Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.

Animals; Anoxia/genetics/metabolism; DNA-Binding Proteins/genetics/metabolism; Gene Expression Regulation/drug effects; Humans; Hyperoxia/genetics/metabolism; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; NF-kappa B/genetics/metabolism; Nuclear Proteins/genetics/metabolism; Oxygen/pharmacology; Reactive Oxygen Species/metabolism/pharmacology; Transcription Factors

Abstract :

[en] Aerobic life is dependent on molecular oxygen for ATP regeneration, but only possible in a narrow range of oxygen concentrations. Increased oxygen tension is toxic through the generation of reactive oxygen species (ROS), while a decrease in oxygen concentration impairs energy availability and, hence, cell viability. Cells have developed strategies to respond to changes in oxygen tension: specific systems detect excessive ROS and hypoxia, leading to the activation of specific transcription factors and expression of appropriate target genes. The aim of this review is to describe how hypoxia-inducible factor-1 (HIF-1) and nuclear factor-kappaB (NF-kappaB) are regulated and what could be the sensors to the changes in oxygen levels. Some of the physiological responses initiated by these transcription factors are also mentioned.

Disciplines :

Biochemistry, biophysics & molecular biology
Oncology

Author, co-author :

Michiels, Carine

Minet, Emmanuel

Mottet, Denis ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases

Raes, Martine

Language :

English

Title :

Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes.

Publication date :

2002

Journal title :

Free Radical Biology and Medicine

ISSN :

0891-5849

eISSN :

1873-4596

Publisher :

Elsevier Science, Tarrytown, United States - New York

Volume :

Issue :

Pages :

1231-42

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture

Available on ORBi :

since 24 November 2009

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