veronika; Technical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany
Muth, Dillon C; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA
Myburgh, Kathryn H; Stellenbosch University, Department of Physiological Sciences, Stellenbosch, South Africa
Najrana, Tanbir; Brown University, Women and Infants Hospital, Providence, RI, USA
Nawaz, Muhammad; University of Gothenburg, Sahlgrenska Academy, Department of Rheumatology and Inflammation Research, Gothenburg, Sweden
Nazarenko, Irina; German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany ; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Institute for Infection Prevention and Hospital Epidemiology, Freiburg, Germany
Nejsum, Peter; Aarhus University, Department of Clinical Medicine, Aarhus, Denmark
Neri, Christian; Sorbonne Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging (B2A), Team Compensation in Neurodegenerative and Aging (Brain-C), Paris, France
Neri, Tommaso; University of Pisa, Centro Dipartimentale di Biologia Cellulare Cardio-Respiratoria, Pisa, Italy
Nieuwland, Rienk; Academic Medical Centre of the University of Amsterdam, Department of Clinical Chemistry and Vesicle Observation Centre, Amsterdam, The Netherlands
Nimrichter, Leonardo; Universidade Federal do Rio de Janeiro, Instituto de Microbiologia, Rio de Janeiro, Brazil
Nolan, John P; Scintillon Institute, La Jolla, CA, USA
Nolte-'t Hoen, Esther Nm; Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands
Noren Hooten, Nicole; National Institutes of Health, National Institute on Aging, Baltimore, MD, USA
O'Driscoll, Lorraine; Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Panoz Institute & Trinity Biomedical Sciences Institute, Dublin, Ireland
O'Grady, Tina ; Université de Liège - ULiège > Département des sciences de la vie > Génétique et biologie moléculaires animales
O'Loghlen, Ana; Queen Mary University of London, Blizard Institute, Epigenetics & Cellular Senescence Group, London, UK
Ochiya, Takahiro; National Cancer Center Research Institute, Division of Molecular and Cellular Medicine, Tokyo, Japan
Olivier, Martin; McGill University, The Research Institute of the McGill University Health Centre, Montreal, Canada
Ortiz, Alberto; IIS-Fundacion Jimenez Diaz-UAM, Department of Nephrology and Hypertension, Madrid, Spain ; Spanish Kidney Research Network, REDINREN, Madrid, Spain ; Universidad Autónoma de Madrid, School of Medicine, Department of Medicine, Madrid, Spain
Ortiz, Luis A; Graduate School of Public Health at the University of Pittsburgh, Division of Occupational and Environmental Medicine, Pittsburgh, PA, USA
Osteikoetxea, Xabier; AstraZeneca, Discovery Sciences, IMED Biotech Unit, Cambridge, UK
Østergaard, Ole; Statens Serum Institut, Department of Autoimmunology and Biomarkers, Copenhagen, Denmark ; University of Copenhagen, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark
Ostrowski, Matias; University of Buenos Aires, Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Buenos Aires, Argentina
Park, Jaesung; POSTECH (Pohang University of Science and Technology), Department of Life Sciences, Pohang, South Korea
Pegtel, D Michiel; Amsterdam University Medical Centers, Department of Pathology, Amsterdam, The Netherlands
Peinado, Hector; Spanish National Cancer Research Center (CNIO), Molecular Oncology Programme, Microenvironment and Metastasis Laboratory, Madrid, Spain
Perut, Francesca; IRCCS - Istituto Ortopedico Rizzoli, Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Bologna, Italy
Pfaffl, Michael W; Technical University of Munich, TUM School of Life Sciences Weihenstephan, Division of Animal Physiology and Immunology, Freising, Germany
Phinney, Donald G; The Scripps Research Institute-Scripps Florida, Department of Molecular Medicine, Jupiter, FL, USA
Pieters, Bartijn Ch; Radboud University Medical Center, Department of Rheumatology, Nijmegen, The Netherlands
Pink, Ryan C; Oxford Brookes University, Department of Biological and Medical Sciences, Oxford, UK
Pisetsky, David S; Duke University Medical Center, Departments of Medicine and Immunology, Durham, NC, USA ; Durham VAMC, Medical Research Service, Durham, NC, USA
