Article (Scientific journals)
Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins.
Daix, Virginie; Schroeder, Hélène; Praet, N. et al.
2007In Insect Molecular Biology, 16 (2), p. 155-66
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Keywords :
Amino Acid Sequence; Animals; Complement Inactivator Proteins/chemistry/genetics/metabolism; Evolution; Female; Immunohistochemistry; Ixodes/chemistry/genetics/metabolism; Molecular Sequence Data; Multigene Family; Salivary Glands/metabolism; Salivary Proteins and Peptides/chemistry; Sequence Homology, Amino Acid
Abstract :
[en] The alternative pathway of complement is an important innate defence against pathogens including ticks. This component of the immune system has selected for pathogens that have evolved countermeasures. Recently, a salivary protein able to inhibit the alternative pathway was cloned from the American tick Ixodes scapularis (Valenzuela et al., 2000; J. Biol. Chem. 275, 18717-18723). Here, we isolated two different sequences, similar to Isac, from the transcriptome of I. ricinus salivary glands. Expression of these sequences revealed that they both encode secreted proteins able to inhibit the complement alternative pathway. These proteins, called I. ricinus anticomplement (IRAC) protein I and II, are coexpressed constitutively in I. ricinus salivary glands and are upregulated during blood feeding. Also, we demonstrated that they are the products of different genes and not of alleles of the same locus. Finally, phylogenetic analyses demonstrate that ticks belonging to the Ixodes ricinus complex encode a family of relatively small anticomplement molecules undergoing diversification by positive Darwinian selection.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Daix, Virginie ;  Université de Liège - ULiège > Immunologie et vaccinologie
Schroeder, Hélène ;  Université de Liège - ULiège > Immunologie et vaccinologie
Praet, N.;  Université de Liège - ULiège > Immunologie et vaccinologie
Georgin, J.-P.;  Université de Liège - ULiège > Immunologie et vaccinologie
Chiappino, I.;  Université de Liège - ULiège > Immunologie et vaccinologie
Gillet, Laurent  ;  Université de Liège - ULiège > Immunologie et vaccinologie
de Fays, K.;  Université de Liège - ULiège > Immunologie et vaccinologie
Decrem, Y.
Leboulle, G.
Godfroid, E.
Bollen, A.
Gern, L.
Sharp, P. M.
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie et vaccinologie
More authors (5 more) Less
Language :
English
Title :
Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins.
Publication date :
2007
Journal title :
Insect Molecular Biology
ISSN :
0962-1075
eISSN :
1365-2583
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
16
Issue :
2
Pages :
155-66
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 November 2009

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