Une révolution thérapeutique en rhumatologie : oui, mais….

Biological therapies; Monoclonal antibodies; Rheumatology; Drug clinical research; Tumor Necrosis Factor-alpha; Humans; Arthritis, Psoriatic; Arthritis, Rheumatoid; Polymyalgia Rheumatica; Rheumatology/trends; Medicine (all)

Abstract :

[en] The development of new drugs is a significant activity in a university hospital that favors access to therapeutic novelties to patients. Rheumatology, whose drug armamentarium was poor in the 1980s, has benefited from the huge progresses of immunology in the 1980-1990s, allowing a therapeutic revolution in whom the academic hospital of Liège (CHU Liège) has been strongly implicated. First protocols with anti-TNF-? monoclonal antibodies have been applied in 1997. Sixty-one protocols have been initiated in rheumatoid arthritis, 12 in ankylosing spondylitis, 10 in psoriatic arthritis, 9 in systemic erythematosus lupus, 3 in giant cell arteritis, 1 in polymyalgia rheumatica, 5 in osteoarthritis and 4 in osteoporosis. Potential and pitfalls will be discussed disease by disease and also by drug categories. The balance remains globally positive, but remission is far from be reached.
[fr] La recherche clinique médicamenteuse est une activité importante dans un hôpital universitaire. Elle valide des nouveautés thérapeutiques et fait bénéficier les patients de traitements novateurs bien avant leur mise sur le marché. La rhumatologie est une discipline dont l’arsenal thérapeutique était pauvre dans les années 1980, et les immenses progrès de l’immunologie, réalisés entre 1980 et 1995, lui ont permis de vivre une véritable révolution thérapeutique à laquelle notre service a amplement participé. C’est en 1997 que les premiers traitements par anticorps monoclonaux anti-TNF-? (les traitements dits biologiques) ont été utilisés au CHU de Liège. Soixante et une études seront initiées dans la polyarthrite rhumatoïde, 12 dans la spondylarthrite ankylosante, 10 dans la polyarthrite psoriasique, 9 dans le lupus érythémateux disséminé, 3 dans l’artérite temporale de Horton, une dans la pseudopolyarthrite rhizomélique, une dans la sclérodermie, 5 dans l’arthrose, 4 dans l’ostéoporose. Les espoirs et les déceptions observées dans les différentes indications, et avec les différentes molécules, sont analysées. Le bilan est globalement positif, mais les résultats encore insuffisants que pour arriver au concept de rémission.

Disciplines :

Rheumatology

Author, co-author :

MALAISE, Michel ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie

CHAPELIER, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive

DEWAEL, Thibaut ; Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants

LEONORI, Lorenzo ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie

LEROY, Mathieu ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie

Mailleux, E; ) Service de Rhumatologie, CHU Liège, Belgique

André, Béatrice ; Centre Hospitalier Universitaire de Liège - CHU

Halleux, Sandrine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie

KAISER, Marie-Joëlle ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie

MALAISE, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie

More authors (4 more)

Language :

French

Title :

Une révolution thérapeutique en rhumatologie : oui, mais….

Alternative titles :

[en] Remarkable medical advances in rheumatology : may be….

Publication date :

May 2020

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Revue Medicale de Liege, Belgium

Volume :

Issue :

5-6

Pages :

369-375

Peer reviewed :

Editorial Reviewed verified by ORBi

Available on ORBi :

since 22 April 2022

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