Pogge von Strandmann, Elke; Philipps University Marburg, Experimental Tumor Biology, Marburg, Germany
Polakovicova, Iva; Pontificia Universidad Católica de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile ; Pontificia Universidad Católica de Chile, Faculty of Medicine, Department of Hematology-Oncology, Santiago, Chile
Poon, Ivan Kh; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Powell, Bonita H; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA
Prada, Ilaria; CNR Institute of Neuroscience, Milan, Italy
Pulliam, Lynn; University of California, San Francisco, CA, USA ; Veterans Affairs Medical Center, San Francisco, CA, USA
Quesenberry, Peter; The Warren Alpert Medical School of Brown University, Department of Medicine, Providence, RI, USA
Radeghieri, Annalisa; CSGI - Research Center for Colloids and Nanoscience, Florence, Italy ; University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy
Raffai, Robert L; Department of Veterans Affairs, San Francisco, CA, USA ; University of California, San Francisco, CA, USA
Raimondo, Stefania; University of Palermo, Department of Biopathology and Medical Biotechnologies, Palermo, Italy
Rak, Janusz; McGill University, Montreal, Canada ; McGill University, The Research Institute of the McGill University Health Centre, Montreal, Canada
Ramirez, Marcel I; Instituto Oswaldo Cruz, Rio de Janeiro, Brazil ; Universidade Federal de Paraná, Paraná, Brazil
Raposo, Graça; Institut Curie, CNRS UMR144, PSL Research University, Paris, France
Rayyan, Morsi S; University of Michigan Medical School, Ann Arbor, MI, USA
Regev-Rudzki, Neta; Weizmann Institute of Science, Department of Biomolecular Sciences, Rehovot, Israel
Ricklefs, Franz L; University Medical Center Hamburg-Eppendorf, Department of Neurosurgery, Hamburg, Germany
Robbins, Paul D; University of Minnesota Medical School, Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, MN, USA
Roberts, David D; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Pathology, Bethesda, MD, USA
Rodrigues, Silvia C; CNC, Coimbra, Portugal ; Exogenus Therapeutics, Cantanhede, Portugal
Rohde, Eva; Paracelsus Medical University, Department of Transfusion Medicine, Salzburg, Austria ; Paracelsus Medical University, GMP Unit, Salzburg, Austria ; Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Salzburg, Austria
Rome, Sophie; University of Lyon, Lyon-Sud Faculty of Medicine, CarMeN Laboratory (UMR INSERM 1060-INRA 1397), Pierre-Bénite, France
Rouschop, Kasper Ma; Maastricht University, GROW, School for Oncology and Developmental Biology, Maastricht Radiation Oncology (MaastRO) Lab, Maastricht, The Netherlands
Rughetti, Aurelia; Sapienza University of Rome, Department of Experimental Medicine, Rome, Italy
Russell, Ashley E; West Virginia University, Morgantown, WV, USA
Saá, Paula; American Red Cross, Scientific Affairs, Gaithersburg, MD, USA
Sahoo, Susmita; Icahn School of Medicine at Mount Sinai, Department of Medicine, Cardiology, New York City, NY, USA
Salas-Huenuleo, Edison; Advanced Center for Chronic Diseases, Santiago, Chile ; University of Chile, Faculty of Chemical and Pharmaceutical Science, Laboratory of Nanobiotechnology and Nanotoxicology, Santiago, Chile
Sánchez, Catherine; Clínica las Condes, Extracellular Vesicles in Personalized Medicine Group, Santiago, Chile
Saugstad, Julie A; Oregon Health & Science University, Department of Anesthesiology & Perioperative Medicine, Portland, OR, USA
Saul, Meike J; Technische Universität Darmstadt, Department of Biology, Darmstadt, Germany
Schiffelers, Raymond M; University Medical Center Utrecht, Laboratory for Clinical Chemistry & Hematology, Utrecht, The Netherlands
Schneider, Raphael; University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Canada ; University of Toronto, Department of Medicine, Division of Neurology, Toronto, Canada
Schøyen, Tine Hiorth; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA
Scott, Aaron; University of Bristol, Bristol, UK
Shahaj, Eriomina; Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Immunotherapy of Human Tumors, Milan, Italy
Sharma, Shivani; University of California, Los Angeles, California NanoSystems Institute, Los Angeles, CA, USA ; University of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA ; University of California, Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA
