Article (Scientific journals)
Very delayed sinus arrest during complete remission of diffuse large B-cell lymphoma invading right atrium.
Tsugu, Toshimitsu; Nagatomo, Yuji; Matsuyama, Emiko et al.
2021In Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 49 (5), p. 414-418
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Keywords :
R-CHOP protocol; 0Z5B2CJX4D (Fluorodeoxyglucose F18); 4F4X42SYQ6 (Rituximab); 5J49Q6B70F (Vincristine); 80168379AG (Doxorubicin); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone); Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Bradycardia/etiology; Cyclophosphamide/therapeutic use; Doxorubicin/therapeutic use; Electrocardiography; Female; Fluorodeoxyglucose F18; Heart Atria/diagnostic imaging/pathology; Heart Neoplasms/complications/diagnostic imaging/pathology/therapy; Humans; Lymphoma, Large B-Cell, Diffuse/complications/diagnostic imaging/pathology/therapy; Middle Aged; Neoplasm Invasiveness; Positron Emission Tomography Computed Tomography; Prednisone/therapeutic use; Remission Induction; Rituximab/therapeutic use; Sinus Arrest, Cardiac/etiology; Uterine Neoplasms/complications/diagnostic imaging/therapy; Vincristine/therapeutic use
Abstract :
[en] Diffuse large B-cell lymphoma (DLBCL)-associated arrhythmias may be due to cardiac involvement or may be chemotherapy-induced. There have been no reports of significant arrhythmias with normal cardiac function occurring during the complete remission of DLBCL. A 57-year-old female, who had had no history of abnormal electrocardiograms (ECGs) in annual medical checkups, was admitted to our hospital because of low-grade fever, night sweats, and weight loss. On admission, ECG revealed a variable rhythm consisting of sinus beats and occasional escape beats. Computed tomography and 18F-fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) revealed two masses in the right atrium (RA) and the uterus. Total hysterectomy was performed, and pathological findings were consistent with diffuse large B-cell lymphoma (DLBCL). Chemotherapy (R-CHOP) was initiated. After two chemotherapy cycles, RA tumors disappeared, and bradyarrhythmia simultaneously converted to sinus rhythm without antiarrhythmic drug therapy. Six months after completion of chemotherapy, FDG-PET/CT revealed negative uptake in the RA and the uterus. The patient attained complete remission of DLBCL, but ECG showed bradycardia because of sinus arrest. Our case suggests that DLBCL-induced arrhythmia can occur even after its remission and should be monitored.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Tsugu, Toshimitsu;  Department of Cardiology, Heart Valve Clinic, University of Liège Hospital, GIGA
Nagatomo, Yuji;  Department of Cardiology, National Defense Medical College Hospital, Tokorozawa,
Matsuyama, Emiko;  Department of Cardiology, Federation of National Public Service Personnel Mutual
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Mitamura, Hideo;  Department of Cardiology, Federation of National Public Service Personnel Mutual
Language :
English
Title :
Very delayed sinus arrest during complete remission of diffuse large B-cell lymphoma invading right atrium.
Publication date :
July 2021
Journal title :
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
eISSN :
1308-4488
Volume :
49
Issue :
5
Pages :
414-418
Peer reviewed :
Peer reviewed
Available on ORBi :
since 18 May 2022

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