Article (Scientific journals)
Current Status and Perspectives of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia.
SERVAIS, Sophie; BEGUIN, Yves; BARON, Frédéric
2022In Stem Cells Translational Medicine, 11 (5), p. 461-477
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Keywords :
GVHD prophylaxis; acute myelogenous leukemia; comorbidity index; conditioning regimen; donor selection; elderly patients; geriatric assessment; hematopoietic stem cell transplantation; new drugs
Abstract :
[en] As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular, whether or not to proceed to alloHSCT) for elderly patients with AML remains a difficult decision for the hematologist, since potential toxicity of conditioning regimens, risks of graft-versus-host disease, impaired immune reconstitution and the need for prolonged immunosuppression may be of major concern in these vulnerable patients with complex needs. Hopefully, significant progress has been made over the past decade in alloHSCT for elderly patients and current evidence suggests that chronological age per se (between 60 and 75) is not a reliable predictor of outcome after alloHSCT. Here, we review the current state of alloHSCT in elderly patients with AML and also discuss the different approaches currently being investigated to improve both accessibility to as well as success of alloHSCT in these patients.
Disciplines :
Hematology
Author, co-author :
SERVAIS, Sophie  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
BEGUIN, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
BARON, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Language :
English
Title :
Current Status and Perspectives of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia.
Publication date :
27 May 2022
Journal title :
Stem Cells Translational Medicine
ISSN :
2157-6564
eISSN :
2157-6580
Publisher :
Wiley-Blackwell, Gb
Volume :
11
Issue :
5
Pages :
461-477
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 April 2022

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