Article (Scientific journals)
Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.
Michiels, Carine; Minet, Emmanuel; Mottet, Denis et al.
2002In Free Radical Biology and Medicine, 33 (9), p. 1231-42
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Keywords :
Animals; Anoxia/genetics/metabolism; DNA-Binding Proteins/genetics/metabolism; Gene Expression Regulation/drug effects; Humans; Hyperoxia/genetics/metabolism; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; NF-kappa B/genetics/metabolism; Nuclear Proteins/genetics/metabolism; Oxygen/pharmacology; Reactive Oxygen Species/metabolism/pharmacology; Transcription Factors
Abstract :
[en] Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive oxygen species (ROS), while a decrease in oxygen concentration impairs energy availability and, hence, cell viability. Cells have developed strategies to respond to changes in oxygen tension: specific systems detect excessive ROS and hypoxia, leading to the activation of specific transcription factors and expression of appropriate target genes. The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels. Some of the physiological responses initiated by these transcription factors are also mentioned.
Disciplines :
Biochemistry, biophysics & molecular biology
Oncology
Author, co-author :
Michiels, Carine
Minet, Emmanuel
Mottet, Denis ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases
Raes, Martine
Language :
English
Title :
Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.
Publication date :
2002
Journal title :
Free Radical Biology and Medicine
ISSN :
0891-5849
eISSN :
1873-4596
Publisher :
Elsevier Science, Tarrytown, United States - New York
Volume :
33
Issue :
9
Pages :
1231-42
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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