Shatnyeva, Olga; AstraZeneca, Discovery Sciences, IMED Biotech Unit, Gothenburg, Sweden
Shekari, Faezeh; Royan Institute for Stem Cell Biology and Technology, ACECR, Cell Science Research Center, Department of Stem Cells and Developmental Biology, Tehran, Iran
Shelke, Ganesh Vilas; University of Gothenburg, Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Cancer Center, Gothenburg, Sweden ; University of Gothenburg, Institute of Medicine at Sahlgrenska Academy, Krefting Research Centre, Gothenburg, Sweden
Shetty, Ashok K; Research Service, Olin E. Teague Veterans' Medical Center, Temple, TX, USA ; Texas A&M University College of Medicine, Institute for Regenerative Medicine and Department of Molecular and Cellular Medicine, College Station, TX, USA
Shiba, Kiyotaka; Cancer Institute of JFCR, Tokyo, Japan
Siljander, Pia R-M; University of Helsinki, EV Core Facility, Helsinki, Finland ; University of Helsinki, Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, EV group, Helsinki, Finland
Silva, Andreia M; INEB - Instituto de Engenharia Biomédica, Porto, Portugal ; University of Porto, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal ; University of Porto, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal
Skowronek, Agata; Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland
Snyder, Orman L; Kansas State University, College of Veterinary Medicine, Manhattan, KS, USA
Soares, Rodrigo Pedro; René Rachou Institute/FIOCRUZ, Belo Horizonte, Brazil
Sódar, Barbara W; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Soekmadji, Carolina; QIMR Berghofer Medical Research Institute, Herston, Australia ; The University of Queensland, Brisbane, Australia
Sotillo, Javier; James Cook University, Australian Institute of Tropical Health and Medicine, Centre for Biodiscovery and Molecular Development of Therapeutics, Cairns, Australia
Stahl, Philip D; Washington University, Saint Louis, MO, USA
Stoorvogel, Willem; Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands
Stott, Shannon L; Harvard Medical School, Department of Medicine, Boston, MA, USA ; Massachusetts General Cancer Center, Boston, MA, USA
Swift, Simon; University of Auckland, Department of Molecular Medicine and Pathology, Auckland, New Zealand
Tahara, Hidetoshi; Hiroshima University, Institute of Biomedical & Health Sciences, Department of Cellular and Molecular Biology, Hiroshima, Japan
Tewari, Muneesh; University of Michigan, Biointerfaces Institute, Ann Arbor, MI, USA ; University of Michigan, Department of Biomedical Engineering, Ann Arbor, MI, USA ; University of Michigan, Department of Internal Medicine - Hematology/Oncology Division, Ann Arbor, MI, USA
Timms, Kate; University of Manchester, Manchester, UK
Tiwari, Swasti; Georgetown University, Department of Medicine, Washington, DC, USA ; Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Molecular Medicine & Biotechnology, Lucknow, India
Tixeira, Rochelle; La Trobe University, La Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, Bundoora, Australia
Tkach, Mercedes; Institut Curie, INSERM U932, PSL Research University, Paris, France
Toh, Wei Seong; National University of Singapore, Faculty of Dentistry, Singapore
Torrecilhas, Ana Claudia; UNIFESP, Departamento de Ciências Farmacêuticas, Diadema, Brazil
Tosar, Juan Pablo; Institut Pasteur de Montevideo, Functional Genomics Unit, Montevideo, Uruguay ; Universidad de la República, Faculty of Science, Nuclear Research Center, Analytical Biochemistry Unit, Montevideo, Uruguay
Toxavidis, Vasilis; Beth Israel Deaconess Medical Center, Boston, MA, USA
Urbanelli, Lorena; University of Perugia, Department of Chemistry, Biology and Biotechnology, Perugia, Italy
Vader, Pieter; University Medical Center Utrecht, Laboratory for Clinical Chemistry & Hematology, Utrecht, The Netherlands
van Balkom, Bas Wm; University Medical Center Utrecht, Department of Nephrology and Hypertension, Utrecht, The Netherlands
van der Grein, Susanne G; Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands
