oncology; radiation therapy; cancer chemotherapy; neoadjuvant chemotherapy; head and neck cancer; logistic discriminant analysis; treatment choice; oncologie; radiothérapie oncologie; chimiothérapie anti-cancéreuse; chimiothérapie néoadjuvante; cancers de la tête et du cou; analyse logistique discriminante; choix du traitement; prediction of chemotherapy response; prédiction de la réponse à la chimiothérapie
Abstract :
[en] A low dose neoadjuvant chemotherapy was given to 258 consecutive head and neck cancer patients. A 3/4 tumour reduction appeared to be critical to obtain subsequently a maximum result by radiotherapy. Through logistic discriminant analysis an algorithm gave the probability of chemotherapy response for each individual clinical situation. Tested prospectively in 97 further patients, the model was fully validated. Choice of the better appropriate treatment e.g. radical surgery versus exclusive radiotherapy is possible at the very time of staging.
Disciplines :
Oncology
Author, co-author :
Deneufbourg, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Radiothérapie
Language :
English
Title :
Prediction of response of Head and Neck Cancers to Neoadjuvant Chemotherapy
Publication date :
26 July 1992
Event name :
3rd International Conference on Head and Neck Cancer
Event organizer :
American Society for Head and Neck Surgery Society of Head and Neck Surgeons
