Article (Scientific journals)
Cancer and Infective Endocarditis: Characteristics and Prognostic Impact.
Cosyns, Bernard; Roosens, Bram; LANCELLOTTI, Patrizio et al.
2021In Frontiers in Cardiovascular Medicine, 8, p. 766996
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Keywords :
cancer; cardiac surgery; infective endocarditis; registry; valve disease
Abstract :
[en] Background: The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry. Methods: Three thousand and eighty-five patients with IE were identified based on the ESC 2015 criteria. Three hundred and fifty-nine (11.6%) IE cancer patients were compared to 2,726 (88.4%) cancer-free IE patients. Results: In cancer patients, IE was mostly community-acquired (74.8%). The most frequently identified microorganisms were S. aureus (25.4%) and Enterococci (23.8%). The most frequent complications were acute renal failure (25.9%), embolic events (21.7%) and congestive heart failure (18.1%). Theoretical indication for cardiac surgery was not significantly different between groups (65.5 vs. 69.8%, P = 0.091), but was effectively less performed when indicated in IE patients with cancer (65.5 vs. 75.0%, P = 0.002). Compared to cancer-free IE patients, in-hospital and 1-year mortality occurred in 23.4 vs. 16.1%, P = 0.006, and 18.0 vs. 10.2%; P < 0.001, respectively. In IE cancer patients, predictors of mortality by multivariate analysis were creatinine > 2 mg/dL, congestive heart failure and unperformed cardiac surgery (when indicated). Conclusions: Cancer in IE patients is common and associated with a worse outcome. This large, observational cohort provides new insights concerning the contemporary profile, management, and clinical outcomes of IE cancer patients across a wide range of countries.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Cosyns, Bernard;  Centrum Voor Hart- en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB),  ; In vivo Cellular and Molecular Imaging (ICMI) Center, Vrije Universiteit Brussel
Roosens, Bram;  Centrum Voor Hart- en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB),
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Laroche, Cécile;  EURObservational Research Programme, European Society of Cardiology, Antibes,
Dulgheru, Raluca;  Cardiology Department, University Hospital Centre, Centre Hospitalier
Scheggi, Valentina;  Cardiothoracic and Vascular Department, Careggi University Hospital, Florence,
Vilacosta, Isidre;  Department of Cardiology, Hospital Clínico San Carlos, Universidad Complutense de
Pasquet, Agnès;  Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et  ; Divisions of Cardiology and Cardiothoracic Surgery, Cliniques Universitaires
Piper, Cornelia;  Clinic for General and Interventional Cardiology/Angiology, Herz- und
Reyes, Graciela;  Echo Lab Department, Hospital de Alta Complejidad en red El Cruce, Florencio
Mahfouz, Essam;  Mansoura Specialized Medical Hospital, Mansoura University, Mansoura, Egypt.
Kobalava, Zhanna;  Department of Cardiology, Rossiyskiy Universitet Druzhby Narodov (RUDN)
Piroth, Lionel;  Infectious Diseases Department, University Hospital, INSERM CIC1432, University
Kasprzak, Jarosław D;  Bieganski Hospital, Medical University of Lodz, Łódź, Poland.
Moreo, Antonella;  A. De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan,
Faucher, Jean-François;  CHU Limoges, Department of Infectious Diseases and Tropical Medicine, Limoges
Ternacle, Julien;  Cardiology Department, Henri Mondor Hospital, SOS Endocardites, DHU ATVB, INSERM  ; Fellow Equipe, Team du Dr Philippe Pibarot, Institut Universitaire de Cardiologie
Meshaal, Marwa;  Cardiology Department, Kasr Al Ainy, Cairo University, Cairo, Egypt.
Maggioni, Aldo P;  EURObservational Research Programme, European Society of Cardiology, Antibes,  ; Maria Cecilia Hospital, Gruppo Villa Maria (GVM) Care & Research, Cotignola,
Iung, Bernard;  Bichat Hospital, APHP, DHU Fire, Paris Diderot University, Paris, France.
Habib, Gilbert;  AP-HM, La Timone Hospital, Cardiology Department, Marseille, France. ; Aix Marseille University, IRD, AP-HM, MEPHI, IHU-Mediterranean Infection,
More authors (11 more) Less
Language :
English
Title :
Cancer and Infective Endocarditis: Characteristics and Prognostic Impact.
Publication date :
2021
Journal title :
Frontiers in Cardiovascular Medicine
eISSN :
2297-055X
Publisher :
Frontiers Research Foundation, Lausanne, Ch
Volume :
8
Pages :
766996
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021 Cosyns, Roosens, Lancellotti, Laroche, Dulgheru, Scheggi, Vilacosta, Pasquet, Piper, Reyes, Mahfouz, Kobalava, Piroth, Kasprzak, Moreo, Faucher, Ternacle, Meshaal, Maggioni, Iung and Habib.
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