Reference : Many transcription factors interact synergistically with steroid receptors.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/29026
Many transcription factors interact synergistically with steroid receptors.
English
Schule, Roland [> > > >]
Muller, Marc mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Kaltschmidt, Christian [> > > >]
Renkawitz, Rainer [> > > >]
1988
Science
American Association for the Advancement of Science
242
4884
1418-20
Yes (verified by ORBi)
International
0036-8075
Washington
DC
[en] Base Sequence ; Binding Sites ; Cloning, Molecular ; Genes ; Hela Cells/metabolism ; Humans ; Molecular Sequence Data ; Plasmids ; Receptors, Glucocorticoid/genetics/metabolism ; Receptors, Progesterone/genetics/metabolism ; Transcription Factors/genetics/metabolism ; Transfection
[en] Progesterone (PRE) or glucocorticoid receptor (GRE) DNA binding sites are often found clustered with binding sites for other transcription factors. Individual protein binding sites were tested without the influence of adjacent factors by analyzing isolated combinations of several transcription factor binding sites with PREs or GREs. All show strong synergistic effects on steroid induction. The degree of synergism is inversely related to the strength of the GRE. Thus, a steroid responsive unit can be composed of several modules that, if positioned correctly, act synergistically.
http://hdl.handle.net/2268/29026
10.1126/science.3201230

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