Van Deun, Jan; Cancer Research Institute Ghent, Ghent, Belgium ; Ghent University, Department of Radiation Oncology and Experimental Cancer Research, Laboratory of Experimental Cancer Research, Ghent, Belgium
van Herwijnen, Martijn Jc; Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands
Van Keuren-Jensen, Kendall; TGen, Neurogenomics Division, Phoenix, AZ, USA
van Niel, Guillaume; Center for Psychiatry and Neuroscience, INSERM U894, Paris, France
van Royen, Martin E; Department of Pathology, Erasmus MC, Erasmus Optical Imaging Centre, Rotterdam, The Netherlands
van Wijnen, Andre J; Mayo Clinic, Department of Orthopedic Surgery, Rochester, MN, USA
Vasconcelos, M Helena; IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal ; University of Porto, Faculty of Pharmacy (FFUP), Porto, Portugal ; University of Porto, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Vechetti, Ivan J; University of Kentucky, College of Medicine, Department of Physiology, Lexington, KY, USA
Veit, Tiago D; Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Microbiologia, Imunologia e Parasitologia, Porto Alegre, Brazil
Vella, Laura J; The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia ; The University of Melbourne, The Department of Medicine, Melbourne, Australia
Velot, Émilie; UMR 7365 CNRS-Université de Lorraine, Vandœuvre-lès-Nancy, France
Verweij, Frederik J; Center for Psychiatry and Neuroscience, INSERM U894, Paris, France
Vestad, Beate; Oslo University Hospital Rikshospitalet, Research Institute of Internal Medicine, Oslo, Norway ; Regional Research Network on Extracellular Vesicles, RRNEV, Oslo, Norway ; University of Oslo, Institute of Clinical Medicine, Oslo, Norway
Viñas, Jose L; Kidney Research Centre, Ottawa, Canada ; Ottawa Hospital Research Institute, Ottawa, Canada ; University of Ottawa, Ottawa, Canada
Visnovitz, Tamás; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Vukman, Krisztina V; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Wahlgren, Jessica; University of Gothenburg, The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Mölndal, Sweden
Watson, Dionysios C; Case Western Reserve University, Department of Medicine, Cleveland, OH, USA ; University Hospitals Cleveland Medical Center, Department of Medicine, Cleveland, OH, USA
Wauben, Marca Hm; Utrecht University, Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht, The Netherlands
Weaver, Alissa; Vanderbilt University School of Medicine, Department of Cell and Developmental Biology, Nashville, TN, USA
Webber, Jason P; Cardiff University, School of Medicine, Cardiff, UK
Weber, Viktoria; Danube University Krems, Department for Biomedical Research and Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis, Krems an der Donau, Austria
Wehman, Ann M; University of Würzburg, Rudolf Virchow Center, Würzburg, Germany
Weiss, Daniel J; The University of Vermont Medical Center, Department of Medicine, Burlington, VT, USA
Welsh, Joshua A; National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD, USA
Wendt, Sebastian; University Hospital RWTH Aachen, Department of Thoracic and Cardiovascular Surgery, Aachen, Germany
Wheelock, Asa M; Karolinska Institute, Department of Medicine and Center for Molecular Medicine, Respiratory Medicine Unit, Stockholm, Sweden
Wiener, Zoltán; Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary
Witte, Leonie; University Medical Center Göttingen, Developmental Biochemistry, Göttingen, Germany ; University Medical Center Göttingen, Hematology and Oncology, Göttingen, Germany
Wolfram, Joy; Chinese Academy of Sciences, Wenzhou Institute of Biomaterials and Engineering, Wenzhou, China ; Houston Methodist Research Institute, Department of Nanomedicine, Houston, TX, USA ; Mayo Clinic, Department of Transplantation Medicine/Department of Physiology and Biomedical Engineering, Jacksonville, FL, USA
Xagorari, Angeliki; George Papanicolaou Hospital, Public Cord Blood Bank, Department of Haematology - BMT Unit, Thessaloniki, Greece
Xander, Patricia; Universidade Federal de São Paulo Campus Diadema, Departamento de Ciências Farmacêuticas, Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, São Paulo, Brazil
Xu, Jing; BC Cancer, Canada's Michael Smith Genome Sciences Centre, Vancouver, Canada ; Simon Fraser University, Department of Molecular Biology and Biochemistry, Burnaby, Canada
