[fr] After validation of ACKR3 staining by using U87-ACKR3 cell line, we showed that ACKR3 expression was very low in patients GBM stem-like cells. However we detect the receptor on GBM patient tissue, where it appears distributed in various cell subtypes. Both public transcriptomic datasets of GBM and results that we have obtained have revealed that ACKR3 is expressed in tumor cells in situ, but also in cells from the surrounding tumor microenvironment. Morever, ACKR3 expression pattern varies in different regions of a tumor, and between different patients. The role of ACKR3 in GBM growth might be more subtle than expected, and likely involves malignant GBM cells as well as their microenvironment. The role of CXCR4 together with ACKR3 also deserves deep investigation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Isci, Damla ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Veiga, Da; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Belgium
Cokaiko, Julie ; Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, Belgium
LOMBARD, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurochirurgie
Chevigné, Andy ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, Luxembourg
ROGISTER, Bernard ; Université de Liège - ULiège > Département des sciences précliniques BP > Physiologie humaine et physiopathologie
Neirinckx, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Language :
English
Title :
Study of the ACKR3/CXCR7 receptor in glioblastoma
Alternative titles :
[fr] L'étude du récepteur ACKR3/CXCR7 dans le glioblastome