Yan, Xiaomei; Xiamen University, Department of Chemical Biology, Xiamen, China
Yáñez-Mó, María; Centro de Biología Molecular Severo Ochoa, Instituto de Investigación Sanitaria la Princesa (IIS-IP), Madrid, Spain ; Universidad Autónoma de Madrid, Departamento de Biología Molecular, Madrid, Spain
Yin, Hang; Tsinghua University, School of Pharmaceutical Sciences, Beijing, China
Yuana, Yuana; Technical University Eindhoven, Faculty Biomedical Technology, Eindhoven, The Netherlands
Zappulli, Valentina; University of Padova, Department of Comparative Biomedicine and Food Science, Padova, Italy
Zarubova, Jana; Institute of Physiology CAS, Department of Biomaterials and Tissue Engineering, BIOCEV, Vestec, Czech Republic ; Institute of Physiology CAS, Department of Biomaterials and Tissue Engineering, Prague, Czech Republic ; University of California, Los Angeles, Department of Bioengineering, Los Angeles, CA, USA
Žėkas, Vytautas; Vilnius University, Institute of Biomedical Sciences, Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Vilnius, Lithuania
Zhang, Jian-Ye; Guangzhou Medical University, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Key Laboratory of Molecular Target & Clinical Pharmacology, Guangzhou, China
Zhao, Zezhou; The Johns Hopkins University School of Medicine, Department of Molecular and Comparative Pathobiology, Baltimore, MD, USA
Zheng, Lei; Nanfang Hospital, Southern Medical University, Department of Clinical Laboratory Medicine, Guangzhou, China
Zheutlin, Alexander R; University of Michigan Medical School, Ann Arbor, MI, USA
Zickler, Antje M; Karolinska Institute, Clinical Research Center, Unit for Molecular Cell and Gene Therapy Science, Stockholm, Sweden
Zimmermann, Pascale; Aix-Marseille Université, Institut Paoli-Calmettes, INSERM U1068, CNRS UMR7258, Centre de Recherche en Cancérologie de Marseille, Marseille, France ; KU Leuven (Leuven University), Department of Human Genetics, Leuven, Belgium
Zivkovic, Angela M; University of California, Davis, Department of Nutrition, Davis, CA, USA
Zocco, Davide; Exosomics Siena SpA, Siena, Italy
Zuba-Surma, Ewa K; Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
ANR - Agence Nationale de la Recherche NIA - National Institute on Aging NIDA - National Institute on Drug Abuse INSERM - Institut National de la Santé et de la Recherche Médicale INCa - Institut National du Cancer Fondation ARC pour la Recherche sur le Cancer Sidaction Institut Curie
Funding text :
CT’s laboratory is funded by INSERM, Institut Curie, Ministry of Education, and grants from INCa (INCA-11548), French National Research Agency (ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043), SIDACTION (17-1-AAE-1138), Fondation ARC (PGA1 RF20180206962, PJA 20171206453). KWW and CT receive support from NIDA (DA040385). KWW is also supported in part by NIA AG057430, NIDA DA047807 and NIMH MH118164. The authors are grateful to all respondents to the various surveys that supported the MISEV2018 effort, including those who only partially completed the surveys or completed the surveys but declined authorship. They also thank all community members who offered feedback.Funding is listed only for the corresponding authors. CT’s laboratory is funded by INSERM, Institut Curie, Ministry of Education, and grants from INCa (INCA-11548), French National Research Agency (ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043), SIDACTION (17-1-AAE-1138), Fondation ARC (PGA1 RF20180206962, PJA 20171206453). KWW and CT receive support from NIDA (DA040385). KWW is also supported in part by NIA AG057430, NIDA DA047807 and NIMH MH118164.
References, especially those provided to illustrate methods and approaches, are representative only, and are not meant to be a comprehensive review of the literature. Most references were derived from suggestions provided in the MISEV2018 Survey results. Each reference was checked by multiple authors. Citation implies deemed relevance of scientific content and not an endorsement by the authors or ISEV of any particular journal or editorial practice
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